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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2008-1(95)-56-59</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-1075</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОТЕХНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOTECHNOLOGY</subject></subj-group></article-categories><title-group><article-title>Конструирование штамма Vibrio cholerae биовара эльтор гиперпродуцента холерного токсина II типа и определение оптимальных условий для продукции этого белка</article-title><trans-title-group xml:lang="en"><trans-title>Construction of an El Tor Biovariant Vibrio cholerae Strain Capable of Type II Cholera Toxin Hyperproduction and Determining the Optimal Conditions for the Production of This Protein</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горяев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Goryaev</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щелканова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchelkanova</surname><given-names>E. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лозовский</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lozovsky</surname><given-names>Yu. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тучков</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Touchkov</surname><given-names>I. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>N. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский научно-исследовательский противочумный институт «Микроб», Саратов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Anti-Plague Research Institute "Microbe ”, Saratov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2008</year></pub-date><volume>0</volume><issue>1(95)</issue><fpage>56</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Горяев А.А., Щелканова Е.Ю., Лозовский Ю.В., Тучков И.В., Смирнова Н.И., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Горяев А.А., Щелканова Е.Ю., Лозовский Ю.В., Тучков И.В., Смирнова Н.И.</copyright-holder><copyright-holder xml:lang="en">Goryaev A.A., Shchelkanova E.Y., Lozovsky Y.V., Touchkov I.V., Smirnova N.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/1075">https://journal.microbe.ru/jour/article/view/1075</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>холерный вибрион</kwd><kwd>штамм-продуцент холерного токсина</kwd><kwd>реорганизация генома профага СТХφ</kwd><kwd>транспозон Tn5-Mob</kwd></kwd-group><kwd-group xml:lang="en"><kwd>the cholera agent</kwd><kwd>a cholera toxin hyperproducing strain</kwd><kwd>prophage CTXφ genome reorganization</kwd><kwd>Tn5-Mob transposon</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">гранты РФФИ № 06-04­-48310 и РФФИ ОФИ № 06-04-08122</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Журавлева Е.А., Смирнова Н.И.//Мол. генет. - 1991. - №5. - С. 15-19.</mixed-citation><mixed-citation xml:lang="en">Журавлева Е.А., Смирнова Н.И.//Мол. генет. - 1991. - №5. - С. 15-19.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Осин А.В., Нефедов К.С.,Ерошенко Г.А., Смирнова Н.И.//Генетика. - 2005. - Т. 41, №1. - С. 1-10.</mixed-citation><mixed-citation xml:lang="en">Осин А.В., Нефедов К.С.,Ерошенко Г.А., Смирнова Н.И.//Генетика. - 2005. - Т. 41, №1. - С. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шагинян Б.М., Маракуша Б.И.//Журн. микробиол. - 1983. - №7. - С. 92-96.</mixed-citation><mixed-citation xml:lang="en">Шагинян Б.М., Маракуша Б.И.//Журн. микробиол. - 1983. - №7. - С. 92-96.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Difeita V.J., Neely М., Taylor R.K., Bruss P.//Proc. 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