<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2020-3-36-42</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-1361</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эпидемический потенциал COVID-19 в Омской области на фоне противоэпидемических мероприятий</article-title><trans-title-group xml:lang="en"><trans-title>Epidemic Potential of COVID-19 in Omsk Region during Anti-Epidemic Measures</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0756-2271</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блох</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Blokh</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644080, Омск, Проспект Мира, 7</p><p>Российская Федерация, 644099, Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>7, Prospect Mira, Omsk, 644080, Russian Federation</p><p>12, Lenin St., Omsk, 644099, Russian Federation</p></bio><email xlink:type="simple">mail@oniipi.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7220-4366</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пеньевская</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pen’evskaya</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644080, Омск, Проспект Мира, 7</p><p>Российская Федерация, 644099, Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>7, Prospect Mira, Omsk, 644080, Russian Federation</p><p>12, Lenin St., Omsk, 644099, Russian Federation</p></bio><email xlink:type="simple">nap20052005@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9566-9214</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудаков</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudakov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644080, Омск, Проспект Мира, 7</p><p>Российская Федерация, 644099, Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>7, Prospect Mira, Omsk, 644080, Russian Federation</p><p>12, Lenin St., Omsk, 644099, Russian Federation</p></bio><email xlink:type="simple">mail@oniipi.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6811-9986</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарев</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazarev</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644099, Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>12, Lenin St., Omsk, 644099, Russian Federation</p></bio><email xlink:type="simple">novikovai@omsk-osma.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6091-3424</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михайлова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhailova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644116, Омск, ул. 27-я Северная, 42А</p></bio><bio xml:lang="en"><p>42A, 27th Severnaya St., Omsk, 644116, Russian Federation</p></bio><email xlink:type="simple">epid@mail.omsksanepid.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9099-1287</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федоров</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644116, Омск, ул. 27-я Северная, 42А</p></bio><bio xml:lang="en"><p>42A, 27th Severnaya St., Omsk, 644116, Russian Federation</p></bio><email xlink:type="simple">epid@mail.omsksanepid.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0321-2370</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пневский</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pnevsky</surname><given-names>Y. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российская Федерация, 644001, Омск, ул. 10 лет Октября, 98</p></bio><bio xml:lang="en"><p>98, 10 let Oktyabrya St., Omsk, 644001, Russian Federation</p></bio><email xlink:type="simple">pnevski@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Омский научно-исследовательский институт природно-очаговых инфекций»;&#13;
ФГБОУ ВО «Омский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk Research Institute of Natural Focal Infections;&#13;
Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский государственный медицинский  университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФБУЗ «Центр гигиены и эпидемиологии в Омской области»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Hygiene and Epidemiology in Omsk Region</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Управление Роспотребнадзора по Омской области</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rospotrebnadzor Administration in Omsk Region</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>18</day><month>10</month><year>2020</year></pub-date><volume>0</volume><issue>3</issue><fpage>36</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Блох А.И., Пеньевская Н.А., Рудаков Н.В., Лазарев И.И., Михайлова О.А., Федоров А.С., Пневский Ю.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Блох А.И., Пеньевская Н.А., Рудаков Н.В., Лазарев И.И., Михайлова О.А., Федоров А.С., Пневский Ю.А.</copyright-holder><copyright-holder xml:lang="en">Blokh A.I., Pen’evskaya N.A., Rudakov N.V., Lazarev I.I., Mikhailova O.A., Fedorov A.S., Pnevsky Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/1361">https://journal.microbe.ru/jour/article/view/1361</self-uri><abstract><p>Цель – изучить распространение COVID-19 среди населения Омской области на протяжении 24 недель эпидемического неблагополучия на фоне противоэпидемических мероприятий.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Использованы открытые данные и данные ФБУЗ «Центр гигиены и эпидемиологии в Омской области» по официальному учету и эпидемиологическому расследованию выявленных случаев COVID-19 на территории Омской области за период с 27 марта по 10 сентября 2020 г. Рассчитывали экспоненциальный темп  прироста (r), базовый и эффективный показатели репродукции (R0 и Rt), ожидаемый естественный размах эпидемии и порог коллективного иммунитета. Обработка данных выполнена с использованием MS Excel 2010. Построение картограммы проводилось в приложении QGIS 3.12-Bukuresti в системе координат EPSG: 3576.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. За период с 27 марта по 10 сентября 2020 г. на территории Омской области зарегистрировано 9779 случаев COVID-19, показатель заболеваемости составил 507,6 0/0000 (95 % ДИ 497,5÷517,6), летальность по завершенным случаям – 2,9 %, по выявленным случаям – 2,4 %. Наиболее активное распространение COVID-19 отмечено в Омске и 4 (из 32) районах области (Москаленском, Азовском немецком национальном, Марьяновском, Нововаршавском). На фоне проводимых противоэпидемических мероприятий экспоненциальный темп прироста кумулятивного количества случаев COVID-19 составлял 4,5 % в сутки, R0 – 1,4–1,5, Rt – 1,10. Ожидаемый размах эпидемии при условии продолжения действия ограничительных мер может достигнуть 58,0 % переболевшего населения. Уменьшение количества выявляемых вирусоносителей и неполное выявление COVID-19 среди заболевших  внебольничными пневмониями создают дополнительные риски для скрытого распространения инфекции и осложнения эпидемической ситуации. Сохранение ограничительных мероприятий и превышение порога коллективного иммунитета (28,6 % населения) позволит значительно снизить риски усиления распространения COVID-19  в Омской области. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the spread of COVID-19 among the population of the Omsk Region during 24 weeks of the epidemic on the background of anti-epidemic measures.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A descriptive epidemiological study was carried out based on publically available data и data from the Center for Hygiene and Epidemiology in the Omsk Region on the official registration and epidemiological investigation of detected COVID-19 cases in the Omsk Region for the period from March 27 to September 10, 2020. To assess the potential of COVID-19 to spread, the following indicators were calculated: exponential growth rate (r), basic reproduction number (R0), effective reproduction number (Rt), expected natural epidemic size and herd immunity threshold. Data processing was performed using MS Excel 2010. The cartogram was built using the QGIS 3.12-Bukuresti application in the EPSG: 3576 coordinate system.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. For the period from March 27 to September 10, 2020, a total of 9779 cases of COVID-19 were registered in the Omsk Region, the cumulative incidence was 507,6 per 100000 (95 % CI 497,5÷517,6), the case-fatality rate for completed cases was 2.9 %, for identified cases – 2.4 %. The most active spread of COVID-19 was noted in Omsk and 4 out of 32 districts of the region (Moskalensky, Azov German National, Mariyanovsky, Novovarshavsky). During the ongoing anti-epidemic measures, the exponential growth rate of the cumulative number of COVID-19 cases was 4.5 % per day, R0 – 1.4–1.5, Rt – 1.10, herd immunity threshold – 28.6 %. The expected size of the epidemic in case of sustained anti-epidemic measures can reach 58.0 % of the recovered population. A decrease in the number of detected virus carriers, incomplete detection of COVID-19 among patients with community-acquired pneumonia introduced additional risks for the latent spread of infection and complications of the epidemic situation. Maintaining restrictive  measures and increasing the proportion of the immune population (over 28.6 %) may significantly reduce the risks of increasing the spread of COVID-19 in the Omsk Region. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эпидемиология</kwd><kwd>COVID-19</kwd><kwd>экспоненциальный темп прироста</kwd><kwd>показатель репродукции</kwd><kwd>ожидаемый естественный размах эпидемии</kwd><kwd>порог коллективного иммунитета</kwd></kwd-group><kwd-group xml:lang="en"><kwd>epidemiology</kwd><kwd>COVID-19</kwd><kwd>exponential growth rate</kwd><kwd>reproductive number</kwd><kwd>final size of epidemic</kwd><kwd>herd immunity threshold</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. WHO Director-General's opening remarks at the media briefing on COVID19 – 11 March 2020. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-oncovid-19---11-march-2020.</mixed-citation><mixed-citation xml:lang="en">WHO. WHO Director-General's opening remarks at the media briefing on COVID19 – 11 March 2020. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-oncovid-19---11-march-2020.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Coronavirus disease (COVID-19). Dashboard. (Cited 13.09.20) [Internet]. Available from: https://covid19.who.int/table?tableDay=yesterday&amp;tableChartType=heat.</mixed-citation><mixed-citation xml:lang="en">WHO. WHO Director-General's opening remarks at the media briefing on COVID19 – 11 March 2020. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-oncovid-19---11-march-2020.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wallinga J., Lipsitch M. How generation intervals shape the relationship between growth rates and reproductive numbers. Proc. Biol. Sci. 2007; 274(1609):599–604. DOI: 10.1098/rspb.2006.3754.</mixed-citation><mixed-citation xml:lang="en">WHO. Coronavirus disease (COVID-19). Dashboard. (Cited 13.09.20) [Internet]. Available from: https://covid19.who.int/table?tableDay=yesterday&amp;tableChartType=heat.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Nishiura H., Linton N.M., Akhmetzhanov A.R. Serial interval of novel coronavirus (COVID-19) infections. Int. J. Infect. Dis. 2020; 93:284–6. DOI: 10.1016/j.ijid.2020.02.060.</mixed-citation><mixed-citation xml:lang="en">WHO. Coronavirus disease (COVID-19). Dashboard. (Cited 13.09.20) [Internet]. Available from: https://covid19.who.int/table?tableDay=yesterday&amp;tableChartType=heat.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Park M., Cook A.R., Lim J.T., Sun Y., Dickens B.L. A systematic review of COVID-19 epidemiology based on current evidence. J. Clin. Med. 2020; 9(4):967. DOI: 10.3390/jcm9040967.</mixed-citation><mixed-citation xml:lang="en">Wallinga J., Lipsitch M. How generation intervals shape the relationship between growth rates and reproductive numbers. Proc. Biol. Sci. 2007; 274(1609):599–604. DOI: 10.1098/rspb.2006.3754.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Miller J.C. A note on the derivation of epidemic final sizes. Bull. Math. Biol. 2012; 74(9):2125–41. DOI: 10.1007/s11538-12-9749-6.</mixed-citation><mixed-citation xml:lang="en">Wallinga J., Lipsitch M. How generation intervals shape the relationship between growth rates and reproductive numbers. Proc. Biol. Sci. 2007; 274(1609):599–604. DOI: 10.1098/rspb.2006.3754.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rodpothong P., Auewarakul P. Viral evolution and transmission effectiveness. World J. Virol. 2012; 1(5):131–4. DOI: 10.5501/wjv.v1.i5.131.</mixed-citation><mixed-citation xml:lang="en">Nishiura H., Linton N.M., Akhmetzhanov A.R. Serial interval of novel coronavirus (COVID-19) infections. Int. J. Infect. Dis. 2020; 93:284–6. DOI: 10.1016/j.ijid.2020.02.060.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Cori A., Ferguson N.M., Fraser C., Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am. J. Epidemiol. 2013; 178(9):1505–12. DOI: 10.1093/aje/kwt133.</mixed-citation><mixed-citation xml:lang="en">Nishiura H., Linton N.M., Akhmetzhanov A.R. Serial interval of novel coronavirus (COVID-19) infections. Int. J. Infect. Dis. 2020; 93:284–6. DOI: 10.1016/j.ijid.2020.02.060.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Stolwijk A.M., Straatman H., Zielhuis G.A. Studying seasonality by using sine and cosine functions in regression analysis. J. Epidemiol. Community Health. 1999; 53(4):235–8. DOI: 10.1136/jech.53.4.235.</mixed-citation><mixed-citation xml:lang="en">Park M., Cook A.R., Lim J.T., Sun Y., Dickens B.L. A systematic review of COVID-19 epidemiology based on current evidence. J. Clin. Med. 2020; 9(4):967. DOI: 10.3390/jcm9040967.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation><mixed-citation xml:lang="en">Park M., Cook A.R., Lim J.T., Sun Y., Dickens B.L. A systematic review of COVID-19 epidemiology based on current evidence. J. Clin. Med. 2020; 9(4):967. DOI: 10.3390/jcm9040967.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Miller J.C. A note on the derivation of epidemic final sizes. Bull. Math. Biol. 2012; 74(9):2125–41. DOI: 10.1007/s11538-12-9749-6.</mixed-citation><mixed-citation xml:lang="en">Miller J.C. A note on the derivation of epidemic final sizes. Bull. Math. Biol. 2012; 74(9):2125–41. DOI: 10.1007/s11538-12-9749-6.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Miller J.C. A note on the derivation of epidemic final sizes. Bull. Math. Biol. 2012; 74(9):2125–41. DOI: 10.1007/s11538-12-9749-6.</mixed-citation><mixed-citation xml:lang="en">Miller J.C. A note on the derivation of epidemic final sizes. Bull. Math. Biol. 2012; 74(9):2125–41. DOI: 10.1007/s11538-12-9749-6.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rodpothong P., Auewarakul P. Viral evolution and transmission effectiveness. World J. Virol. 2012; 1(5):131–4. DOI: 10.5501/wjv.v1.i5.131.</mixed-citation><mixed-citation xml:lang="en">Rodpothong P., Auewarakul P. Viral evolution and transmission effectiveness. World J. Virol. 2012; 1(5):131–4. DOI: 10.5501/wjv.v1.i5.131.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rodpothong P., Auewarakul P. Viral evolution and transmission effectiveness. World J. Virol. 2012; 1(5):131–4. DOI: 10.5501/wjv.v1.i5.131.</mixed-citation><mixed-citation xml:lang="en">Rodpothong P., Auewarakul P. Viral evolution and transmission effectiveness. World J. Virol. 2012; 1(5):131–4. DOI: 10.5501/wjv.v1.i5.131.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cori A., Ferguson N.M., Fraser C., Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am. J. Epidemiol. 2013; 178(9):1505–12. DOI: 10.1093/aje/kwt133.</mixed-citation><mixed-citation xml:lang="en">Cori A., Ferguson N.M., Fraser C., Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am. J. Epidemiol. 2013; 178(9):1505–12. DOI: 10.1093/aje/kwt133.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cori A., Ferguson N.M., Fraser C., Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am. J. Epidemiol. 2013; 178(9):1505–12. DOI: 10.1093/aje/kwt133.</mixed-citation><mixed-citation xml:lang="en">Cori A., Ferguson N.M., Fraser C., Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am. J. Epidemiol. 2013; 178(9):1505–12. DOI: 10.1093/aje/kwt133.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Stolwijk A.M., Straatman H., Zielhuis G.A. Studying seasonality by using sine and cosine functions in regression analysis. J. Epidemiol. Community Health. 1999; 53(4):235–8. DOI: 10.1136/jech.53.4.235.</mixed-citation><mixed-citation xml:lang="en">Stolwijk A.M., Straatman H., Zielhuis G.A. Studying seasonality by using sine and cosine functions in regression analysis. J. Epidemiol. Community Health. 1999; 53(4):235–8. DOI: 10.1136/jech.53.4.235.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Stolwijk A.M., Straatman H., Zielhuis G.A. Studying seasonality by using sine and cosine functions in regression analysis. J. Epidemiol. Community Health. 1999; 53(4):235–8. DOI: 10.1136/jech.53.4.235.</mixed-citation><mixed-citation xml:lang="en">Stolwijk A.M., Straatman H., Zielhuis G.A. Studying seasonality by using sine and cosine functions in regression analysis. J. Epidemiol. Community Health. 1999; 53(4):235–8. DOI: 10.1136/jech.53.4.235.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation><mixed-citation xml:lang="en">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation><mixed-citation xml:lang="en">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation><mixed-citation xml:lang="en">WHO. Coronavirus disease (COVID-19). Situation Report – 46. (Cited 29.07.20) [Internet]. Available from: https://www.who.int/docs/default-source/coronavirus/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_4.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
