microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2021-1-87-94microbe-1442Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСравнительный анализ вертикального риска передачи некоторых гемоконтактных инфекций в Гвинейской РеспубликеComparative Analysis of the Vertical Risk of Transmission of Some Blood-Borne Infections in the Republic of GuineaBaldeT.A.L.BaldeT.A.L.

Киндия, Гвинейская Республика

Kindia, Republic of Guinea

https://orcid.org/0000-0002-4506-6033BoumbalyS.BoumbalyS.

Киндия, Гвинейская Республика; Н’Зерекоре, Гвинейская Республика

Kindia, Republic of Guinea; N’Zerekore, Republic of Guinea

https://orcid.org/0000-0002-0547-3945СериковаЕ. Н.SerikovaE. N.

197101, Санкт-Петербург, ул. Мира, 14

14, Mira St., Saint Petersburg, 197101

https://orcid.org/0000-0002-0931-102XВалутитеД. Э.ValutiteD. E.

197101, Санкт-Петербург, ул. Мира, 14

14, Mira St., Saint Petersburg, 197101

https://orcid.org/0000-0002-3139-3674ЩемелевА. Н.ShchemelevA. N.

197101, Санкт-Петербург, ул. Мира, 14

14, Mira St., Saint Petersburg, 197101

https://orcid.org/0000-0003-2270-8897ОстанковаЮ. В.OstankovaYu. V.

197101, Санкт-Петербург, ул. Мира, 14

14, Mira St., Saint Petersburg, 197101

shenna1@yandex.ruhttps://orcid.org/0000-0002-0579-110XЗуеваЕ. Б.ZuevaE. B.

197101, Санкт-Петербург, ул. Мира, 14

14, Mira St., Saint Petersburg, 197101

https://orcid.org/0000-0003-3223-8219СеменовА. В.SemenovA. V.

197101, Санкт-Петербург, ул. Мира, 14

14, Mira St., Saint Petersburg, 197101

Научно-исследовательский институт прикладной биологии ГвинеиГвинеяResearch Institute of Applied BiologyGuineaНаучно-исследовательский институт прикладной биологии Гвинеи; Международный исследовательский центр по тропическим инфекциям в ГвинееГвинеяResearch Institute of Applied Biology; Centre International de Recherche sur les Infections Tropicales en GuinéeGuineaФБУН «Санкт-Петербургский НИИ эпидемиологии и микробиологии имени Пастера»РоссияSaint Petersburg Pasteur Research Institute of Epidemiology and MicrobiologyRussian Federation202116042021018794Copyright © Balde T., Boumbaly S., Серикова Е.Н., Валутите Д.Э., Щемелев А.Н., Останкова Ю.В., Зуева Е.Б., Семенов А.В., 20212021Balde T., Boumbaly S., Серикова Е.Н., Валутите Д.Э., Щемелев А.Н., Останкова Ю.В., Зуева Е.Б., Семенов А.В.Balde T., Boumbaly S., Serikova E.N., Valutite D.E., Shchemelev A.N., Ostankova Y.V., Zueva E.B., Semenov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/1442

Цель работы – сравнение рисков вертикальной передачи вирусов гепатитов B (ВГВ) и C (ВГС), а также вируса иммунодефицита человека (ВИЧ) в Гвинейской Республике.

Материалы и методы

Материалы и методы. Материалом исследования служили 305 образцов плазмы крови беременных женщин, проживающих на территории г. Conakry, Гвинейская Республика. Образцы обследовали на наличие серологических (HBsAg, антитела анти-HBs IgG, анти-HBcore IgG, анти-HCV IgG, Ag/Ab-HIV) и молекулярных (ДНК ВГВ, РНК ВГС, РНК ВИЧ) маркеров.

Результаты и обсуждение

Результаты и обсуждение. При оценке общей распространенности серологических маркеров среди пациентов встречаемость маркеров ВГВ составила 76,06 %. Антитела к ВГС выявлены только в одном случае, что составило 0,32 %. Маркеры ВИЧ выявлены в трех случаях, что составило 0,98 %. В анализируемой группе распространенность HBsAg достоверно отличалась между группами беременных в возрасте 13–19 лет (17,33 %) и 20–24 лет (12,12 %), p<0,0001, RR=5,107 при 95 % ДИ: 2,458–10,612. При оценке общей распространенности молекулярно-биологических маркеров среди пациентов РНК ВИЧ не выявили, у одной пациентки определили РНК ВГС, что составило 0,32 %, в то время как встречаемость ДНК ВГВ составила 20 %. Среди HBsAg-позитивных лиц ДНК ВГВ выявили у 86,11 %, что составило 10,16 % от общей группы. Среди HBsAg-негативных лиц ДНК ВГВ выявили у 11,15 % (9,84 % от общей группы). Отметим, что в девяти случаях ДНК ВГВ выявили при отсутствии каких-либо серологических маркеров, что составило 14,75 %, т.е. 2,95 % от общей группы. Оценка распространенности гемоконтактных инфекций у беременных значима для последующей идентификации путей передачи патогенов с целью контроля и/или предотвращения распространения инфекции.

The aim of our work was to compare the HBV, HCV and HIV vertical transmission risk in the Republic of Guinea.

Materials and methods

Materials and methods. The material for the study was 305 blood plasma samples from pregnant women living in Conakry, Republic of Guinea. The samples were examined for the presence of serological (HBsAg, antibodies antiHBs IgG, anti-HBcore IgG, anti-HCV IgG, Ag/Ab-HIV) and molecular (HBV DNA, HCV RNA, HIV RNA) markers.

Results and discussion

Results and discussion. When assessing the overall prevalence of serological markers among patients, the incidence of HBV markers was 76.06 %. Antibodies to HCV were detected only in 1 case, which amounted to 0.32 %. HIV markers were detected in 3 cases, which amounted to 0.98 %. The prevalence of HBsAg in the group under examination significantly differed between the groups of pregnant women aged 13–19 years (17.33 %) and 20–24 years (12.12 %), p<0.0001, RR=5.107 with 95 % CI: 2.458–10.612. When assessing the overall prevalence of molecular-biological markers among patients, we did not detect HIV RNA, in one patient, HCV RNA was determined, which was 0.32 %, while the incidence of HBV DNA was 20 %. Among HBsAg-positive individuals, HBV DNA was detected in 86.11 %, which was 10.16 % of the total group. Among the HBsAg-negative individuals, HBV DNA was detected in 11.15 % (9.84 % of the total group). It should be noted that in nine cases, HBV DNA was detected without any serological markers, which amounted to 14.75 % (2.95 % of the total group). Assessment of the blood-borne infections prevalence in pregnant women is significant for the subsequent identification of pathogen transmission routes in order to control and/or prevent the spread of infection.

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The authors declare that there are no conflicts of interest present.