<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2022-2-46-53</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-1692</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Эпидемиологическая ситуация по иксодовым клещевым боррелиозам в Российской Федерации в 2021 г. и прогноз на 2022 г</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiological Situation on Tick-Borne Borreliosis in the Russian Federation in 2021 and Forecast for 2022</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6262-129X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудакова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudakova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Рудакова Светлана Анатольевна </p><p>644080, Омск, пр. Мира, 7 </p></bio><bio xml:lang="en"><p> Svetlana A. Rudakova </p><p> 7, Mira Avenue, Omsk, 644080 </p></bio><email xlink:type="simple">svetruda@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1897-5522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теслова</surname><given-names>О. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Teslova</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644080, Омск, пр. Мира, 7</p><p>Омск, ул. Ленина, 12 </p></bio><bio xml:lang="en"><p> 7, Mira Avenue, Omsk, 644080 </p><p> 12, Lenina St., Omsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9572-7792</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муталинова</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mutalinova</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644080, Омск, пр. Мира, 7</p><p>Омск, ул. Ленина, 12 </p></bio><bio xml:lang="en"><p>7, Mira Avenue, Omsk, 644080 </p><p> 12, Lenina St., Omsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7220-4366</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пеньевская</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pen’evskaya</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644080, Омск, пр. Мира, 7</p><p>Омск, ул. Ленина, 12 </p></bio><bio xml:lang="en"><p>7, Mira Avenue, Omsk, 644080 </p><p> 12, Lenina St., Omsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9566-9214</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудаков</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudakov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644080, Омск, пр. Мира, 7</p><p>Омск, ул. Ленина, 12 </p></bio><bio xml:lang="en"><p>7, Mira Avenue, Omsk, 644080 </p><p> 12, Lenina St., Omsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0920-0100</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савельев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Savel’ev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644080, Омск, пр. Мира, 7</p><p>Омск, ул. Ленина, 12 </p></bio><bio xml:lang="en"><p>7, Mira Avenue, Omsk, 644080 </p><p> 12, Lenina St., Omsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8267-7012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьменко</surname><given-names>Ю. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuz’menko</surname><given-names>Yu. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644080, Омск, пр. Мира, 7 </p></bio><bio xml:lang="en"><p>7, Mira Avenue, Omsk, 644080  </p></bio><email xlink:type="simple">mail@oniipi.org</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Омский научно-исследовательский институт природно-очаговых инфекций»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk Research Institute of Natural-Focal Infections</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФБУН «Омский научно-исследовательский институт природно-очаговых инфекций»; ФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk Research Institute of Natural-Focal Infections; Omsk State Medical University, Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>08</day><month>07</month><year>2022</year></pub-date><volume>0</volume><issue>2</issue><fpage>46</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рудакова С.А., Теслова О.Е., Муталинова Н.Е., Пеньевская Н.А., Рудаков Н.В., Савельев Д.А., Кузьменко Ю.Ф., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Рудакова С.А., Теслова О.Е., Муталинова Н.Е., Пеньевская Н.А., Рудаков Н.В., Савельев Д.А., Кузьменко Ю.Ф.</copyright-holder><copyright-holder xml:lang="en">Rudakova S.A., Teslova O.E., Mutalinova N.E., Pen’evskaya N.A., Rudakov N.V., Savel’ev D.A., Kuz’menko Y.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/1692">https://journal.microbe.ru/jour/article/view/1692</self-uri><abstract><p>В России в 2021 г. зарегистрировано 3875 случаев заболеваний иксодовыми клещевыми боррелиозами (ИКБ ) (2,65 на 100 тыс. населения). По сравнению с 2020 г. снижение заболеваемости в 2021 г. произошло в 61 из 78 субъектов. За прошедший год наибольшее количество заболевших зарегистрировано в Центральном федеральном округе (ЦФО) – 1797 случаев, что составляет 46,4 % заболевших в России. На второй позиции по количеству случаев ИКБ находится Сибирский федеральный округ (СФО) – 616 заболевших (15,9 %), затем Уральский (УФО) – 445 случаев (11,5 %), Северо-Западный (СЗ ФО) – 418 (10,8 %), Приволжский (ПФО) – 388 (10 %). В Д альневосточном (ДФО) и Южном (ЮФО) федеральных округах зарегистрировано 134 (3,5 %) и 60 (1,5 % от общего числа случаев ИКБ ) заболевших соответственно. Последнее место по количеству заболевших клещевыми боррелиозами в 2021 г. занимает Северо-Кавказский федеральный округ (СК ФО), удельный вес которого в общей структуре заболевших в России составляет 0,4 % (зарегистрировано 17 случаев). При оценке многолетней динамики инцидентности ИКБ выявлена достоверная тенденция к снижению интенсивности эпидемического процесса для СЗ ФО, УФО и ПФО, в отличие от ЦФО и ЮФО, где отмечена достоверная тенденция к росту. Для Российской Федерации в целом, СФО, ДФО и СК ФО наиболее вероятно в ближайшей перспективе варьирование показателей заболеваемости в пределах доверительных интервалов среднемноголетних значений.</p></abstract><trans-abstract xml:lang="en"><p>3875 cases of tick-borne borreliosis (TBB) (2.65 per 100000 of population) were recorded in Russia in 2021. Compared to 2020, 61 out of 78 constituent entities experienced a decrease in the incidence rate in 2021. Over the past year, the largest number of cases was registered in the Central Federal District (CFD) – 1797 cases, which is 46.4 % of cases in Russia. Second in the rank by the number of cases of TBB comes the Siberian FD (SFD) – 616 cases (15.9 %), followed by Ural FD – 445 cases (11.5 %), the North-Western FD – 418 (10.8 %), and the Volga FD – 388 (10 %). 134 (3.5 %) and 60 (1.5 % of the total number of cases of TBB) cases were registered in the Far Eastern and Southern Federal Districts, respectively. The last place is occupied by the North Caucasus Federal District (NCFD), where 17 cases were registered, the share of which in the total structure of cases in Russia is 0.4 %. When assessing the long-term dynamics of TBB incidence, a significant trend towards a decrease in the intensity of the epidemic process has been revealed for the North-Western FD, UFD and VFD, as opposed to the CFD and Southern FD, where a significant upward trend was noted. For the Russian Federation on the whole, the Siberian FD, FEFD and NCFD the variation in the incidence rates within the confidence intervals of the long-term annual average values is most likely to be observed in the near future.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>иксодовые клещевые боррелиозы (болезнь Лайма)</kwd><kwd>заболеваемость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Ixodidae tick-borne borrelioses (Lyme disease)</kwd><kwd>morbidity rates</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Коренберг Э.И. Инфекции, передающиеся иксодовыми клещами в лесной зоне, и стратегия их профилактики: изменение приоритетов. Эпидемиология и вакцинопрофилактика. 2013; 5:7–17.</mixed-citation><mixed-citation xml:lang="en">Korenberg E.I. [Infections transmitted by ticks in the forest area and the strategy of their prevention: change of priorities]. Epidemiologiya i Vaktsinoprofilaktika [Epidemiology and Vaccinal Prevention]. 2013; (5):7–17.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Платонов А.Е., Авксентьев Н.А., Авксентьева М.В., Деркач Е.В., Платонова О.В., Титков А.В., Колясникова Н.М. Социально-экономическое бремя пяти природно-очаговых инфекций в Российской Федерации. Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2015; 8(1):47–56. DOI: 10.17749/2070-4909.2015.8.1.047-056.</mixed-citation><mixed-citation xml:lang="en">Platonov A.E., Avksent’ev N.A., Avksent’eva M.V., Derkach E.V., Platonova O.V., Titkov A.V., Kolyasnikova N.M. [Socialeconomic burden of five natural-focal infections in the Russian Federation]. Farmakoekonomika. Sovremennaya Farmakoekonomika i Farmakoepidemiologiya [Pharmacoeconomics. Modern Pharmacoeconomics and Pharmacoepidemiology]. 2015; 8(1):47–56. DOI: 10.17749/2070-4909.2015.8.1.047-056.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Рудакова С.А., Теслова О.Е., Канешова Н.Е., Штрек С.В., Якименко В.В., Пеньевская Н.А. Геновидовое разнообразие боррелий в иксодовых клещах на территории юга Западной Сибири. Проблемы особо опасных инфекций. 2019; 4:92–6. DOI: 10.21055/0370-1069-2019-4-92-96.</mixed-citation><mixed-citation xml:lang="en">Rudakova S.A., Teslova O.E., Kaneshova N.E., Shtrek S.V., Yakimenko V.V., Pen’evskaya N.A. [Genospecies diversity of borrelia in ixodes ticks of the West Siberia]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2019; (4):92–6. DOI: 10.21055/0370-1069-2019-4-92-96.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Stanek G., Wormser G.P., Gray J., Strle F. Lyme borreliosis. Lancet. 2012; 379(9814):461–73. DOI: 10.1016/S01406736(11)60103-7.</mixed-citation><mixed-citation xml:lang="en">Stanek G., Wormser G.P., Gray J., Strle F. Lyme borreliosis. Lancet. 2012; 379(9814):461–73. DOI: 10.1016/S01406736(11)60103-7.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wang G. Borrelia burgdorferi and other Borrelia species. In: Tang Y.W., Sussman M., Liu D., Poxton I.R., Schwartzman J., editors. Molecular Medical Microbiology. 2nd edition. Boston: Academic Press; 2015. Vol. 3. P. 1867–909. DOI: 10.1016/B978-012-397169-2.00104-9.</mixed-citation><mixed-citation xml:lang="en">Wang G. Borrelia burgdorferi and other Borrelia species. In: Tang Y.W., Sussman M., Liu D., Poxton I.R., Schwartzman J., editors. Molecular Medical Microbiology. 2nd edition. Boston: Academic Press; 2015. Vol. 3. P. 1867–909. DOI: 10.1016/B978-012-397169-2.00104-9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wang G., Liveris D., Mukherjee P., Jungnick S., Margos G., Schwartz I. Molecular typing of Borrelia burgdorferi. Curr. Protoc. Microbiol. 2014; 34(1):12C.5.1-31. DOI: 10.1002/9780471729259.mc12c05s34.</mixed-citation><mixed-citation xml:lang="en">Wang G., Liveris D., Mukherjee P., Jungnick S., Margos G., Schwartz I. Molecular typing of Borrelia burgdorferi. Curr. Protoc. Microbiol. 2014; 34(1):12C.5.1-31. DOI: 10.1002/9780471729259.mc12c05s34.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sprong H., Azagi T., Hoornstra D., Nijhof A.M., Knorr S., Baarsma M.E., Hovius J.W. Control of Lyme borreliosis and other Ixodes ricinus-borne diseases. Parasit. Vectors. 2018; 11(1):145. DOI: 10.1186/s13071-018-2744-5.</mixed-citation><mixed-citation xml:lang="en">Sprong H., Azagi T., Hoornstra D., Nijhof A.M., Knorr S., Baarsma M.E., Hovius J.W. Control of Lyme borreliosis and other Ixodes ricinus-borne diseases. Parasit. Vectors. 2018; 11(1):145. DOI: 10.1186/s13071-018-2744-5.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Estrada-Pena A., Cutler S., Potkonjak A., Vassier-Tussaut M., Van Bortel W., Zeller H., Fernandez-Ruiz N., Mihalca A.D. An updated meta-analysis of the distribution and prevalence of Borrelia burgdorferi s.l. in ticks in Europe. Int. J. Health Geogr. 2018; 17(1):41. DOI: 10.1186/s12942-018-0163-7.</mixed-citation><mixed-citation xml:lang="en">Estrada-Peña A., Cutler S., Potkonjak A., Vassier-Tussaut M., Van Bortel W., Zeller H., Fernández-Ruiz N., Mihalca A.D. An updated meta-analysis of the distribution and prevalence of Borrelia burgdorferi s.l. in ticks in Europe. Int. J. Health Geogr. 2018; 17(1):41. DOI: 10.1186/s12942-018-0163-7.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Steere A.C., Strle F., Wormser G.P., Hu L.T., Branda J.A., Hovius J.W., Li X., Mead P.S. Lyme borreliosis. Nat. Rev. Dis. Primers. 2016; 2:16090. DOI: 10.1038/nrdp.2016.90.</mixed-citation><mixed-citation xml:lang="en">Steere A.C., Strle F., Wormser G.P., Hu L.T., Branda J.A., Hovius J.W., Li X., Mead P.S. Lyme borreliosis. Nat. Rev. Dis. Primers. 2016; 2:16090. DOI: 10.1038/nrdp.2016.90.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sykes R.A., Makiello P. An estimate of Lyme borreliosis incidence in Western Europe. J. Public Health (Oxf.). 2017; 39(1):74– 81. DOI: 10.1093/pubmed/fdw017.</mixed-citation><mixed-citation xml:lang="en">Sykes R.A., Makiello P. An estimate of Lyme borreliosis incidence in Western Europe. J. Public Health (Oxf.). 2017; 39(1):74– 81. DOI: 10.1093/pubmed/fdw017.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Манзенюк И.Н., Манзенюк О.Ю. Клещевые боррелиозы (болезнь Лайма). Кольцово; 2005. 85 с.</mixed-citation><mixed-citation xml:lang="en">Manzenyuk I.N., Manzenyuk O.Yu. [Tick-Borne Borreliosis (Lyme Disease)]. Kol’tsovo; 2005. 85 p.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Глобальные меры по борьбе с переносчиками инфекций на 2017–2030 гг. (версия 5.4). Справочно-информационный документ для обсуждения на 70-й сессии Всемирной ассамблеи здравоохранения. ВОЗ ; 2017. [Электронный ресурс]. URL: https://apps.who.int/iris/bitstream/handle/10665/274856/A70_26Rev1-ru.pdf.</mixed-citation><mixed-citation xml:lang="en">[Global vector control measures for 2017–2030 (version 5.4). Background paper for discussion at the 70th World Health Assembly]. WHO; 2017. [Internet]. Available from: https://apps.who.int/iris/bitstream/handle/10665/274856/A70_26Rev1-ru.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Рудакова С.А., Пеньевская Н.А., Рудаков Н.В., Пакскина Н.Д., Савельев Д.А., Блох А.И. Интенсивность и тенденции развития эпидемического процесса иксодовых клещевых боррелиозов в Российской Федерации в 2002–2018 гг. и прогноз на 2019 г. Проблемы особо опасных инфекций. 2019; 2:22–9. DOI: 10.21055/0370-1069-2019-2-22-29.</mixed-citation><mixed-citation xml:lang="en">Rudakova S.A., Pen’evskaya N.A., Rudakov N.V., Pakskina N.D., Savel’ev D.A., Blokh A.I. [Intensity and trends in development of epidemic process of Ixodes tick-borne borrelioses in the Russian Federation in 2002–2018 and forecast for 2019]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2019; (2):22–9. DOI: 10.21055/0370-1069-2019-2-22-29.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Савилов Е.Д., Астафьев В.А., Жданова С.Н., Заруднев Е .А. Эпидемиологический анализ. Методы статистической обработки материала. Новосибирск: Наука-центр; 2011. 156 с.</mixed-citation><mixed-citation xml:lang="en">Savilov E.D., Astaf’ev V.A., Zhdanova S.N., Zarudnev E.A. [Epidemiological Analysis. Methods of Statistical Data Processing]. Novosibirsk: “Science Center”; 2011. 156 p.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М.: МедиаСфера; 2000. 312 с.</mixed-citation><mixed-citation xml:lang="en">Rebrova O.Yu. [Statistical Analysis of Medical Data. Using the STATISTICA Application Package]. Moscow: “Mediasphere”; 2000. 312 p.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ланг Т.А., Сесик М. Как описывать статистику в медицине. Руководство для авторов, редакторов и рецензентов. М.: Практическая медицина; 2011. 477 с.</mixed-citation><mixed-citation xml:lang="en">Lang T.A., Sessic M. [How to Describe Statistics in Medicine. Annotated Guide for Authors, Editors, and Reviewers]. Moscow: “Practical Medicine”; 2011. 477 p.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
