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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2023-4-77-83</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-1900</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Серомониторинг маркеров вирусов гриппа с пандемическим потенциалом в Российской Федерации в 2021–2023 гг.</article-title><trans-title-group xml:lang="en"><trans-title>Serological Monitoring of Pandemic Influenza Virus Markers in the Russian Federation in 2021–2023</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2354-7688</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильичева</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilyicheva</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630559, Новосибирская обл., р.п. Кольцово</p></bio><bio xml:lang="en"><p>Kol’tsovo, Novosibirsk Region, 630559</p></bio><email xlink:type="simple">ilicheva_tn@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseeva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630559, Новосибирская обл., р.п. Кольцово</p></bio><bio xml:lang="en"><p>Kol’tsovo, Novosibirsk Region, 630559</p></bio><email xlink:type="simple">vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630559, Новосибирская обл., р.п. Кольцово</p></bio><bio xml:lang="en"><p>Kol’tsovo, Novosibirsk Region, 630559</p></bio><email xlink:type="simple">vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2587-4559</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азаев</surname><given-names>М. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Azaev</surname><given-names>M. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630559, Новосибирская обл., р.п. Кольцово</p></bio><bio xml:lang="en"><p>Kol’tsovo, Novosibirsk Region, 630559</p></bio><email xlink:type="simple">vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1339-6732</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марченко</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Marchenko</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="en"><p>Kol’tsovo, Novosibirsk Region, 630559</p></bio><email xlink:type="simple">vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Государственный научный центр вирусологии и биотехнологии «Вектор»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Center of Virology and Biotechnology “Vector”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2024</year></pub-date><volume>0</volume><issue>4</issue><fpage>77</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ильичева Т.Н., Моисеева А.А., Иванова К.И., Азаев М.Ш., Марченко В.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ильичева Т.Н., Моисеева А.А., Иванова К.И., Азаев М.Ш., Марченко В.Ю.</copyright-holder><copyright-holder xml:lang="en">Ilyicheva T.N., Moiseeva A.A., Ivanova K.I., Azaev M.S., Marchenko V.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/1900">https://journal.microbe.ru/jour/article/view/1900</self-uri><abstract><p>В ФБУН ГНЦ ВБ «Вектор» Роспотребнадзора с 2005 г. проводится надзор за высокопатогенным гриппом.</p><p>Цель работы – мониторинг маркеров вирусов гриппа с пандемическим потенциалом в сыворотках крови людей, имевших контакт с больной и/или погибшей птицей, а также жителей регионов, где наиболее вероятно появление новых вариантов вируса гриппа А.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Сыворотки исследованы в реакции торможения гемагглютинации (РТГА). Положительные в РТГА сыворотки тестированы в реакции нейтрализации.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. В 2021 г. было собрано 2076 образцов сыворотки крови в 19 регионах Российской Федерации. Только 7 образцов имели значимые титры в РТГА с вирусами А/H5N8. В 2022 г. собрано 1620 образцов сыворотки крови в 23 регионах, 25 из них были положительными к вирусам гриппа А/H5N8 и А/H5N1. В январе – августе 2023 г. собрано 3335 образцов сыворотки в 31 регионе РФ, 28 из них были положительными к вирусам гриппа А/H5N8 и А/H5N1. Также проводится серомониторинг в отношении низкопатогенного вируса субтипа А/H9N2. Количество серопозитивных образцов в 2021 г. было ниже 1 % (13 из 2076 образцов), в 2022 г. – 5,0 % (81 из 1620 образцов), в 2023 г. позитивных образцов – менее 1 % (31 из 3335 образцов). Полученные данные косвенно свидетельствуют, что в настоящее время среди населения Российской Федерации нет стабильной циркуляции вирусов зоонозного гриппа субтипов А/H5N8 и А/H5N1. Вирус гриппа субтипа А/H9N2 широко распространился во многих странах мира и активно участвует в эволюции высокопатогенных субтипов вируса гриппа А/H5Nх. В РФ наблюдается постепенное увеличение серопозитивности к вирусу А/H9N2.</p></sec></abstract><trans-abstract xml:lang="en"><p>State Scientific Center of Virology and Biotechnology “Vector” has been monitoring highly pathogenic influenza since 2005.</p><p>The aim of this work was to track the markers of highly pathogenic influenza in the blood sera of people who had a contact with infected and/or deceased birds, as well as of residents from regions where emergence of new variants of influenza A virus is most likely to occur.</p><sec><title>Materials and methods</title><p>Materials and methods. Sera were studied using hemagglutination inhibition test (HI test). HI-positive sera were subjected to virus neutralization reaction.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. In 2021, 2076 blood serum samples from 19 regions of Russia were collected. Only 7 samples demonstrated significant titers in HI test with A/H5N8 viruses. In 2022, 1620 blood serum samples from 23 regions were obtained; 25 of them were positive for influenza А/H5N8 and А/H5N1 viruses. In 2023 (January-August), 3335 serum samples from 31 regions of the Russian Federation were collected. 28 samples were positive for influenza А/H5N8 and А/H5N1 viruses. Furthermore, we monitored blood sera for low-pathogenic A/H9N2 virus. The number of positive samples in 2021 was lower than 1 % (13 out of 2076); in 2022, it reached 5 % (81 out of 1620); in 2023, the share was lower than 1 % (31 out of 3335). The data obtained suggest indirectly that currently there is no stable circulation of zoonotic influenza A/H5N8 and A/H5N1 viruses in Russia. Influenza viruses A/H9N2 have widely spread in many countries of the world and actively participate in evolution of highly pathogenic influenza A/H5Nx viruses. The Russian Federation demonstrates a gradual increase in the number of blood serum samples with antibodies to A/H9N2 virus.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>надзор за вирусами гриппа</kwd><kwd>сыворотки крови людей</kwd><kwd>антитела к вирусам зоонозного гриппа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>surveillance of influenza viruses</kwd><kwd>human blood sera</kwd><kwd>antibodies to zoonotic influenza viruses</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ilyicheva T., Sobolev I., Susloparov I., Kurskaya O., Durymanov A., Sharshov K., Shestopalov A. Monitoring of influenza viruses in Western Siberia in 2008–2012. Infect. Genet. Evol. 2013; 20:177–87. DOI: 10.1016/j.meegid.2013.08.025.</mixed-citation><mixed-citation xml:lang="en">Ilyicheva T., Sobolev I., Susloparov I., Kurskaya O., Durymanov A., Sharshov K., Shestopalov A. 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