microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2024-3-25-34microbe-2038Research ArticleОБЗОРЫREVIEWSАварии в лабораториях, осуществляющих работы с патогенными биологическими агентамиAccidents in Laboratories Working with Pathogenic Biological Agentshttps://orcid.org/0009-0003-7100-9088КрепостноваИ. М.KrepostnovaI. M.

Крепостнова Ирина Михайловна

Российская Федерация, 410005, Саратов, ул. Университетская, 46

46, Universitetskaya St., Saratov, 410005, Russian Federation

rusrapi@microbe.ruhttps://orcid.org/0000-0003-3726-810XГордееваМ. В.GordeevaM. V.

Российская Федерация, 410005, Саратов, ул. Университетская, 46

46, Universitetskaya St., Saratov, 410005, Russian Federation

ФКУН «Российский научно-­исследовательский противочумный институт «Микроб»РоссияRussian Research Anti-Plague Institute “Microbe”Russian Federation202427092024032534Copyright © Крепостнова И.М., Гордеева М.В., 20242024Крепостнова И.М., Гордеева М.В.Krepostnova I.M., Gordeeva M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/2038

Аварии при работе с возбудителями инфекционных болезней являются одним из ведущих факторов биологического риска для сотрудников, населения и окружающей среды. Специалистам в области биологической безопасности следует проводить мониторинг и анализ информации по авариям при работе с патогенными биологическими агентами с целью применения результатов для формирования устойчивой системы обеспечения биобезопасности как на объектовом, так и федеральном уровне. Для получения информации, необходимой для анализа причин и условий возникновения аварий, проведен поиск открытых данных в интернете. Обнаружено, что более обширно и доступно соответствующие сведения представлены в зарубежных источниках. Изучена информация об авариях, произошедших за рубежом с 2010 по 2023 г. Аварии, связанные с нарушением кожных покровов, наиболее часто являются очевидной причиной лабораторного заражения. Преобладают сообщения о подобных авариях, вызванных уколом инъекционной иглы. Аварии, связанные с нарушением средств индивидуальной защиты (разрыв перчаток), явились потенциальной причиной заражения при сопряженном нарушении целости кожных покровов или в случае имеющихся на момент аварии поражений кожи. Описаны случаи нарушения целости изолирующих средств индивидуальной защиты. Сообщения, описывающие аварии «с разбрызгиванием» и «без разбрызгивания» (в интерпретации российских нормативов), не обнаружены. Среди описанных случаев бóльшая часть связана с нарушением различных требований биологической безопасности.

Accidents during the work with infectious disease agents are one of the leading biological risk factors for employees, the public and the environment. Specialists in the field of biological safety should monitor and analyze information on these accidents in order to use the findings and implications to form a sustainable biosafety system both, at the facility and at the federal levels. To obtain the necessary information to analyze the causes and conditions of accidents, we have carried out a search of open data on the Internet. It has been found that the relevant information is more extensively and accessibly presented in foreign sources. Information on accidents that occurred abroad between 2010 and 2023 has been studied. Accidents associated with skin penetration and lesions were most often the obvious cause of laboratory acquired infection. Reports of similar accidents caused by injection needle sticks predominated. Accidents associated with breach of personal protective equipment (torn gloves) were a potential cause of infection when there was a concurrent violation of the skin integrity or in the case of skin lesions existing at the time of the accident. Cases of violation of the integrity of insulating personal protective equipment were described. Reports on accidents “with spillage” and “without spillage” (as stated in the Russian normative documents) have not been found. Among the investigated cases, most are associated with violations of various biological safety requirements.

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The authors declare that there are no conflicts of interest present.