microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2015-3-77-82microbe-250Research ArticleМИКРОБИОЛОГИЯMICROBIOLOGYМолекулярно-генетические особенности строения генома представителей рода EbolavirusThe Molecular Genetic Peculiarities of Genomic Structure of Members of the Ebolavirus GenusПетровА. А.PetrovA. A.noemail@neicon.ruЛебедевВ. Н.LebedevV. N.noemail@neicon.ruСтовбаЛ. Ф.StovbaL. F.noemail@neicon.ruСизиковаТ. Е.SizikovaT. E.noemail@neicon.ruПлехановаТ. М.PlekhanovaT. M.noemail@neicon.ruСидороваО. Н.SidorovaO. N.noemail@neicon.ruПышнаяН. С.PyshnayaN. S.noemail@neicon.ruПавельевД. И.PavelievD. I.noemail@neicon.ruБорисевичС. В.BorisevichS. V.noemail@neicon.ru48 Центральный научно-исследовательский институт Министерства обороныРоссия48 Central Research Institute of the Ministry of Defense of the Russian FederationRussian Federation201520092015037782Copyright © Петров А.А., Лебедев В.Н., Стовба Л.Ф., Сизикова Т.Е., Плеханова Т.М., Сидорова О.Н., Пышная Н.С., Павельев Д.И., Борисевич С.В., 20152015Петров А.А., Лебедев В.Н., Стовба Л.Ф., Сизикова Т.Е., Плеханова Т.М., Сидорова О.Н., Пышная Н.С., Павельев Д.И., Борисевич С.В.Petrov A.A., Lebedev V.N., Stovba L.F., Sizikova T.E., Plekhanova T.M., Sidorova O.N., Pyshnaya N.S., Paveliev D.I., Borisevich S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/250

Рассмотрены молекулярно-генетические особенности структуры генома представителей рода Ebolavirus. Отмечено, что эпидемические вспышки лихорадки Эбола в Африке представляют потенциальную угрозу для здравоохранения не только стран этого континента, но и всего мира, вследствие возможности завоза возбудителя в неэндемичные регионы. Представители рода Ebolavirus обладают различной патогенностью для человека, что определяет различия показателей смертности и тяжести болезни. Между представителями рода Ebolavirus имеется значительная генетическая дивергенция. Изменение патогенного потенциала представителей рода Ebolavirus может быть объяснено мутациями в генах структурных белков вируса. Вероятно, некоторые мутации в этих генах могут оказывать влияние на вирулентность штаммов в пределах одного вида вируса. Поскольку наиболее эффективные имеющиеся на сегодняшний день средства экстренной профилактики и лечения имеют строго дифференцированную направленность, генотипирование представляет большое значение при разработке стратегии создания таких препаратов.

The molecular genetic peculiarities of genomic structure of the Ebolavirus genus members are viewed in the review. The Ebola virus disease outbreaks in West African countries constitute a threat not only for Africa, but for the whole world in view of possible introduction of the agent in non-endemic regions. The members of the Ebolavirus genus have different pathogenicity for humans, thus differ severity and mortality of the disease they cause. There is a significant genetic divergence among members of the Ebolavirus genus. The differences of pathogenic potential of members of the Ebolavirus genus may be explained as the result of mutations in the genes of virus structural proteins. It is possible, that some of these mutations may affect virulence of strains within one virus species. So far as most effective modern medicines for specific prophylaxis and treatment of Ebola fever are target-oriented, genotyping of the agent will promote elaboration of strategy of such preparations development.

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The authors declare that there are no conflicts of interest present.