microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2016-1-68-74microbe-289Research ArticleМИКРОБИОЛОГИЯMICROBIOLOGYСидерофоры Bacillus anthracisBacillus anthracis SiderophoresЕременкоЕ. И.EremenkoE. I.snipchi@mail.stv.ruСтавропольский научно-исследовательский противочумный институтРоссияStavropol Research Anti-Plague InstituteRussian Federation201620032016016874Copyright © Еременко Е.И., 20162016Еременко Е.И.Eremenko E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/289

Железо необходимо для роста и размножения бактерий. Один из способов приобретения железа Bacillus anthracis состоит в использовании высокоаффинных хелатирующих агентов ионов железа - сидерофоров бациллибактина и петробактина, извлекающих железо из трансферрина и ферритина клеток хозяина. Функции бациллибактина и петробактина реализуются на разных стадиях роста B. anthracis in vivo , при этом синтез петробактина необходим также и для проявления вирулентности микроба. Знание путей биосинтеза сидерофоров способствует разработке блокирующих эти пути новых терапевтических средств против сибирской язвы. В обзоре приведены сведения о структуре, генетике, функциях сидерофоров сибиреязвенного микроба.

Iron is an essential for growth and reproduction of bacteria element. One of the ways of its acquisition by Bacillus anthracis is utilization of high-affinity chelating agents of iron ions - bacillibactin and petrobactin siderophores, extracting the iron from transferring and ferritin of a host cell. Bacillibactin and petrobactin functions are realized on different stages of B. anthracis growth in vivo, whereas petrobactin synthesis is also necessary for manifestation of microbe virulence. Awareness of siderophore biosynthesis pathways facilitates the development of medicines against anthrax, which can block them up. The review contains the data on the structure, genetics, and functions of B. anthracis siderophores.

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The authors declare that there are no conflicts of interest present.