microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2016-3-21-26microbe-320Research ArticleОБЗОРЫREVIEWSДиагностика острой лихорадки с тромбоцитопеническим синдромом – болезни, вызываемой новым флебовирусомDiagnostics of Severe Fever with Thrombocytopenia Syndrome – Disease, Caused by Novel PhlebovirusСизиковаТ. Е.SizikovaT. E.

141306, Московская область, г. С ергиев Посад-6, ул. О ктябрьская, д. 11

48cnii@mil.ruЛебедевВ. Н.LebedevV. N.

141306, Московская область, г. С ергиев Посад-6, ул. О ктябрьская, д. 11

БоярскаяН. В.BoyarskayaN. V.

141306, Московская область, г. С ергиев Посад-6, ул. О ктябрьская, д. 11

БорисевичС. В.BorisevichS. V.

141306, Московская область, г. С ергиев Посад-6, ул. О ктябрьская, д. 11

ФГБУ «48 Центральный научно-исследовательский институт» Министерства обороныРоссияThe 48th Central Research Institute of the Ministry of Defense of the Russian FederationRussian Federation201620092016032126Copyright © Сизикова Т.Е., Лебедев В.Н., Боярская Н.В., Борисевич С.В., 20162016Сизикова Т.Е., Лебедев В.Н., Боярская Н.В., Борисевич С.В.Sizikova T.E., Lebedev V.N., Boyarskaya N.V., Borisevich S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/320

В 2009 г. в КНР от больного был выделен новый вирус, получивший название вирус острой лихорадки с тромбоцитопеническим синдромом (SFTS). Болезнь, вызываемая этим вирусом, характеризуется острой лихорадкой, поражениями респираторного и желудочно-кишечного тракта, сопровождается прогрессирующей тромбоцитопенией, лейкопенией, летальностью в 6–30 % случаев. Секвенирование генома выделенного возбудителя установило, что вирус SFTS относится к новой (третьей) группе рода Phlebovirus семейства Bunyaviridae. В настоящее время для специфической диагностики SFTS разработаны различные методы (обратная транскрипция-полимеразная цепная реакция, непрямой метод флуоресцирующих антител, иммуноферментный анализ). В обзоре рассмотрена разработка диагностических наборов и основные характеристики методов выявления возбудителя инфекции и специфических антител к нему.

In 2009, a novel virus, named severe fever with thrombocytopenia syndrome (SFTS) virus, was isolated from a patient in China. The illness caused by this novel virus is characterized by a sudden onset of fever and respiratory or gastrointestinal disorders, followed by progressive thrombocytopenia and leucocytopenia, the case-fatality rate amounting to 6–30 %. Genomic sequencing of the isolated agent indicated that the SFTS virus constituted a new (third) group of Phlebovirus genus, Bunyaviridae family. Presently, different means for specific diagnostics of SFTS (real-time reverse transcription polymerase chain reaction, indirect fluorescent antibodies method, enzyme-linked immune-sorbent assay) are developed. Constructing of diagnostic kits, basic characteristics of methods for determination of causative agent of infection or specific antibodies against it are considered in this review.

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The authors declare that there are no conflicts of interest present.