microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2017-2-50-53microbe-391Research ArticleМИКРОБИОЛОГИЯMICROBIOLOGYМОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИЕ ОСОБЕННОСТИ РЕПРОДУКЦИИ АРЕНАВИРУСОВ В ЧУВСТВИТЕЛЬНЫХ КЛЕТКАХMOLECULAR-BIOLOGICAL PECULIARITIES OF ARENAVIRUS REPRODUCTION IN SENSITIVE CELLSСизиковаТ. Е.SizikovaT. E.

141306, Московская область, г. Сергиев Посад-6, ул. Октябрьская, д. 11

48cnii@mil.ruЛебедевВ. Н.LebedevV. N.

141306, Московская область, г. Сергиев Посад-6, ул. Октябрьская, д. 11

48cnii@mil.ruПантюховВ. Б.PantyukhovV. B.

141306, Московская область, г. Сергиев Посад-6, ул. Октябрьская, д. 11

48cnii@mil.ruАндрусА. Ф.AndrusA. F.

141306, Московская область, г. Сергиев Посад-6, ул. Октябрьская, д. 11

48cnii@mil.ruБорисевичС. В.BorisevichS. V.

141306, Московская область, г. Сергиев Посад-6, ул. Октябрьская, д. 11

48cnii@mil.ru48 Центральный научно-исследовательский институт Министерства обороны Российской ФедерацииРоссияThe 48th Central Research Institute of the Ministry of Defense of the Russian FederationRussian Federation201720062017025053Copyright © Сизикова Т.Е., Лебедев В.Н., Пантюхов В.Б., Андрус А.Ф., Борисевич С.В., 20172017Сизикова Т.Е., Лебедев В.Н., Пантюхов В.Б., Андрус А.Ф., Борисевич С.В.Sizikova T.E., Lebedev V.N., Pantyukhov V.B., Andrus A.F., Borisevich S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/391

Семейство Arenaviridae представляет собой большую группу РНК-содержащих вирусов, геномная РНК которых состоит из двух сегментов и обладает амбисенсной стратегией кодирования. В ходе изучения молекулярно-биологических особенностей репродукции установлено, что при проникновении аренавирусов в клетку задействованы многочисленные молекулярные механизмы белкового взаимодействия. Проникновение аренавирусов в клетки инициируется взаимодействием вирусного гликопротеина с одним или несколькими рецепторами на поверхности клетки-хозяина. Главные клеточные факторы, задействованные в процессе проникновения филовирусов в клетки, это факторы прикрепления (α-дистрогликан для аренавирусов Старого Света и трансфериновый рецептор 1 человека для аренавирусов Нового Света), эндолизосомальные факторы клетки-хозяина (белок Неймана-Пика C1). В обзоре обобщены современные знания относительно роли структурных компонентов аренавирусов и некоторых клеточных факторов на патогенез заболеваний, вызываемых аренавирусами. 

The Arenaviridae family consists of a large group of single strand ambisense RNA viruses that are separated phylogenetically, serologically and geographically into Old World and New World viruses. Recent studies indicate that cellular entry of arenaviruses requires a series of cellular protein interaction and molecular mechanisms. The arenaviruses entry into cells is initiated by the interaction of viral glycoprotein with one or more receptors on the surface of host cells. The main host cell factors that are involved in filovirus entry are attachment factors (α-dystroglycan for Old World and human transferrin receptor 1 for New World viruses), endolisosomal host cell factors (cathepsins B and L and Niemann-Pick C1 protein). The review presents the modern knowledge about the role of structural proteins of arenaviruses and some cell factors in pathogenesis of the diseases, caused by arenaviruses. 

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The authors declare that there are no conflicts of interest present.