<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2018-1-22-29</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-455</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Туляремия: актуальные вопросы и прогноз эпидемической ситуации  на территории Российской Федерации в 2018 г.</article-title><trans-title-group xml:lang="en"><trans-title>Tularemia: Relevant Issues and Forecast of Epidemic Situation in the Territory of the Russian Federation in 2018</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудрявцева</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryavtseva</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оболенск.</p></bio><bio xml:lang="en"><p>Obolensk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мокриевич</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mokrievich</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оболенск.</p></bio><bio xml:lang="en"><p>Obolensk.</p></bio><email xlink:type="simple">mokrievich@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пакскина</surname><given-names>Н. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Pakskina</surname><given-names>N. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Холин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kholin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иркутск.</p></bio><bio xml:lang="en"><p>Irkutsk.</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазепа</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazepa</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иркутск.</p></bio><bio xml:lang="en"><p>Irkutsk.</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликалова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikalova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иркутск.</p></bio><bio xml:lang="en"><p>Irkutsk.</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Транквилевский</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Trankvilevsky</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Храмов</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khramov</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оболенск.</p></bio><bio xml:lang="en"><p>Obolensk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дятлов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyatlov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оболенск.</p></bio><bio xml:lang="en"><p>Obolensk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Государственный научный центр прикладной микробиологии и биотехнологии».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Center of Applied Microbiology and Biotechnology.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФКУЗ «Противочумный центр».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Plague Control Center of the Rospotrebnadzor.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральная служба  по надзору в сфере защиты прав потребителей и благополучия человека.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФКУЗ «Научно-исследовательский противочумный институт Сибири и Дальнего Востока».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk Research Anti-Plague Institute of Siberia and Far East.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФБУЗ «Федеральный центр гигиены и эпидемиологии».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center of Hygiene and Epidemiology.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>07</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>22</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кудрявцева Т.Ю., Попов В.П., Мокриевич А.Н., Пакскина Н.Д., Холин А.В., Мазепа А.В., Куликалова Е.С., Транквилевский Д.В., Храмов М.В., Дятлов И.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Кудрявцева Т.Ю., Попов В.П., Мокриевич А.Н., Пакскина Н.Д., Холин А.В., Мазепа А.В., Куликалова Е.С., Транквилевский Д.В., Храмов М.В., Дятлов И.А.</copyright-holder><copyright-holder xml:lang="en">Kudryavtseva T.Y., Popov V.P., Mokrievich A.N., Pakskina N.D., Kholin A.V., Mazepa A.V., Kulikalova E.S., Trankvilevsky D.V., Khramov M.V., Dyatlov I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/455">https://journal.microbe.ru/jour/article/view/455</self-uri><abstract><p>На территории Российской Федерации в 2017 г. зарегистрировано 168 случаев инфицирования человека Francisella tularensis, 80 % из которых приходилось на три федеральных округа: Северо-Западный, Северокавказский и Сибирский. Эпизоотические проявления инфекции различной степени интенсивности выявлены в 61 субъекте страны. Высокая заболеваемость туляремией в 2017 г. наблюдалась в Ставропольском крае – 49 случаев заболевания туляремией, в Республике Карелия – 40 случаев, Омской области – 20 и В Санкт-Петербурге – 12. Для оценки эпизоотической и эпидемической ситуации в каждом субъекте Российской Федерации анализировали численность мелких млекопитающих и их видовой состав, инфицированность туляремией грызунов, клещей, комаров, слепней, охотничье-промысловых животных, гнезд, погадок хищных птиц и помета хищных млекопитающих, воды открытых водоемов, количество культур возбудителя, выделенных из клинических образцов, животных, клещей и воды, а также данные по заболеваемости и вакцинации людей в регионе. Сделаны выводы о территориях, на которых наиболее вероятны эпидемиологические осложнения по туляремии в 2018 г.</p></abstract><trans-abstract xml:lang="en"><p>168 cases of human infection with Francisella tularensis were registered in the Russian Federation in 2017. 80 % of the cases are accounted for by three Federal Districts: North-Western, North-Caucasian, and Siberian ones. Epizootic manifestations of the infection of varying intensity were reported in 61 constituent entities of the Russian Federation. High morbidity rates in 2017 were observed in the Stavropol Territory – 49 tularemia cases, in the Republic of Karelia – 40, Omsk Region – 20, and Saint Petersburg – 12. To assess epizootic and epidemic situation in each constituent entity of the Federation, the numbers of small mammals and their species composition, infection rates of rodents, ticks, mosquitoes, horseflies, hunting animals, nests, regurgitates of birds of prey and excrements of carnivores, surface water bodies, agent culture numbers, isolated from clinical samples, animals, ticks and water, as well as the data on incidence and vaccination of the population in the region were analyzed. The conclusion has been drawn in regard to the territories where epidemic complications are most likely to occur in 2018.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туляремия</kwd><kwd>Francisella tularensis</kwd><kwd>природные очаги</kwd><kwd>эпидемическая ситуация</kwd><kwd>эпизоотическая ситуация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tularemia</kwd><kwd>Francisella tularensis</kwd><kwd>natural foci</kwd><kwd>epidemic situation</kwd><kwd>epizootic situation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ермаков А.В., Ковальчук И.В., Шаповалова Н.А., Сазонов А.В., Иванова Л.А., Сенатенко Ю.А., Пурмак К.А., Агапитов Д.А., Малецкая О.В. Об организации санитарно-противоэпидемических (профилактических) мероприятий в связи с активизацией природного очага туляремии в Ставропольском крае в 2017 г. В кн.: Здоровье населения и среда обитания. Ставрополь: «Параграф»; 2017. С. 19–27.</mixed-citation><mixed-citation xml:lang="en">Ermakov A.V., Koval’chuk I.V., Shapovalova N.A., Sazonov A.V., Ivanova L.A., Senatenko Yu.A., Purmak K.A., Agapitov D.A., Maletskaya O.V. [Regarding organization of sanitary-anti-epidemic (preventive) measures following activation of natural tularemia focus in the Stavropol Territory in 2017]. In: [Population Wellbeing and Environment]. Stavropol: “Paragraf”, 2017. P. 19–27.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мокриевич А.Н., Тимофеев В.С., Кудрявцева Т.Ю., Уланова Г.И., Карбышева С.Б., Миронова Р.И., Вахрамеева Г.М., Губарева Т.И., Павлов В.М., Дятлов И.А. Выделение среднеазиатского подвида туляремийного микроба на территории Алтайского края. Пробл. особо опасных инф. 2013; 1:66–9.</mixed-citation><mixed-citation xml:lang="en">Mokrievich A.N., Timofeev V.S., Kudryavtseva T.Yu., Ulanova G.I., Karbysheva S.B., Mironova R.I., Vakhrameeva G.M., Gubareva T.I., Pavlov V.M., Dyatlov I.A. [Isolation of central asian subspecies of tularemia agent in the Altai Territory]. Probl. Osobo Opasn. Infek. 2013; 1:66–9.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Challacombe J.F., Petersen J.M., Gallegos-Graves L.V., Hodge D., Pillai S., Kuske C.R. Whole-genome relationships among Francisella bacteria of diverse origins define new species and provide specific regions for detection. Appl. Environ. Microbiol. 2017; 83: e02589-16. DOI: 10.1128/AEM.02589-16.</mixed-citation><mixed-citation xml:lang="en">Challacombe J.F., Petersen J.M., Gallegos-Graves L.V., Hodge D., Pillai S., Kuske C.R. Whole-genome relationships among Francisella bacteria of diverse origins define new species and provide specific regions for detection. Appl. Environ. Microbiol. 2017; 83: e02589-16. DOI: 10.1128/AEM.02589-16.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Challacombe J.F., Pillai S., Kuske C.R. Shared features of cryptic plasmids from environmental and pathogenic Francisella species. PLoS ONE. 2017; 12(8):e0183554. DOI: 10.1371/journal.pone.0183554.</mixed-citation><mixed-citation xml:lang="en">Challacombe J.F., Pillai S., Kuske C.R. Shared features of cryptic plasmids from environmental and pathogenic Francisella species. PLoS ONE. 2017; 12(8):e0183554. DOI: 10.1371/journal.pone.0183554.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Huber B., Escudero R., Busse H.J., Seibold E., Scholz H.C., Anda P., Kampfer P., Splettstoesser W.D. Description of Francisella hispaniensis sp. nov., isolated from human blood, reclassification of Francisella novicida (Larson et al. 1955) Olsufiev et al. 1959. as Francisella tularensis subsp. novicida comb. nov. and emended description of the genus Francisella. Int. J. Syst. Evol. Microbiol. 2010; 60:1887–96. DOI: 10.1099/ijs.0.015941-0.</mixed-citation><mixed-citation xml:lang="en">Huber B., Escudero R., Busse H.J., Seibold E., Scholz H.C., Anda P., Kampfer P., Splettstoesser W.D. Description of Francisella hispaniensis sp. nov., isolated from human blood, reclassification of Francisella novicida (Larson et al. 1955) Olsufiev et al. 1959. as Francisella tularensis subsp. novicida comb. nov. and emended description of the genus Francisella. Int. J. Syst. Evol. Microbiol. 2010; 60:1887–96. DOI: 10.1099/ijs.0.015941-0.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Qu P.H., Chen S.Y., Scholz H.C., Busse H.J., Gu Q., Kдmpfer P., Foster J.T., Glaeser S.P., Chen C., Yang Z.C. 2013. Francisella guangzhouensis sp. nov., isolated from air-conditioning systems. Int. J. Syst. Evol. Microbiol. 2013; 63:3628–35. DOI: 10.1099/ijs.0.049916-0.</mixed-citation><mixed-citation xml:lang="en">Qu P.H., Chen S.Y., Scholz H.C., Busse H.J., Gu Q., Kдmpfer P., Foster J.T., Glaeser S.P., Chen C., Yang Z.C. 2013. Francisella guangzhouensis sp. nov., isolated from air-conditioning systems. Int. J. Syst. Evol. Microbiol. 2013; 63:3628–35. DOI: 10.1099/ijs.0.049916-0.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rydzewski K., Schulz T., Brzuszkiewicz E., Holland G., Lьck C., Fleischer J., Grunow R., Heuner K.. Genome sequence and phenotypic analysis of a first German Francisella sp. isolate (W121067) not belonging to the species Francisella tularensis. BMC Microbiol. 2014; 14:169. DOI: 10.1186/1471-2180-14-169.</mixed-citation><mixed-citation xml:lang="en">Rydzewski K., Schulz T., Brzuszkiewicz E., Holland G., Lьck C., Fleischer J., Grunow R., Heuner K.. Genome sequence and phenotypic analysis of a first German Francisella sp. isolate (W12-1067) not belonging to the species Francisella tularensis. BMC Microbiol. 2014; 14:169. DOI: 10.1186/1471-2180-14-169.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Timofeev V., Bakhteeva I., Titareva G., Kopylov P., Christiany D., Mokrievich A., Dyatlov I., Vergnaud G. Russian isolates enlarge the known geographic diversity of Francisella tularensis subsp. mediasiatica. PLoS ONE. 2017; 12(9):e0183714. DOI: 10.1371/journal.pone.0183714.</mixed-citation><mixed-citation xml:lang="en">Timofeev V., Bakhteeva I., Titareva G., Kopylov P., Christiany D., Mokrievich A., Dyatlov I., Vergnaud G. Russian isolates enlarge the known geographic diversity of Francisella tularensis subsp. mediasiatica. PLoS ONE. 2017; 12(9):e0183714. DOI: 10.1371/journal.pone.0183714.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
