References

microbe

Проблемы особо опасных инфекций

Problems of Particularly Dangerous Infections

0370-10692658-719X

Russian Research Anti-Plague Institute “Microbe”

10.21055/0370-1069-2010-3(105)-13-19

microbe-536

Research Article

ОБЗОРЫ

REVIEWS

Роль внеклеточного экзополисахарида в адаптации возбудителя холеры во внешней среде

The Role of Extracellular Exopolysaccharide in Cholera Agent Adaptation in the Environment

Заднова

С. П.

Zadnova

S. P.

microbe@san.ru

Смирнова

Н. И.

Smirnova

N. I.

noemail@neicon.ru

Российский научно-исследовательский противочумный институт «Микроб»РоссияRussian Research Anti-Plague Institute MicrobeRussian Federation

2010

20062010

03(105)1319

2010

Заднова С.П., Смирнова Н.И.

Zadnova S.P., Smirnova N.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.microbe.ru/jour/article/view/536

В обзоре представлены литературные данные об участии внеклеточного экзополисахарида в формировании морфологически измененных ругозных вариантов холерного вибриона, отличающихся большей устойчивостью к действию неблагоприятных факторов внешней среды, а также генетическим контролем синтеза ругозного экзополисахарида. Кроме того, приведены собственные экспериментальные данные об обнаружении в популяции Vibrio cholerae классического биовара клонов с измененной морфологией колоний (мутные) в результате продукции внеклеточного экзополисахарида и координированным изменением синтеза некоторых важных факторов патогенности (холерного токсина, растворимой гемагглютинин/протеазы, подвижности). Полученные данные позволили высказать предположение о выявлении нового механизма адаптации холерных вибрионов классического биовара при смене среды обитания.

The review presents literary data as regards the role of extracellular exopolysaccharide in formation of morphologically altered rugose variants of cholera vibrio. These variants differ by greater resistance to unfavorable factors of the environment as well as genetic control of synthesis of rugose exopolisaccharide. Besides, presented are authors` experimental data on detection of the clones with altered colony morphology (opaque) in the population of Vibrio cholerae of classical biovar. They appeared as a result of production of extracellular exopolysaccharide and coordinated alteration of synthesis of some vital pathogenicity factors (cholera toxin, soluble hemagglutinin/protease, motility). The data received suggest that revealed is new mechanism of classical cholera vibrios adaptation at a change of environmental conditions.

Vibrio choleraeругозные вариантыэкзополисахаридадаптация

Vibrio choleraerugose variantsexopolysaccharideadaptation

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The authors declare that there are no conflicts of interest present.