microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2011-1(107)-5-12microbe-577Research ArticleСтатьиСпецифическая профилактика холеры в современных условияхCholera Specific Prophylaxis in Modern ConditionsОнищенкоГ. Г.OnishchenkoG. G.noemail@neicon.ruКутыревВ. В.KutyrevV. V.microbe@san.ruЩуковскаяТ. Н.ShchukovskayaT. N.noemail@neicon.ruСмирноваН. И.SmirnovaN. I.noemail@neicon.ruНикифоровА. К.NikiforovA. K.noemail@neicon.ruЕреминС. А.EreminS. A.noemail@neicon.ruТопорковВ. П.ToporkovV. P.noemail@neicon.ruФедеральная служба по надзору в сфере защиты прав потребителей и благополучия человекаРоссияFederal Service for Surveillance in the Sphere of Consumer Rights Protection and Human WellfareRussian FederationРоссийский научно-исследовательский противочумный институт «Микроб»РоссияRussian Research Anti-Plague Institute MicrobeRussian Federation20112002201101(107)512Copyright © Онищенко Г.Г., Кутырев В.В., Щуковская Т.Н., Смирнова Н.И., Никифоров А.К., Еремин С.А., Топорков В.П., 20112011Онищенко Г.Г., Кутырев В.В., Щуковская Т.Н., Смирнова Н.И., Никифоров А.К., Еремин С.А., Топорков В.П.Onishchenko G.G., Kutyrev V.V., Shchukovskaya T.N., Smirnova N.I., Nikiforov A.K., Eremin S.A., Toporkov V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/577

Описана эпидемиологическая ситуация по холере в мире и Российской Федерации. Отмечено, что одной из причин ее осложнения является возникновение в современный период измененных вариантов Vibrio cholerae биовара eltor с повышенной вирулентностью, которые вытеснили типичные штаммы во многих странах Азии и Африки. Описаны лицензированные оральные холерные вакцины и их профилактическая эффективность. Рассмотрена стратегия ВОЗ относительно применения оральных холерных вакцин при чрезвычайных ситуациях различного характера. Представлены перспективы разработки вакцин нового поколения.

Described is cholera epidemiological situation in the world and in the Russian Federation. One of the causes of its deterioration is pointed out to be the emergence, in the modern period, of altered Vibrio cholerae eltor variants with increased virulence, which displaced typical strains in many countries of Asia and Africa. Described are licensed oral cholera vaccines and their prophylactic efficiency. Considered is the WHO strategy in regard with oral cholera vaccines application in emergencies of different character. The prospects of new generation vaccines development are presented.

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The authors declare that there are no conflicts of interest present.