microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2013-3-58-62microbe-62Research ArticleМИКРОБИОЛОГИЯMICROBIOLOGYРазличные сидерофоры обусловливают фенотип высокой патогенности иерсинийDifferent siderophores contribute to the high-pathogenicity phenotype in YersiniaРакинА.RakinA.rakin@mvp.uni-muenchen.deГазеттиД.GarzettiD.noemail@neicon.ruИнститут Макса фон ПеттенкофераРоссияMax von Pettenkofer-InstituteRussian Federation201320092013035862Copyright © Ракин А., Газетти Д., 20132013Ракин А., Газетти Д.Rakin A., Garzetti D.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/62

в бактериальную клетку. По крайней мере одна сидерофорная система, а именно, система синтеза и транспорта йерсиниобактина, отвечает за активный транспорт железа у йерсиний. Инактивация этой системы приводит к значительному снижению вирулентности у Y. pestis и Y. enterocolitica subsp. enterocolitica. Однако, йерсиниобактин присутствует далеко не у всех представителей рода йерсиний. Так, Y. pseudotuberculosis серотипов O2, O3, O4, O5, а также штаммы O1, вызывающие Дальневосточную скарлитиноподобную лихорадку, содержат альтернативную систему транспорта железа, псевдохелин, которая кодируется локусом ynp (нерибосомный синтез пептидов). Следовательно, как минимум две системы снабжения железом ассоциированы с фенотипом высокой патогенности у йерсиний, а именно, системы йерсинибактина и псевдохелина.

capture and transport in bacteria. At least one endogenous siderophore system, yersiniabactin, is known to be involved in iron acquisition in highly virulent Yersiniae . Its inactivation in Y. pestis and Y. enterocolitica subsp. enterocolitica results in significant attenuation of virulence. However, the yersiniabactin is not present in all highly virulent Yersiniae. Indeed, the large group of Y. pseudotuberculosis serotypes O2, O3, O4, O5 as well as serotype O1 Far East Scarlet like fever (FESLF) strains carry an alternative, iron acquisition system, pseudochelin, encoded by the Yersinia non-ribosomal peptide ynp locus. Thus, the yersiniabactin activity is not the only one associated with the high-pathogenicity phenotype of the human pathogenic Yersiniae .

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The authors declare that there are no conflicts of interest present.