microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2011-4(110)-18-22microbe-696Research ArticleОБЗОРЫREVIEWSСовременное состояние серодиагностики мелиоидозаCurrent State of Human Melioidosis SerodiagnosticsХраповаН. П.KhrapovaN. P.vari2@sprint-v.com.ruАлексеевВ. В.AlekseevV. V.vari2@sprint-v.com.ruВолгоградский научно-исследовательский противочумный институтРоссияVolgograd Research Anti-Plague InstituteRussian Federation20112008201104(110)1822Copyright © Храпова Н.П., Алексеев В.В., 20112011Храпова Н.П., Алексеев В.В.Khrapova N.P., Alekseev V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/696

Аналитический обзор посвящен вопросам серодиагностики мелиоидоза и перспективам ее совершенствования. Материалы цитируемых публикаций отражают значимость обнаружения специфических антител в исследуемых пробах как для ранней, так и ретроспективной диагностики мелиоидоза, а также для корректного лечения больных этой опасной инфекцией. В обзоре обобщены сведения о современных подходах к выбору метода серодиагностики в эндемичных и неэндемичных зонах распространения возбудителя инфекции, достоинствах и ограничениях наиболее широко применяемых методов обнаружения специфических антител (РНГА и ТИФМ). В последние годы внимание профильных специалистов направлено преимущественно на создание коммерчески доступных иммуноферментных тест-систем для обнаружения антител к возбудителю мелиоидоза, что обеспечит внедрение ТИФМ в лабораторную практику раннего выявления случаев заболевания людей мелиоидозом.

This analytical review is devoted to matters of human melioidosis serodiagnostics and prospects of its development and enhancement. Materials of the publications cited reflect particular significance of the specific antibody detection, for both the early and retrospective diagnostics of human melioidosis, as well as for the correct treatment of patients. Summarized are the data on modern approaches to the selection of serodiagnostics methods in the endemic and non-endemic areas, on the advantages and limitations of the most widely applicable methods for the specific antibody detection (indirect hemagglutination test and solid-phase ELISA). In recent years, development of commercially available enzyme-linked test systems for the detection of antibodies to human melioidosis agent has become an object of intense interest, as this will provide for solid-phase ELISA implementation into the laboratory practice for early detection of melioidosis cases in humans.

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The authors declare that there are no conflicts of interest present.