microbeПроблемы особо опасных инфекцийProblems of Particularly Dangerous Infections0370-10692658-719XRussian Research Anti-Plague Institute “Microbe”10.21055/0370-1069-2011-4(110)-76-79microbe-710Research ArticleБИОТЕХНОЛОГИЯBIOTECHNOLOGYКлеточные культуры в производстве гетерологичного антирабического иммуноглобулинаCell Structures in Heterologous Anti-Rabies Immunoglobulin ProductionГенераловС. В.GeneralovS. V.rusrapi@microbe.ruАбрамоваЕ. Г.AbramovaE. G.noemail@neicon.ruНикифоровА. К.NikiforovA. K.noemail@neicon.ruМатвееваЖ. В.MatveevaZh. V.noemail@neicon.ruРоссийский научно-исследовательский противочумный институт «Микроб»РоссияRussian Research Anti-Plague Institute MicrobeRussian Federation20112008201104(110)7679Copyright © Генералов С.В., Абрамова Е.Г., Никифоров А.К., Матвеева Ж.В., 20112011Генералов С.В., Абрамова Е.Г., Никифоров А.К., Матвеева Ж.В.Generalov S.V., Abramova E.G., Nikiforov A.K., Matveeva Z.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.microbe.ru/jour/article/view/710

В обзоре обозначены основные современные направления получения антирабического иммуноглобулина с улучшенными свойствами. Проанализированы результаты исследований, связанные с применением вируса бешенства, выращенного на клеточных культурах, в производстве гетерологичного антирабического иммуноглобулина.

This paper reviews basic modern trends in obtainment of anti-rabies immunoglobulin with enhanced properties. One of these trends is associated with the substitution of organ-tissue antigen by cultural antigen at the stage of producer immunization. Analyzed are the results of research connected with the use of the cell-cultures grown Rabies virus in production of heterologous anti-rabies immunoglobulin. The study testifies of applicability of the transferred Vero cell culture as a substrate for rabies antigen preparation. In addition to this, specified are the advantages of the rabies cultural antigen usage over the organ-tissue one at the stage of hyper-immune serum production.

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The authors declare that there are no conflicts of interest present.