References

microbe

Проблемы особо опасных инфекций

Problems of Particularly Dangerous Infections

0370-10692658-719X

Russian Research Anti-Plague Institute “Microbe”

10.21055/0370-1069-2013-4-60-68

microbe-80

Research Article

МИКРОБИОЛОГИЯ

MICROBIOLOGY

Стратегия вирулентности холерных вибрионов и пути ее реализации (обзор)

Cholera Vibrio Virulence Strategy and Ways of its Realization (Scientific Review)

Монахова

Е. В.

Monakhova

E. V.

plague@aaanet.ru

Ростовский-на-Дону научно-исследовательский противочумный институтРоссияRostov-on-Don Research Anti-Plague InstituteRussian Federation

2013

20122013

046068

2013

Монахова Е.В.

Monakhova E.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.microbe.ru/jour/article/view/80

В обзоре рассматриваются основные пути реализации холерными вибрионами стратегии вирулентности за счет приобретения и экспрессии генов различных токсических субстанций, а также молекулярные механизмы их взаимодействия с организмом хозяина, обмена генетической информацией, накопления и утраты детерминант факторов, неидентичных структурно, но сходных функционально. На основе анализа литературных и собственных данных предложена концепция о взаимозаменяемости факторов патогенности, которая позволяет штаммам, лишенным генов холерного токсина, восстанавливать и поддерживать патогенетический потенциал возбудителей острых диарейных заболеваний.

The basic ways of Vibrio cholerae virulence strategy realization through acquisition and expression of genes of various toxic substances are discussed. Considered are molecular mechanisms responsible for interaction between host organism and cholera vibrios, as well as for genetic information exchange, for accumulation and loss of determinants of factors, which are non-identical structurally but functionally similar. Based on the analysis of literature data and personal observations put forward is a conception of pathogenicity factor intersubstitutability allowing for restoration and maintenance of pathogenetic potential of severe diarrheal disease agents among the strains deprived of cholera toxin genes.

Vibrio choleraeтоксиныэффекторысистемы секрециифакторы колонизациибактериофагиtoxinseffectorssecretion systemscolonization factorsbacteriophages

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The authors declare that there are no conflicts of interest present.