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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2012-3-29-32</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-814</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭПИДЕМИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EPIDEMIOLOGY</subject></subj-group></article-categories><title-group><article-title>Определение влияния фактора изоляции при моделировании развития эпидемии натуральной оспы в мегаполисе</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the Effect of Isolation in the Modeling of Smallpox Epidemic Development in Megacity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Низоленко</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Nizolenko</surname><given-names>L. F.</given-names></name></name-alternatives><email xlink:type="simple">vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бачинский</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bachinsky</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научный центр вирусологии и биотехнологии «Вектор»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Centre of Virology and Biotechnology “Vector”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2012</year></pub-date><volume>0</volume><issue>3(113)</issue><fpage>29</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Низоленко Л.Ф., Бачинский А.Г., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Низоленко Л.Ф., Бачинский А.Г.</copyright-holder><copyright-holder xml:lang="en">Nizolenko L.F., Bachinsky A.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/814">https://journal.microbe.ru/jour/article/view/814</self-uri><abstract><p>В последние годы вновь признан актуальным такой фактор риска, как целенаправленное инфицирование больших групп людей возбудителями особо опасных инфекций в результате биотеррористических актов. В связи с этим важным моментом является создание математических моделей для прогнозирования последствий таких событий. С использованием разработанной в ГНЦ ВБ «Вектор» модели сравниваются сценарии развития и последствия эпидемии натуральной оспы в большом городе при наличии разного числа мест в изоляторах высокого уровня защиты для разного числа лиц, инфицированных в результате террористического акта. Результаты моделирования позволяют сделать вывод, что недостаток какого-то одного, даже столь важного ресурса, может быть частично скомпенсирован комплексом других противоэпидемических мероприятий (массовая вакцинация, выявление контактных лиц и их наблюдение). Таким образом, при планировании противоэпидемических мероприятий ресурсные ограничения должны учитываться в комплексе.</p></abstract><trans-abstract xml:lang="en"><p>Deliberate infecting of large groups of people with particularly dangerous infectious diseases agents as a result of bioterrorist attacks is still considered as an actual risk factor. Scenarios of development and aftermaths of smallpox epidemic in a large city are compared using mathematical model developed in SRC VB “Vector”. These scenarios provide that different number of people have become infected with smallpox and capacities of isolation wards with high level of protection vary. The results of the modeling suggest that lack of the one, even very important resource, can be partially compensated by implementing other counter-epidemic measures (large-scale vaccination, detection of the contacts and their monitoring). Thus when planning counter-epidemic measures one must take into consideration the resource limitations as a whole.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эпидемия</kwd><kwd>математическая модель</kwd><kwd>оспа</kwd><kwd>epidemic</kwd><kwd>mathematical model</kwd><kwd>smallpox</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бачинский А.Г. Математическая модель локальной эпидемии натуральной оспы с учетом мер противодействия и ресурсных ограничений. В кн.: 30 лет после ликвидации оспы: исследования продолжаются. Кольцово: Информ-Экспресс; 2010. С. 253–80.</mixed-citation><mixed-citation xml:lang="en">Bachinsky A.G. [Mathematical model of the local smallpox epidemic, taking into consideration countermeasures and resource limitations]. In: [30 Years after Smallpox Eradication: Investigations are in Progress]. Koltsovo; 2010. 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