<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microbe</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы особо опасных инфекций</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Particularly Dangerous Infections</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0370-1069</issn><issn pub-type="epub">2658-719X</issn><publisher><publisher-name>Russian Research Anti-Plague Institute “Microbe”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21055/0370-1069-2012-4-73-76</article-id><article-id custom-type="elpub" pub-id-type="custom">microbe-878</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИММУНОЛОГИЯ, ПРОФИЛАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>IMMUNOLOGY, PROPHYLAXIS</subject></subj-group></article-categories><title-group><article-title>Изменение эффекторной активности Т-лимфоцитов мышей, иммунизированных против туляремии, при стимуляции 
                  in vitro тулярином</article-title><trans-title-group xml:lang="en"><trans-title>Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using 
                  in vitro Stimulation by Tularin</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фирстова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Firstova</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">info@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>V. M.</given-names></name></name-alternatives><email xlink:type="simple">info@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кравченко</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kravchenko</surname><given-names>T. B.</given-names></name></name-alternatives><email xlink:type="simple">info@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зырина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zyrina</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">info@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борзилов</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Borzilov</surname><given-names>A. I.</given-names></name></name-alternatives><email xlink:type="simple">info@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дятлов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyatlov</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">info@obolensk.org</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научный центр прикладной микробиологии и биотехнологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Center for Applied Microbiology and Biotechnology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2012</year></pub-date><volume>0</volume><issue>4(114)</issue><fpage>73</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фирстова В.В., Павлов В.М., Кравченко Т.Б., Зырина Е.В., Борзилов А.И., Дятлов И.А., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Фирстова В.В., Павлов В.М., Кравченко Т.Б., Зырина Е.В., Борзилов А.И., Дятлов И.А.</copyright-holder><copyright-holder xml:lang="en">Firstova V.V., Pavlov V.M., Kravchenko T.B., Zyrina E.V., Borzilov A.I., Dyatlov I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.microbe.ru/jour/article/view/878">https://journal.microbe.ru/jour/article/view/878</self-uri><abstract><p>лимфоцитами), выделенных от мышей, иммунизированных против туляремии. Предлагается использовать тулярин в серологических исследованиях и реакциях 
                  in vitro для выявления постинфекционного или поствакцинального иммунитета к туляремии.</p></abstract><trans-abstract xml:lang="en"><p>lymphocytes) isolated from mice, immunized against tularemia. Put forward is the proposition to use tularin in serological surveys and reactions 
                  in vitro for identification of postinfectious or postvaccinal immunity to tularemia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туляремия</kwd><kwd>поствакцинальный иммунитет</kwd><kwd>CD69</kwd><kwd>ИФН-γ</kwd><kwd>ФНО-α</kwd><kwd>tularemia</kwd><kwd>postvaccinal immunity</kwd><kwd>IFN-γ</kwd><kwd>FNO-α</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мейл Д., Бростофф Дж., Рот Д.Б., Ройт А. Иммунология. М.: Логосфера; 2007. 568 с.</mixed-citation><mixed-citation xml:lang="en">Male D., Brostoff J., Roth D., Roitt A. Immunology. Elsevier; 2006. 552 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cowley S.C., Elkins K.L. Immunity to Francisella. Front. Microbiol. 2011; 2:1–26. doi:10.3389/fmicb.2011.00026.</mixed-citation><mixed-citation xml:lang="en">Cowley S.C., Elkins K.L. Immunity to Francisella. Front. Microbiol. 2011; 2:1–26. doi:10.3389/fmicb.2011.00026.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cowley S.C., Hamilton E., Frelinger J.A., Su J., Forman J., Elkins K.L. CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo. J. Exp. Med. 2005; 202(2):309–19.</mixed-citation><mixed-citation xml:lang="en">Cowley S.C., Hamilton E., Frelinger J.A., Su J., Forman J., Elkins K.L. CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo. J. Exp. Med. 2005; 202(2):309–19.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Elkins K.L., Colombini S.M., Meierovics A.I., Chu M.C., Chou A.Y., Cowley S.C. Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma. Microbes Infect. 2010.12:28–36.</mixed-citation><mixed-citation xml:lang="en">Elkins K.L., Colombini S.M., Meierovics A.I., Chu M.C., Chou A.Y., Cowley S.C. Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma. Microbes Infect. 2010.12:28–36.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Elkins K.L., Cowley S.C., Bosio C.M. Innate and adaptive immunity to Francisella. Ann. N. Y. Acad. Sci. 2007; 1105:284–324.</mixed-citation><mixed-citation xml:lang="en">Elkins K.L., Cowley S.C., Bosio C.M. Innate and adaptive immunity to Francisella. Ann. N. Y. Acad. Sci. 2007; 1105:284–324.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Katkere B., Wilson J.E., Drake J.R. Effects of interferon-γ and Francisella tularensis elicited soluble factors on macrophage antigen processing. FASEB J. 2008; 22:1068.8.</mixed-citation><mixed-citation xml:lang="en">Katkere B., Wilson J.E., Drake J.R. Effects of interferon-γ and Francisella tularensis elicited soluble factors on macrophage antigen processing. FASEB J. 2008; 22:1068.8.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wenk M.R., Fernandis A.Z. A manual for biochemistry protocols. Vol. 3. National University of Singapore. 2007. 142 p.</mixed-citation><mixed-citation xml:lang="en">Wenk M.R., Fernandis A.Z. A manual for biochemistry protocols. Vol. 3. National University of Singapore. 2007. 142 p.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wickstrum J.R., Hong K.J., Bokhari S., Reed N., McWilliams N., Horvat R.T., Parmely M.J. Coactivating signals for the hepatic lymphocyte gamma interferon response to Francisella tularensis. Infect. Immun. 2007; 75:1335–42.</mixed-citation><mixed-citation xml:lang="en">Wickstrum J.R., Hong K.J., Bokhari S., Reed N., McWilliams N., Horvat R.T., Parmely M.J. Coactivating signals for the hepatic lymphocyte gamma interferon response to Francisella tularensis. Infect. Immun. 2007; 75:1335–42.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Yazg H., Uyanik M.H. et al. [Tularemia seroprevalence in the risky population living in both rural and urban areas of Erzurum]. Mikrobiyol. Bul. 2011; 45(1):67–74.</mixed-citation><mixed-citation xml:lang="en">Yazg H., Uyanik M.H. et al. [Tularemia seroprevalence in the risky population living in both rural and urban areas of Erzurum]. Mikrobiyol. Bul. 2011; 45(1):67–74.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
