References

microbe

Проблемы особо опасных инфекций

Problems of Particularly Dangerous Infections

0370-10692658-719X

Russian Research Anti-Plague Institute “Microbe”

10.21055/0370-1069-2013-1-44-50

microbe-9

Research Article

ОБЗОРЫ И ПРОГНОЗЫ

REVIEWS AND PROGNOSES

Высокопатогенный грипп птиц A(H5N1): ситуация в 2009–2012 гг. и прогноз пандемического потенциала

Highly Pathogenic Avian Flu A(H5N1): State of Affairs in 2009–2012 and Forecast of Its Pandemic Potential

Шестопалов

А. М.

Shestopalov

A. M.

shestopalov@vector.nsc.ru

Кихтенко

Н. В.

Kikhtenko

N. V.

noemail@neicon.ru

Сергеев

А. Н.

Sergeev

A. N.

noemail@neicon.ru

Михеев

В. Н.

Mikheev

V. N.

noemail@neicon.ru

Ильичева

Т. Н.

Il’Icheva

T. N.

noemail@neicon.ru

Рыжиков

А. Б.

Ryzhikov

A. B.

noemail@neicon.ru

Государственный научный центр вирусологии и биотехнологии «Вектор»РоссияState Research Centre of Virology and Biotechnology “Vector”Russian Federation

2013

20032013

014450

2013

Шестопалов А.М., Кихтенко Н.В., Сергеев А.Н., Михеев В.Н., Ильичева Т.Н., Рыжиков А.Б.

Shestopalov A.M., Kikhtenko N.V., Sergeev A.N., Mikheev V.N., Il’Icheva T.N., Ryzhikov A.B.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.microbe.ru/jour/article/view/9

В обзоре обобщена и проанализирована современная ситуация по высокопатогенному гриппу птиц типа А подтипа H5N1 среди людей и животных за последние четыре года. Необычный рост заболеваемости, произошедший в Египте в 2009 г., а также групповые случаи заболевания людей, тесно связанных по времени и местоположению, и изменения вируса при его распространении в мире и расширении круга хозяев еще раз напоминают о том, что этот возбудитель обладает серьезным пандемическим потенциалом и требует постоянного и пристального внимания, чтобы обеспечить своевременное обнаружение происходящих эпидемиологических, клинических и вирусологических изменений.

Avian flu is an infectious viral disease in birds that still retains its positions in some parts of Asia and Africa. This review contains summarization and analysis of facts regarding the current situation on highly pathogenic avian flu A-type subtype H5N1 among people and animals for the period of the past four years. Excess incidence rate in 2009 in Egypt, as well as cluster cases of the disease in humans, closely related in time and space, virus mutations as it spreads all over the world and diversification of the host specter, testify of the fact that this agent possesses significant pandemic potential and requires continuous close attention to provide for the well-timed detection of the occurring epidemiological, clinical and virological changes.

высокопатогенный грипп птицH5N1пандемический потенциалтрансмиссивностьпопуляционный иммунитетhighly pathogenic avian fluH5N1pandemic potentialtransmissibilitypopulation immunity

References1

Львов Д.К., Щелканов М.Ю., Власов Н.А., Прилипов А.Г., Дерябин П.Г., Федякина И.Т., Галкина И.В., Забережный А.Д., Ляпина О.В., Шляпникова О.В., Киреев Д.Е., Фесенко Е.Е., Калмыков М.В., Виткова О.Н., Морозова Т.Н., Прошина Е.С., Гребенникова Т.В., Аканина Д.С., Самохвалов Е.И., Альховский С.В., Волков В.А., Семенов В.И., Гапонов В.В., Шмаков Н.И., Кушнир А.Т., Казарян А.С., Стариков Н.С., Петренко М.С., Славский А.А., Литвин К.Е., Щербакова Л.О., Фролов А.В., Манин Т.Б., Уманец О.А., Бандеев В.В., Хван А.М., Дунаев В.Г., Челедина Т.П., Абгарян С.Р., Михайлович В.М., Заседателев А.С., Любченко Е.Н., Флягин В.Н., Тихонова И.Ф., Маслов Д.В., Ананьев В.Ю., Баранов Н.И., Гореликов В.Н., Яковлев С.С., Алипер Т.И., Непоклонов Е.A., Suarez D. Первый прорыв нового для России генотипа 2.3.2 высоковирулентного вируса гриппа A/H5N1 на Дальнем Востоке. Вопр. вирусол. 2008; 5:4–8.

L’vov D.K., Shchelkanov M.Yu., Vlasov N.A., Prilipov A.G., Deryabin P.G., Fedyakina I.T., Galkina I.V., Zaberezhny A.D., Lyapina O.V., Shlyapnikova O.V., Kireev D.E., Fesenko E.E., Kalmykov M.V., Vitkova O.N., Morozova T.N., Proshina E.S., Grebennikova T.V., Akanina D.S., Samokhvalov E.I., Al’khovsky S.V., Volkov V.A., Semenov V.I., Gaponov V.V., Shmakov N.I., Kushnir A.T., Kazaryan A.S., Starikov N.S., Petrenko M.S., Slavsky A.A., Litvin K.E., Shcherbakova L.O., Frolov A.V., Manin T.B., Umanets O.A., Bandeev V.V., Khvan A.M., Dunaev V.G., Cheledina T.P., Abgaryan S.R., Mikhailovich V.M., Zasedatelev A.S., Lyubchenko E.N., Flyagin V.N., Tikhonova I.F., Maslov D.V., Anan’ev V.Yu., Baranov N.I., Gorelikov V.N., Yakovlev S.S., Aliper T.I., Nepoklonov E.A., Suarez D. [The first breakthrough of a new for the Russian Federation genotype 2.3.2 of highly virulent influenza virus – A/H5N1 – in the territory of the Far East]. Vopr. Virusol. 2008; 5:4–8.

Онищенко Г.Г., Ильичева Т.Н., Курская О.Г., Колодий К.М., Ясинская Л.М., Дурыманов А.Г., Игнашкина М.Б., Зайковская А.В., Шестопалов А.М., Дроздов И.Г. Случаи выявления антител к вирусу гриппа А/H5N1 у жителей Российской Федерации. Журн. микробиол., эпидемиол. и иммунобиол. 2010; 2:13–6.

Onishchenko G.G., Il’icheva T.N., Kurskaya O.G., Kolody K.M., Yasinskaya L.M., Durymanov A.G., Ignashkina M.B., Zaikovskaya A.V., Shestopalov A.M., Drozdov I.G. [Case detection of the antibodies to A/H5N1 influenza virus among the population of the Russian Federation]. Zh. Mikrobiol. Epidemiol. Immunobiol. 2010; 2:13–6.

Abbaszadeh Hasiri M., Nazifi S., Mohsenifard E., Ansari-Lari M. Serologic prevalence of antibodies against avian origin influenza virus in dogs referred to the Veterinary Clinic at Shiraz University. Comp. Clin. Path. 2012; 21(6):1127–30.

Abdel-Moneim A.S., Abdel-Ghany A.E., Shany S.A.S. Isolation and characterization of highly pathogenic avian influenza virus subtype H5N1 from donkeys. J. Biomed. Sci. 2010; 17(1):25–31.

Avian influenza. Fact sheet [Internet]. WHO; Update April 2011 [cited 11 Jan 2013]. Available from: http://www.who.int/midiacentre/factsheets/avian_influenza/en/

Avian influenza (68): Indonesia (Java) duck, H5N1 2.3.2.1 clade [Internet]. ProMed-mail; 12 Dec 2012 [cited 09 Jan 2013]. Archive Number 20121212.1448403. Available from: http://www.promedmail.org.

Boltz1 D.A., Douangngeun B., Phommachanh Ph., Sinthasak S., Mondry R., Obert C., Seiler P., Keating R., Suzuki Y., Hiramatsu H., Govorkova E.A., Webster R.G. Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People’s Democratic Republic. J. Gen. Virol. 2010; 91(4):949–59.

Brockwell-Staats Ch., Webster R.G., Webby R.J. Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1). Influenza Other Respi. Viruses. 2009; 3(5):207–13.

Butler D. Viral research faces clampdown. Nature. 2012; 490:456.

Cong Y., Wang G., Guan Z., Chang S., Zhang Q., Yang G., Wang W., Meng Q., Ren W., Wang C., Ding Z. Reassortant between human-like H3N2 and avian H5 subtype influenza A viruses in pigs: a potential public health risk. PLoS ONE. 2010; 5(9):e12591.

Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO, 2003–2012 [Internet]. WHO; 17 Dec 2012 [cited 09 Jan 2013]. Available from: http://www.who.int/influenza/human_animal_interface/EN_GIP_20121217CumulativeNumberH5N1cases.pdf

Dong G., Luo J., Zhang H., Wang C., Duan M., Deliberto T.J., Nolte D.L., Ji G., He H. Phylogenetic Diversity and Genotypical Complexity of H9N2 Influenza A Viruses Revealed by Genomic Sequence Analysis. PLoS ONE 2011;6(2):e17212.

FAO EMPRES. H5N1 HPAI Global overview – April–June 2012 [Internet]. 2012; Issue 32 [cited 11 Jan 2013]. 9 p. Available from: http://www.fao.org/docrep/016/ap387e/ap387e.pdf

FAO EMPRES. H5N1 HPAI Global overview – November and December 2010 [Internet]. 2010; Issue 26 [cited 09 Jan 2013]. 7 p. Available from: http://www.fao.org/docrep/013/al850e/al850e00.pdf

FAO EMPRES. H5N1 HPAI Global overview – March 2010 [Internet]. 2010; Issue 21 (cited 09 Jan 2013). 8 p. Available from: http://www.fao.org/docrep/012/ak739e/ak739e00.pdf.

Fasina F.O., Ifende V.I., Ajibade A.A. Avian influenza A(H5N1) in humans: lessons from Egypt. Euro Surveill. 2010;15(4):19473.

Harper S.A., Bradley J.S., Englund J.A., File T.M., Gravenstein S., Hayden F.G., McGeer A.J., Neuzil K.M., Pavia A.T., Tapper M.L., Uyeki T.M., Zimmerman R.K. Expert Panel of the Infectious Diseases Society of America. Seasonal influenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America. Clin. Infect. Dis. 2009; 48(8):1003–32.

Herfst S., Schrauwen E.J., Linster M., Chutinimitkul S., de Wit E., Munster V.J., Sorrell E.M., Bestebroer T.M., Burke D.F., Smith D.J., Rimmelzwaan G.F., Osterhaus A.D., Fouchier R.A. Airborne transmission of influenza A/H5N1 virus between ferrets. Science. 2012; 336(6088):1534–41.

Hien N.T., Farrar J., Horby P. Person-to-person transmission of influenza A (H5N1). Lancet. 2008; 371(9622):1392–4.

Horimoto T., Maeda K., Murakami S., Kiso M., Iwatsuki-Horimoto K., Sashika M., Ito T., Suzuki K., Yokoyama M., Kawaoka Y. Highly pathogenic avian influenza virus infection in feral raccoons, Japan. Emerg. Infect. Dis. 2011; 17(4):714–7.

Human cases of avian influenza A(H5N1) in North-West Frontier Province, Pakistan, October–November 2007. Wkly Epidemiol. Rec. 2008; 40(83):359–64.

Imai M., Watanabe T., Hatta M., Das S.C., Ozawa M., Shinya K., Zhong G., Hanson A., Katsura H., Watanabe S., Li C., Kawakami E., Yamada S., Kiso M., Suzuki Y., Maher E.A., Neumann G., Kawaoka Y. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature. 2012; 486(7403):420–8.

Katz J.M., Lim W., Bridges C.B., Rowe T., Hu-Primmer J., Lu X., Abernathy R.A., Clarke M., Conn L., Kwong H., Lee M., Au G., Ho Y.Y., Mak K.H., Cox N.J., Fukuda K. Antibody response in individuals infected with avian influenza A(H5N1) viruses and detection of anti-H5 antibody among household and social contacts. J. Infect. Dis. 1999; 180(6):1763–70.

Kayali G., Webby R.J., Ducatez M.F., El Shesheny R.A., Kandeil A.M., Govorkova E.A., Mostafa A., Ali M.A. The epidemiological and molecular aspects of influenza H5N1 viruses at the human-animal interface in Egypt. PLoS ONE. 2011; 6(3):e17730.

Li Y., Liu L., Zhang Y., Duan Z., Tian G., Zeng X., Shi J., Zhang L., Chen H. New avian influenza virus (H5N1) in wild birds, Qinghai, China. Emerg. Infect. Dis., 2011; 17(2):265–7.

Rauw F., Palya V., Van Borm S., Welby S., Tatar-Kis T., Gardin Y., Dorsey K.M., Aly M.M., Hassan M.K., Soliman M.A., Lambrecht B., van den Berg T. Further evidence of antigenic drift and protective efficacy afforded by a recombinant HVT-H5 vaccine against challenge with two antigenically divergent Egyptian clade 2.2.1 HPAI H5N1 strains. Vaccine. 2011; 29(14):2590–600.

Reid S.M., Shell W.M., Barboi G., Onita I., Turcitu M., Cioranu R., Marinova-Petkova A., Goujgoulova G., Webby R.J., Webster R.G., Russell C., Slomka M.J., Hanna A., Banks J., Alton B., Barrass L., Irvine R.M., Brown I.H. First reported incursion of highly pathogenic notifiable avian influenza A H5N1 viruses from clade 2.3.2 into European poultry. Transbound Emerg. Dis. 2011; 58(1):76–8.

Sharshov K., Silko N., Sousloparov I., Zaykovskaya A., Shestopalov A., Drozdov I. Avian influenza (H5N1) outbreak among wild birds, Russia, 2009. Emerg. Infect. Dis. 2010; 16(2):349–51.

Smith G.J., Bahl J., Vijaykrishna D., Zhang J., Poon L.L., Chen H., Webster R.G., Peiris J.S., Guan Y. Dating the emergence of pandemic influenza viruses. Proc. Natl Acad. Sci USA. 2009; 106(28):11709–12.

Summary of human infection with highly pathogenic avian influenza A (H5N1) virus reported to WHO, January 2003 – March 2009: cluster-associated cases. Wkly Epidemiol. Rec. 2010; 3(85):13–20.

Summary of human infection with highly pathogenic avian influenza A (H5N1) virus reported to WHO, January 2003 – March 2009: clusterassociated cases. Wkly Epidemiol. Rec. 2010; 3(85):13–20.

Sun Y., Qin K., Wang J., Pu J., Tang Q., Hu Y., Bi Y., Zhao X., Yang H., Shu Y., Liu J. High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses. Proc. Natl. Acad. Sci. USA 2011; 108(10):4164–9.

Thanawongnuwech R., Amonsin A., Tantilertcharoen R., Damrongwatanapokin S., Theamboonlers A., Payungporn S. Probable tiger-to-tiger transmission of avian influenza H5N1. Emerg. Infect. Dis. 2005; 11(5):699–701.

Thanawongnuwech R., Amonsin A., Tantilertcharoen R., Damrongwatanapokin S., Theamboonlers A., Payungporn S. Probable tigerto-tiger transmission of avian influenza H5N1. Emerg. Infect. Dis. 2005; 11(5):699–701.

Tiensin T., Chaitaweesub P., Songserm T., Chaisingh A., Hoonsuwan W., Buranathai C., Parakamawongsa T., Premashthira S., Amonsin A., Gilbert M., Nielen M., Stegeman A. Highly pathogenic avian influenza H5N1, Thailand, 2004. Emerg. Infect. Dis. 2005; 11(11):1664–72.

Uchida Y., Suzuki Y., Shirakura M., Kawaguchi A., Nobusawa E., Tanikawa T., Hikono H., Takemae N., Mase M., Kanehira K., Hayashi T., Tagawa Y., Tashiro M., Saito T. Genetics and infectivity of H5N1 highly pathogenic avian influenza viruses isolated from chickens and wild birds in Japan during 2010–11. Virus Res. 2012; 170(1–2):109–17.

Ungchusak K., Auewarakul P., Dowell S.F., Kitphati R., Auwanit W., Puthavathana P., Uiprasertkul M., Boonnak K., Pittayawonganon C., Cox N.J., Zaki S.R., Thawatsupha P., Chittaganpitch M., Khontong R., Simmerman J.M., Chunsutthiwat S. Probable person-to-person transmission of avian influenza A (H5N1). N. Engl. J. Med. 2005; 352(4):333–40.

Update on human cases of highly pathogenic avian influenza A(H5N1) infection: 2009. Wkly Epidemiol. Rec. 2010; 85(7):49–51.

Van Kerkhove M.D., Riley S., Lipsitch M., Guan Y., Monto A.S., Webster R.G., Zambon M., Nicoll A., Peiris J.S., Ferguson N.M. Comment on “Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis”. Science. 2012; 336(6088):1506.

Wang H., Feng Z., Shu Y., Yu H., Zhou L., Zu R., Huai Y., Dong J., Bao C., Wen L., Wang H., Yang P., Zhao W., Dong L., Zhou M., Liao Q., Yang H., Wang M., Lu X., Shi Z., Wang W., Gu L., Zhu F., Li Q., Yin W., Yang W., Li D., Uyeki T.M., Wang Y. Probable limited person-to-person transmission of highly pathogenic avian influenza A(H5N1) virus in China. Lancet, 2008; 371(9622):1427–34.

Wang T.T., Parides M.K., Palese P. Seroevidence for H5N1 influenza infections in humans: meta-analysis. Science, 2012; 335(6075):1463.

WHO case definitions for human infections with influenza A(H5N1) virus [Internet]. WHO; 26 August 2006 [cited 09 Jan 2013]. Available from: http://www.who.int/influenza/resources/ documents/case_definition2006_08_29/en/index.html.

Younan M., Poh M.K., Elassal E., Davis T., Rivailler P., Balish A.L., Simpson N., Jones J., Deyde V., Loughlin R., Perry I., Gubareva L., Elbadry M.A., Truelove S., Gaynor A.M., Mohareb E., Amin M., Cornelius C., Pimentel G., Earhart K., Naguib A., Abdelghani A.S., Refaey S., Klimov A.I., Donis R.O., Kandeel A. Microevolution of highly pathogenic avian influenza A(H5N1) viruses isolated from humans, Egypt, 2007–2011. Emerg. Infect. Dis. 2013; 19(1):43–50.

Yu H., Zhou Y.J., Li G.X., Ma J.H., Yan L.P., Wang B., Yang F.R., Huang M., Tong G.Z. Genetic diversity of H9N2 influenza viruses from pigs in China: A potential threat to human health? Veterinary Microbiology 2011; 149(1–2):254–61.

The authors declare that there are no conflicts of interest present.