References

microbe

Проблемы особо опасных инфекций

Problems of Particularly Dangerous Infections

0370-10692658-719X

Russian Research Anti-Plague Institute “Microbe”

10.21055/0370-1069-2009-3(101)-44-49

microbe-941

Research Article

ИММУНОЛОГИЯ, ПАТОГЕНЕЗ

IMMUNOLOGY, PATHOGENESIS

Особенности этиологии и иммунопатогенеза иксодовых клещевых боррелиозов

Ethiology and Immunopathogenesis Peculiarities of Ixodic Tick-Borne Borreliosis

Бикетов

С. Ф.

Bicketov

S. F.

biketov@obolensk.org

Фирстова

В. В.

Firstova

V. V.

noemail@neicon.ru

Любимов

И. И.

Lyubimov

I. I.

noemail@neicon.ru

Государственный научный центр прикладной микробиологии и биотехнологииРоссияState Research Center of Applied Microbiology and BiotechnologyRussian Federation

2009

20062009

03(101)4449

2009

Бикетов С.Ф., Фирстова В.В., Любимов И.И.

Bicketov S.F., Firstova V.V., Lyubimov I.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.microbe.ru/jour/article/view/941

В статье приводится характеристика возбудителей клещевых боррелиозов, описаны резервуарные хозяева и переносчики боррелий. Рассмотрено участие компонентов слюны клещей и поверхностных антигенов спирохет в механизмах инфицирования млекопитающих боррелиями. Изложен иммунопатогенез клещевого боррелиоза. Дана оценка существующим методам диагностики и вакцинопрофилактики клещевого боррелиоза.

The characteristics of tick-borne borreliosis agents and borrelia reservoir hosts and vectors are presented in the article. Considered is participation of ticks' saliva components and superficial spirochete antigens in the mechanisms of mammals infectioning with borrelia. Immunopathogenesis of tick-borne borreliosis is described. The available methods of diagnostics and vaccine prophylaxis of tick-borne borreliosis are evaluated.

боррелиозантигеныиммунопатогенезиксодовые клещибиоактивные молекулы слюны клещей

borreliosisantigensimmunopathogenesisixodic ticksbioactive molecules of ticks' saliva

References1

Арумова Е.А., Воронцова Т.В. Клещевой боррелиоз (болезнь Лайма) в России. Дезинфекционное дело. 2000; 2:45-7.

Манзенюк И.Н., Манзенюк О.Ю. Клещевые боррелиозы (болезнь Лайма). Кольцово, 2005. 85с.

Покровский В.И., Онищенко Г.Г., Черкасский Б.Л. Эволюция инфекционных болезней России в XX веке. М.: Медицина; 2003. 664 с.

Alekseev A.N., Arumova E.A., Vasilieva I.S. Borrelia burgdorferi sensu lato in female cement plug of Ixodes persulcatus ticks (Acari, Ixodidae). Exp. Appl. Acarol. 1995; 19:519-22.

Anguita J.A., Hedrick M.N., Fikrig E. Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiology Reviews. 2003; 27:493-504.

Babb K., El-Hage N., Miller J. C., Carroll J. A., Stevenson B. Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins. Infect. Immun. 2001; 69:4146-53.

Brooks C.S., Hefty P.S., Jolliff S.E., Akins D.R. Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals. Infect. Immun. 2003; 71:3371-83.

Burke G., Wikel S.K., Spielman A., Telford S.R., McKay K., Krause P.J. Hypersensitivity to Ticks and Lyme Disease. Risk. Emerg. Infect. Dis. 2005; 11(1):36-41.

Cartwright M.J., Martin S.E., Donta S.T. A Novel Toxin (Bb Tox 1) of Borrelia burgdorferi. 12th Annual International Conference on Lyme Borreliosis and Other Tick-borne Disorders. Chronic Lyme Disease: Basic Science and Clinical Approaches. 1999 LDF Conference Abstract, New York City, NY.

Connolly S.E., Benach J.L. The versatile roles of antibodies in borrelia infections. Nat. Rev. Microbiol. 2005; 3:411-20.

Connolly S.E., Thanassi D.G., Benach J.L. Generation of a Complement-Independent Bactericidal IgM against a Relapsing Fever Borrelia. J. Immunol. 2004; 172:1191-1197.

de la Fuente J, Kocan K.M. Strategies for development of vaccines for control of ixodid tick species. Parasite Immunol. 2006; 28:275- 83.

Fang Ting Liang , Jun Yan, Mbow L.M., Sviat S.L., Gilmore R.D., Mamula M., Fikrig E. Borrelia burgdorferi Changes Its Surface Antigenic Expression in Response to Host Immune Responses. Infect. Immun. 2004; 72(10):5759-67.

Franz J.K., Krause A. Lyme disease (Lyme borreliosis). Best Pract. Res. Clin .Rheumatol. 2003; 17(2):241-64.

Fukumoto S., Sakaguchi T., You M., Xuan X., Fujisaki K. Tick troponin I-like molecule is a potent inhibitor for angiogenesis. Microvasc. Res. 2006; 71:218-21.

Garg R., Juncadella I.J., Ramamoorthi N., Ashish, Ananthanarayanan S.K., et al. Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. J. Immunol. 2006; 177:6579-83.

Gebbia J.A., Coleman J.L., Benach J.L. Borrelia Spirochetes Upregulate Release and Activation of Matrix Metalloproteinase Gelatinase B (MMP-9) and Collagenase 1 (MMP-1) in Human Cells. Infect Immun. 2001; 69(1):456-62.

Gillespie R.D., Dolan M.C., Piesman J., Titus R.G. Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick Ixodes scapularis. J. Immunol. 2001; 166:4319-26.

Gross D.M., Forsthuber T., Tary-Lehmann M., Etling C., Ito K., Nagy Z.A., Field J.A., Steere A.C., Huber B.T. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science. 1998; 281:703-6.

Grubhoffer L., Golovchenko M., Vancovб M., Zacharovovб-Slavнčkovб K, Rudenko N, Oliver J.H. Lyme borreliosis: insights into tick-host-borrelia relations. Folia parasitologica. 2005; 52:279-94.

Hannier S., Liversidge J., Sternberg J.M., Bowman A.S. Characterization of the B-cell inhibitory protein factor in Ixodes ricinus tick saliva: a potential role in enhanced Borrelia burgdoferi transmission. Immunology. 2004; 113:40-8.

Hengge U.R., Tannapfel A., Tyring S.K., Erbel R., Arendt G., Ruzicka T. Lyme borreliosis. Lancet Infect. Dis. 2003; 3:489-500.

Hepburn N.J., Williams A.S., Nunn M.A., Chamberlain-Banoub J.C., Hamer J., et al. In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata. J. Bio.l Chem. 2007; 282:8292-99.

Hovius J.W.R., de Jong M.A.W.P., den Dunnen J., Litjens M., Fikrig E., et al. Salp15 binding to DC-SIGN inhibits dendritic cell function by impairing nucleosome remodeling and decreasing mRNA stability of pro-inflammatory cytokines. PLoS Pathog. 2008; 4:e31.

Hovius J.W.R., Levi M., Fikrig E. Salivating for Knowledge: Potential Pharmacological Agents in Tick Saliva. PLoS Med. 2008; 5(2):e43

Keane-Myers A., Nickell S.P. Role of IL-4 and IFNγ in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 1995; 155:2020-8.

Kotsyfakis M., Sa-Nunes A., Francischetti I.M., Mather T.N., Andersen J.F., et al. Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis. J. Biol. Chem. 2006; 281:26298-307.

Kuthejlova M., Kopecky J., Stepanova G., Macela A. Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages. Infect. Immun. 2001; 69:575-8.

Liang F.T., Yan J., Mbow M.L., Sviat S.L., Gilmore R.D., Mamula M., Fikrig E. Borrelia burgdorferi changes its surface antigenic expression in response to host human immune responses. Infect. Immun. 2004; 72 (10):5759-67.

Maritz-Olivier C., Stutzer C., Jongejan F., Neitz A.W., Gaspar A.R. Tick anti-hemostatics:targets for future vaccines and therapeutics. Trends Parasitol. 2007; 23:397-407.

Matyniak J. E., Reiner S.L. T helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med. 1995; 181:1251-4.

Montgomery R.R., Lusitani D., de Boisfleury Chevance A., Malawista S.E. Tick Saliva Reduces Adherence and Area of Human Neutrophils. Infect. Immun. 2004; 72 (5):2989-94.

Pal U., de Silva A.M., Montgomery R.R., Fish D., Anguita J., Anderson J.F., Lobet Y., Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J. Clin. Invest. 2000; 106:561-9.

Piesman J., Schneider B.C., Zeidner N.S. Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors. J. Clin. Microbiol. 2001; 39:4145-48.

Ramamoorthi N., Narasimhan S., Pal U., Bao F., Yang X.F., et al. The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature. 2005; 436:573-7.

Ramamoorthy R., Scholl-Meeker D. Borrelia burgdorferi proteins whose expression is similarly affected by culture temperature and pH. Infect. Immun. 2001; 69:2739-42.

Rathinavelu S., Broadwater A., de Silva A.M. Does Host Complement Kill Borrelia burgdorferi within Ticks? Infect. Immun. 2003; 71 (2):822-9.

Ribeiro, J.M.C., Weis J.J., Telford III S.R. Saliva of the tick Ixodes dammini inhibits neutrophil function. Exp. Parasitol. 1990; 70:382-8.

Schroeder H., Daix V., Gillet L., Renauld J.C., Vanderplasschen A. The paralogous salivary anti-complement proteins IRAC I and IRAC II encoded by Ixodes ricinus ticks have broad and complementary inhibitory activities against the complement of different host species. Microbes Infect. 2007; 9:247-50.

Schwan T.G., Piesman J. Vector interaction and molecular adaptation of Lyme disease and relapsing fever spirochetes associated with transmission by ticks. Emerg. Infect. Dis. 2002; 2:15-21.

Shih C.M., Pollack R.J., Telford III S.R., Spielman A. Delayed dissemination of Lyme disease spirochetes from the site of deposition in the skin of mice. J. Infect. Dis. 1992; 166:827-31.

Tyson K., Elkins C., Patterson H., Fikrig E., de Silva A. Biochemical and functional characterization of Salp20, an Ixodes scapularistick salivary protein that inhibits the complement pathway. Insect. Mo.l Biol. 2007; 16:469-79.

Urioste S., Hall L.R., Telford III S. ., Titus R.G. Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism. J. Exp. Med. 1994; 180:1077-85.

Valenzuela J.G., Charlab R., Mather T.N., Ribeiro J.M. Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis. J. Biol. Chem. 2000; 275:18717-23.

Wang G. Direct detection methods for Lyme Borrelia, including the use of quantitative assay. Vector born zoonotic dis. 2002; 2(4):223-31.

Wikel S.K. Host immunity to ticks. Annu. Rev. Entomol. 1996; 41:1-22.

Yssel H., Shanafelt M. D., Sodenberg C., Schneider R., Peltz G. Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J. Exp. Med. 1991; 174:593-601.

Yu D., Liang J., Yu H., Wu H., Xu C., et al. A tick B-cell inhibitory protein from salivary glands of the hard tick, Hyalomma asiaticum asiaticum. Biochem. Biophys. Res. Commun. 2006; 343:585-90.

Yun Xu, Bruno J.F., Luft B.J. Identification of novel tick salivary gland proteins for vaccine development. Biochem. Biophys. Res. Commun. 2005; 326:901-4.

Zeidner N.S., Nuncio M.S., Schneider B.S., Gern L., Piesman J., Brandao O., Filipe A.R. A Portuguese isolate of Borrelia lusitaniae induces disease in C3H/HeN mice. J. Med. Microbiol. 2001; 50:1055-60.

The authors declare that there are no conflicts of interest present.