Morphological Alterations in Immunocompetent Organs of Animals in Dynamics of Vaccinal Process Caused by Live Plague Vaccine with Immunomodulators
https://doi.org/10.21055/0370-1069-2008-3(97)-50-53
Abstract
Arabinoganactane isolated from Siberian larch (Larix sibirica) and its iron and cobalt nanobiocomposites were selected as immunomodulators to elucidate the possibility of intensification of specific immunity against plague. Comparative morphometric analysis of immune system organs of white mice inoculated with live plague vaccine (LPV) and its combination with immunomodulators was performed. Experimental data indicate that arabinogalactane and its nanobiocomposites used in combination with LPV increase immunocytopoetic function of immune system organs to larger extent than LPV.
About the Authors
S. A. Vityazeva
Anti-Plague Research Institute of Siberia and Far East, Irkutsk
Russian Federation
Russian Federation
T. P. Starovoitova
Anti-Plague Research Institute of Siberia and Far East, Irkutsk
Russian Federation
Russian Federation
V. I. Dubrovina
Anti-Plague Research Institute of Siberia and Far East, Irkutsk
Russian Federation
Russian Federation
S. A. Medvedeva
Institute of Chemistry of Siberian Branch of Russian Academy of Science, Irkutsk
Russian Federation
Russian Federation
L. A. Grischenko
Institute of Chemistry of Siberian Branch of Russian Academy of Science, Irkutsk
Russian Federation
Russian Federation
T. T. Shkaruba
Anti-Plague Research Institute of Siberia and Far East, Irkutsk
Russian Federation
Russian Federation
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Review
For citations:
Vityazeva S.A., Starovoitova T.P., Dubrovina V.I., Medvedeva S.A., Grischenko L.A., Shkaruba T.T. Morphological Alterations in Immunocompetent Organs of Animals in Dynamics of Vaccinal Process Caused by Live Plague Vaccine with Immunomodulators. Problems of Particularly Dangerous Infections. 2008;(3(97)):50-53. (In Russ.) https://doi.org/10.21055/0370-1069-2008-3(97)-50-53
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