F(ab’)2-Fragments of Antirabic Immunoglobulin Production Using Immobilized Pepsin
https://doi.org/10.21055/0370-1069-2008-3(97)-53-56
Abstract
Biotechnological scheme for F(ab')2-fragments of anti-rabies immunoglobulin production using immobilized pepsin was developed. Optimal ways for immobilized pepsin production were determined, conditions for fermentative hydrolysis of anti-rabies immunoglobulin were sorted out. Protective properties of F(ab')2-fragments of anti-rabies immunoglobulin produced by means of this method were assessed.
About the Authors
S. V. Generalov
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
E. G. Abramova
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
A. K. Nikiforov
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
E. M. Hramkova
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
I. A. Shepelev
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
L. V. Savitskaya
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
L. N. Minaeva
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
M. V. Galkina
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
T. A. Miheeva
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
N. N. Kochkalova
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
M. N. Kireev
Russian Anti-Plague Institute "Microbe", Saratov
Russian Federation
Russian Federation
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Review
For citations:
Generalov S.V., Abramova E.G., Nikiforov A.K., Hramkova E.M., Shepelev I.A., Savitskaya L.V., Minaeva L.N., Galkina M.V., Miheeva T.A., Kochkalova N.N., Kireev M.N. F(ab’)2-Fragments of Antirabic Immunoglobulin Production Using Immobilized Pepsin. Problems of Particularly Dangerous Infections. 2008;(3(97)):53-56. (In Russ.) https://doi.org/10.21055/0370-1069-2008-3(97)-53-56
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