Crimean-Congo Hemorrhagic Fever: Epidemiological and Epizootiological Situation in the Russian Federation in 2022, Incidence Forecast for 2023

The review presents an analysis of the epidemiological and epizootiological situation on Crimean-Congo hemorrhagic fever (CCHF) in the Russian Federation in 2022. The incidence rate of CCHF registered in 2022 (59 cases) was 1.2 times higher as compared to 2021, however, below the long-term average annual values. The mortality rate was 10.2 %, which exceeds the indicators of long-term observations (in 2012–2021 – 3.2 %). Following epizootiological survey of stationary observation points, it was found that the number of Hyalomma marginatum imago in 2022, in general, corresponded to the average long-term indicators. CCHF virus isolates circulating in Russia in 2017–2022 belonged to the genetic lines “Europe-1” (V), “Europe-2” (VI), and “Europe-3” (VII). The ratio of CCHF virus genovariants in the population on the territory of the Russian Federation in 2017–2022 didn’t change. Based on the analysis of naturalclimatic factors, the forecast for the incidence of CCHF in the Russian Federation for 2023 has been made.

1. Bente D.A., Forrester N.L., Watts D.M., McAuley A.J., Whitehouse C.A., Bray M. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res. 2013; 100(1):159–89. DOI: 10.1016/j.antiviral.2013.07.006.

2. Nasirian H. New aspects about Crimean-Congo hemorrhagic fever (CCHF) cases and associated fatality trends: A global systematic review and meta-analysis. Comp. Immunol. Microbiol. Infect. Dis. 2020; 69:101429. DOI: 10.1016/j.cimid.2020.101429.

3. De Liberato C., Frontoso R., Magliano A., Montemaggiori A., Autorino G.L., Sala M., Bosworth A., Scicluna M.T. Monitoring for the possible introduction of Crimean-Congo haemorrhagic fever virus in Italy based on tick sampling on migratory birds and serological survey of sheep flocks. Prev. Vet. Med. 2018; 149:47–52. DOI: 10.1016/j.prevetmed.2017.10.014.

4. Spengler J.R., Bergeron É., Spiropoulou C.F. Crimean-Congo hemorrhagic fever and expansion from endemic regions. Curr. Opin. Virol. 2019; 34:70–8. DOI: 10.1016/j.coviro.2018.12.002.

5. Crimean-Congo hemorrhagic fever – Europe (02): UK. [Internet]. Available from: https://promedmail.org/promedpost?place=8702222,40.

6. Crimean-Congo hemorrhagic fever – Africa (05): Cote d’Ivoire (AB) cattle, 1st report, WOAH. [Internet]. Available from: https://promedmail.org/promed-post?place=8706306,52.

7. Crimean-Congo hemorrhagic fever – Africa (08): Uganda. [Internet]. Available from: https://promedmail.org/promedpost?place=8707082,68849.

8. Crimean-Congo hemorrhagic fever – Europe (05): Spain. [Internet]. Available from: https://promedmail.org/promedpost?place=8704955,43.

9. Crimean-Congo hemorrhagic fever – Africa (03): Senegal. [Internet]. Available from: https://promedmail.org/promedpost?place=8705401,48.

10. Crimean-Congo hemorrhagic fever – Africa (07): S. Africa. [Internet]. Available from: https://promedmail.org/promedpost?place=8706547,179.

11. Crimean-Congo hemorrhagic fever – Africa (02): Mauritania (HG, TR) livestock, human, OIE. [Internet]. Available from: https://promedmail.org/promed-post?place=8701626,51.

12. Crimean-Congo hemorrhagic fever – Asia (08): Afghanistan, Kazakhstan. [Internet]. Available from: https://promedmail.org/promed-post?place=8704568,56.

13. [Three more cases of Crimean-Congo hemorrhagic fever recorded in southern Georgia]. [Internet]. Available from: https://www.newsgeorgia.ge/eshhe-tri-sluchaja-kongo-krymskoj-lihoradkizafiksirovany-na-juge-gruzii/.

14. Crimean-Congo hemorrhagic fever – Europe (03): Kazakhstan (QO, TK) Turkey. [Internet]. Available from: https://promedmail.org/promed-post?place=8703392,87.

15. Crimean-Congo hemorrhagic fever – Asia (11): Iran. [Internet]. Available from: https://promedmail.org/promedpost?place=8706762,128.

16. Crimean-Congo hemorrhagic fever – Asia (12): Afghanistan. [Internet]. Available from: https://promedmail.org/promed-post?place=8707392,137.

17. Crimean-Congo hemorrhagic fever – Asia (10): Iraq, Afghanistan. [Internet]. Available from: https://promedmail.org/promed-post/?id=20220904.8705097.

18. Maletskaya O.V., Taran T.V., Prislegina D.A., Platonov A.E., Dubyansky V.M., Volynkina A.S., Vasilenko N.F., Tokhov Yu.N., Tsapko N.V. Natural focal viral fevers in the South of the European Part of Russia. Hemorrhagic fever with renal syndrome. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2019; (4):79–84. DOI: 10.21055/0370-1069-2019-4-79-84

19. Pley C., Evans M., Lowe R., Montgomery H., Yacoub S. Digital and technological innovation in vector-borne disease surveillance to predict, detect, and control climate-driven outbreaks. Lancet Planet. Health. 2021; 5(10):e739–e745. DOI: 10.1016/S2542-5196(21)00141-8.

20. Volynkina A., Lisitskaya Y., Kolosov A., Shaposhnikova L., Pisarenko S., Dedkov V., Dolgova A., Platonov A., Kulichenko A. Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in Russia. PLoS One. 2022; 17(5):e0266177. DOI: 10.1371/journal.pone.0266177.

21. Lukashev A.N., Deviatkin A.A. Phylodynamics of Crimean Congo hemorrhagic fever virus in South Russia. Infect. Genet. Evol. 2018; 59:23–7. DOI: 10.1016/j.meegid.2018.01.016.

22. Lukashev A.N., Klimentov A.S., Smirnova S.E., Dzagurova T.K., Drexler J.F., Gmyl A.P. Phylogeography of Crimean Congo hemorrhagic fever virus. PLoS One. 2016; 11(11):e0166744. DOI: 10.1371/journal.pone.0166744.

23. Kulichenko A.N., Maletskaya O.V., Vasilenko N.F., Beyer A.P., Sannikova I.V., Pasechnikov V.D., Koval’chuk I.V., Ermakov A.V., Butaev T.M., Smirnova S.E., Karan’ L.S., Maleev V.V., Platonov A.E. Crimean hemorrhagic fever in Eurasia in the 21st century: epidemiological aspects. Epidemiologiya i Infektsionnye Bolezni. Aktual’nye Voprosy [Epidemiology and Infectious Diseases. Topical Issues]. 2012; 3:42–53.

24. Ahmeti S., Berisha L., Halili B., Ahmeti F., von Possel R., Thomé-Bolduan C., Michel A., Priesnitz S., Reisinger E.C., Günther S., Krüger A., Sherifi K., Jakupi X., Hemmer C.J., Emmerich P. Crimean-Congo hemorrhagic fever, Kosovo, 2013–2016. Emerg. Infect. Dis. 2019; 25(2):321–4. DOI: 10.3201/eid2502.171999.

25. Papa A., Markatou F., Maltezou H.C., Papadopoulou E., Terzi E., Ventouri S., Pervanidou D., Tsiodras S., Maltezos E. Crimean-Congo haemorrhagic fever in a Greek worker returning from Bulgaria, June 2018. Euro Surveill. 2018; 23(35):1800432. DOI: 10.2807/1560-7917.ES.2018.23.35.1800432.

26. Papa A., Pappa S., Panayotova E., Papadopoulou E., Christova I. Molecular epidemiology of Crimean-Congo hemorrhagic fever in Bulgaria – An update. J. Med. Virol. 2016; 88(5):769–73. DOI: 10.1002/jmv.24400.

27. Sherifi K., Cadar D., Muji S., Robaj A., Ahmeti S., Jakupi X., Emmerich P., Krüger A. Crimean-Congo hemorrhagic fever virus clades V and VI (Europe 1 and 2) in ticks in Kosovo, 2012. PLoS Negl. Trop. Dis. 2014; 8(9):e3168. DOI: 10.1371/journal.pntd.0003168.