Analysis of Epidemiological and Epizootiological Situation on Q Fever in the Russian Federation over the Period of 2013–2024 and Short-Term Forecast of Morbidity for 2025

The review presents an assessment of the epidemiological and epizootiological situation regarding Q fever in the Russian Federation for the period from 2013 to 2024, excluding the data for 2020 and 2021 due to anti-epidemic measures aimed at COVID-19, as well as covers current aspects of combating this infection. An evaluation of the epidemic potential of Q fever in Russia and other countries, where an increase in activity of infection foci has been observed, is made. Ranking of the Q fever-affected regions in the Russian Federation has been carried out based on morbidity rates, with a very high level of epidemic risk noted for Astrakhan Region (average long-term morbidity rate is 9.31 per 100 thousand population). An analysis of Q fever cases in Russia during 2024 has revealed 286 registered cases (0.20 per 100 thousand population), where Stavropol Territory contributed significantly to the total number of Coxiella infections – 138 cases (4.78) – and Astrakhan Region added another 127 cases (13.39), accounting for 92.7 % of all recorded cases. Q fever registration within the territory of the Russian Federation occurred from March through December 2024 inclusively, reaching its peak in June–July. The results of monitoring Q fever in the Stavropol, Altai, and Primorsk Territories as well as Astrakhan, Rostov, and Omsk Regions are provided in the paper. Antibodies of class G against Coxiella burnetii were detected in blood serum samples taken across all surveyed areas. In the Astrakhan Region, markers (DNA) of C. burnetii were found in sheep wool and skin samples, feeding stuff, milk, soil, and bedding used by farm animals. Overall, DNA/antigen of C. burnetii was identified in 5.3 % of Ixodidae tick samples collected across six regions.

1. Rudakov N.V., Zelikman S.Yu., Shpynov S.N. [Q Fever: Ecological and Epidemiological Aspects: Information Letter]. Omsk: Publishing center “KAN”; 2021. 28 p.

2. Shpynov S.N., Rudakov N.V., Zelikman S.Yu. [Analysis of Q fever incidence in the Russian Federation between 1957 and 2019]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2021; (3):134–40. DOI: 10.21055/0370-1069-2021-3-141-146.

3. Christodoulou M., Malli F., Tsaras K., Billinis C., Papagiannis D. A narrative review of Q fever in Europe. Cureus. 2023; 15(4):e38031. DOI: 10.7759/cureus.38031.

4. Dijkstra F., van der Hoek W., Wijers N., Schimmer B., Rietveld A., Wijkmans C.J., Vellema P., Schneeberger P.M. The 2007–2010 Q fever epidemic in the Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunol. Med. Microbiol. 2012; 64(1):3–12. DOI: 10.1111/j.1574-695X.2011.00876.x.

5. Whelan J., Schimmer B., Schneeberger P., Meekelenkamp J., Ijff A., van der Hoek W., Robert-Du Ry van Beest Holle M. Q fever among culling workers, the Netherlands, 2009–2010. Emerg. Infect. Dis. 2011; 17(9):1719–23. DOI: 10.3201/eid1709.110051.

6. Fedorova N.I. [Epidemiology and Prevention of Q-Rickettsiosis]. М.: “Meditsina”; 1968. 251 p.

7. Yakovlev E.A., Borisevich S.V., Popova A.Yu., Ezhlova E.B., Demina Yu.V. [Morbidity rates of Q fever in the Russian Federation and European countries: realities and problems]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2015; (4):49–54. DOI: 10.21055/0370-1069-2015-4-49-54.

8. Dedok L.A., Marushchak L.V., Polupan I.M., Mezhensky A.O. [Serological monitoring of Q fever in farm animals in Ukraine]. Veterinarnaya Biotekhnologiya [Veterinary Biotechnology]. 2020; (37):31–6. DOI: 10.31073/vet_biotech37-03.

9. Perfil’eva Yu.V., Mashzhan A.S., Zhigailov A.V., Ostapchuk E.O., Maltseva E.R., Najzabaeva D.A., Berdygulova Zh.A., Bisenbaj A.O., Skiba Yu.A., Dmitrovsky A.M., Mamadaliev S.M. [Prevalence of Q fever in the southern region of Kazakhstan]. Vestnik Kazakhskok Natsional’nogo Universiteta. Seriya Ekologicheskaya [Bulletin of the Kazakh National University. Ecological Series]. 2022; (4):99–110. DOI: 10.26577/EJE.2022.v73.i4.010.

10. Rustamova S.I., Safi N.V., Yusifova K.Yu. [Seasonal prevalence of Coxiella burnetii in the farms of the Azerbaijan Republic in 2022–2023]. Biologiya v Sel’skom Hozyajstve [Biology in Agriculture]. 2023; (4):27–30.

11. Savilov E.D., Astaf’ev V.A., Zhdanova S.N., Zarudnev E.A. [Epidemiological Analysis. Methods of Statistical Processing of the Material]. Novosibirsk: “Nauka-Tsentr”; 2011. 156 p.

12. Rudakov N.V., Pen’evskaya N.A., Kumpan L.V., Blokh A.I., Shpynov S.N., Trankvilevsky D.V., Shtrek S.V. [Epidemiological si¬ tuation on tick-borne spotted fever group rickettsioses in the Russian Federation in 2012–2021, prognosis for 2022–2026]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2022; (1):54–63. DOI: 10.21055/0370-1069-2022-1-54-63.

13. Kolpakov S.L., Yakovlev A.A. [Regarding methodolo¬ gy for assessing the epidemiological situation]. Epidemiologiya i Infektsionnye Bolezni [Epidemiology and Infectious Diseases]. 2015; 20(4):34–9.