MORPHOLOGICAL-FUNCTIONAL CHARACTERISTICS OF IMMUNE COMPETENT ORGANS OF BALB/C MICE IN CASE OF VACCINATION WITH YERSINIA PESTIS NIIEG STRAIN AGAINST THE BACKGROUND OF IMMUNE MODULATION
https://doi.org/10.21055/0370-1069-2017-2-58-62
Abstract
Objective of the study is to specify the character and dynamics of morpho-functional changes in the organs of peripheral immune system of BALB/c mice in case of immunization with vaccine Yersinia pestis EV NIIEG strain against the background of immune modulation. Materials and methods. Applying a combination of histological, histo-chemical, immune histo-chemical methods, and morphometric analysis, defined has been the targeting of immunological processes in peripheral lymphoid organs of BALB/c mice. Results and conclusions. Revealed has been stimulating effect of polyoxidonium in concomitant use of Yersinia pestis EV NIIEG, on the processes of cell proliferation in T-zones of lymphoid organs, on activation of T- and B-lymphocyte sub-population in them by reference to the increment in the amount of specifically stained with CD25 marker cells and nuclei of lymphocytes with high argyrophil granule content, indirectly characterizing the functional state of nuclei apparatus, as well as on response intensification of neuroendocrine environment of lymphoid structures. Based on the results of complex morphological analysis, specified have been the peculiarities of morphofunctional changes in immune competent organs of biomodels, being indicative of polyoxidonium potential to increase the effectiveness of vaccination against plague.
About the Authors
S. A. Bugorkova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
46, Universitetskaya St., Saratov, 410005
Russian Federation
46, Universitetskaya St., Saratov, 410005
A. F. Kurylina
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
46, Universitetskaya St., Saratov, 410005
Russian Federation
46, Universitetskaya St., Saratov, 410005
T. N. Shchukovskaya
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
46, Universitetskaya St., Saratov, 410005
Russian Federation
46, Universitetskaya St., Saratov, 410005
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Review
For citations:
Bugorkova S.A., Kurylina A.F., Shchukovskaya T.N. MORPHOLOGICAL-FUNCTIONAL CHARACTERISTICS OF IMMUNE COMPETENT ORGANS OF BALB/C MICE IN CASE OF VACCINATION WITH YERSINIA PESTIS NIIEG STRAIN AGAINST THE BACKGROUND OF IMMUNE MODULATION. Problems of Particularly Dangerous Infections. 2017;(2):58-62. (In Russ.) https://doi.org/10.21055/0370-1069-2017-2-58-62
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