Immunobiological Properties of Francisella tularensis Antigen Complexes
https://doi.org/10.21055/0370-1069-2011-3(109)-46-49
Abstract
Carried out are the studies of preparations of Francisella tularensis antigen complexes, obtained from the producer strains of different subspecies (holarctica, nearctica, mediasiatica, novicida). It is discovered that the outer-membrane (OM) antigen complex is a common antigen of Francisella tularensis regardless of its sub-specific origin. Antigen complexes isolated from strains of holarctica, nearctica, and mediasiatica subspecies have similar chemical and subunit composition, and immunobiological properties. Peculiarities of composition of F. tularensis subsp. novicida OM-antigen complex lead to the decrease of its immunogenicity and protective capability in comparison with analogous antigens of other subspecies.
Keywords
Francisella tularensis,
subspecies of tularemia agent,
antigens,
immunogenicity,
protective capability
616.981.455:576.809.7
About the Authors
E. M. Kuznetsova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
O. A. Volokh
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
E. A. Smol`kova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
T. N. Shchukovskaya
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
I. A. Shepelev
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
N. G. Avdeeva
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
A. L. Kravtsov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
A. K. Nikiforov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
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Review
For citations:
Kuznetsova E.M., Volokh O.A., Smol`kova E.A., Shchukovskaya T.N., Shepelev I.A., Avdeeva N.G., Kravtsov A.L., Nikiforov A.K. Immunobiological Properties of Francisella tularensis Antigen Complexes. Problems of Particularly Dangerous Infections. 2011;(3(109)):46-49. (In Russ.) https://doi.org/10.21055/0370-1069-2011-3(109)-46-49
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