Several Biochemical Differences between the Production Strains, Cholera Chemical Vaccine Producers
https://doi.org/10.21055/0370-1069-2011-3(109)-78-80
Abstract
Detected are several differences in biochemical properties of V. cholerae 569 B Inaba and V. cholerae M41 Ogawa productive strains. The differences are in the protein content in culture liquid, in the dynamics of enzyme activity in the process of reactor strain growth, and in the protease, phospholipase A2 and C activity. Demonstrated is the diverse resistance of enzymes of both of the strains to formaldehyde detoxification effect. Identified is the difference in enzyme activity of fractions, which are obtained by means of isoelectric precipitation of culture liquid proteins within the limits of pH 3,5-4,4.
About the Authors
I. A. Kuz`michenko
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
O. V. Gromova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
M. N. Kireev
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
N. I. Belyakova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
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Review
For citations:
Kuz`michenko I.A., Gromova O.V., Kireev M.N., Belyakova N.I. Several Biochemical Differences between the Production Strains, Cholera Chemical Vaccine Producers. Problems of Particularly Dangerous Infections. 2011;(3(109)):78-80. (In Russ.) https://doi.org/10.21055/0370-1069-2011-3(109)-78-80
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