Interaction between Bacillus anthracis and Pattern-Recognizing Receptors of Innate and Adaptive Immunity
https://doi.org/10.21055/0370-1069-2011-4(110)-12-17
Abstract
According to modern views, protection of an organism from different pathogens is achieved through functioning of the two chains of immune system - innate and acquired ones. Initially, receptors of non-specific immunity, including Toll-like receptors, identify conservative pathogen-associated molecular structures. The subsequent activation of signaling pathways leads to rapid neutralization and elimination of foreign agent. Concurrently, initiation of the adaptive immunity, and realization of pro-inflammatory reactions' cascade take place. The review summarizes literature data concerning peculiarities of innate and adaptive types of immunity in case of interaction between macro-organism and Bacillus anthracis. Protective antigen, lipoprotein, cell wall components, anthrolysine O, CpG DNA sequence and others are the potential ligands of Toll-like receptors in B. anthracis. Demonstrated are the results of experiments that bear evidence of the fact, that synthetic agonists of Toll-like receptors influence realization of B. anthracis cytotoxicity and course of infection in laboratory animals. Modificators of Toll-like receptor functions can be used as immunostimulators for designing of effective means of anti-infectious protection. Innate and adaptive components of the immunity, having their own unique mechanisms of the specific B. anthracis identification, interact with each other, strengthen and complement each other.
About the Authors
P. Yu. Popova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
N. I. Mikshis
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
T. N. Shchukovskaya
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
Yu. A. Popov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
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Review
For citations:
Popova P.Yu., Mikshis N.I., Shchukovskaya T.N., Popov Yu.A. Interaction between Bacillus anthracis and Pattern-Recognizing Receptors of Innate and Adaptive Immunity. Problems of Particularly Dangerous Infections. 2011;(4(110)):12-17. (In Russ.) https://doi.org/10.21055/0370-1069-2011-4(110)-12-17
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