Study of Protective Properties of Gentamicin in Liposome-Entrapped and Free Forms in Case of Aerogenic Melioidosis Infection
https://doi.org/10.21055/0370-1069-2011-4(110)-90-91
Abstract
Presented are data on investigation of protective properties of free and liposome-entrapped forms of gentamicin against aerogenic infection caused by melioidosis agent. Comparative study identified that immobilization of gentamicin into liposomes increased substantially the ED50 of the preparation. This, probably, can be related to higher sorbtion of liposomal preparation by parenchymal organs including lungs.
About the Authors
S. N. Tikhonov
Volgograd Research Anti-Plague Institute
Russian Federation
Russian Federation
K. A. Rotov
Volgograd Research Anti-Plague Institute
Russian Federation
Russian Federation
V. V. Alekseev
Volgograd Research Anti-Plague Institute
Russian Federation
Russian Federation
E. A. Snatenkov
Volgograd Research Anti-Plague Institute
Russian Federation
Russian Federation
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Review
For citations:
Tikhonov S.N., Rotov K.A., Alekseev V.V., Snatenkov E.A. Study of Protective Properties of Gentamicin in Liposome-Entrapped and Free Forms in Case of Aerogenic Melioidosis Infection. Problems of Particularly Dangerous Infections. 2011;(4(110)):90-91. (In Russ.) https://doi.org/10.21055/0370-1069-2011-4(110)-90-91
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