Experimental Evaluation of Application of Cross-Flow Ultrafiltarion Method for O Antigen Concentrating in Cholera Chemical Bivalent Vaccine Production
https://doi.org/10.21055/0370-1069-2011-2(108)-83-85
Abstract
Demonstrated is possibility to apply cross-flow ultrafiltration method for O antigen of Vibrio cholerae M-41 Ogawa concentrating from germ-free centrifugate. Technological process of concentrating was optimized. Worked out were the regimes of conservation and cleaning of the ultrafiltration device. The prospects of cross-flow ultrafiltration method introduction in technology of cholera chemical bivalent vaccine production were determined.
About the Authors
A. V. Komissarov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
S. A. Eremin
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
Yu. A. Aleshina
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
Yu. G. Vasin
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
O. D. Klokova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
N. I. Beliakova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
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Review
For citations:
Komissarov A.V., Eremin S.A., Aleshina Yu.A., Vasin Yu.G., Klokova O.D., Beliakova N.I. Experimental Evaluation of Application of Cross-Flow Ultrafiltarion Method for O Antigen Concentrating in Cholera Chemical Bivalent Vaccine Production. Problems of Particularly Dangerous Infections. 2011;(2(108)):83-85. (In Russ.) https://doi.org/10.21055/0370-1069-2011-2(108)-83-85
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