Examination of Processes of Cultivation of V. cholerae strains - Producers of Protective Antigens of Cholera Bivalent Chemical Vaccine in Tablets - in the Engineered Bioreactor
https://doi.org/10.21055/0370-1069-2012-2(112)-85-88
Abstract
Studied is the kinetics of major antigen accumulation at growing of Vibrio cholerae M-41 Ogawa and 569 B Inaba strains in industrial and engineered reactors. Demonstrated is the possibility to obtain conditional native protective antigens in the engineered bioreactor. Shown is the identity of physiological and morphological properties of industrial Vibrio cholerae strains during their submerged cultivation in industrial and engineered bioreactors. Cholera bivalent chemical vaccine obtained using engineered bioreactor possesses quality indices meeting the requirements of normative documents and equal to those of preparation received by traditional approach.
Keywords
615.371/.372:663.15:66.081.63
About the Authors
A. K. Nikiforov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
A. V. Komissarov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
A. Yu. Ul'yanov
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
S. A. Eremin
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
O. A. Volokh
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
N. I. Belyakova
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
Yu. A. Aleshina
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
Yu. G. Vasin
Russian Research Anti-Plague Institute Microbe
Russian Federation
Russian Federation
References
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3. Nikiforov A.K., Vasin Yu.G., Shcherbakov D.A., Ul’yanov A.Yu., Stroganov V.V., Eremin S.A. [Fermentation unit for cultivation of microorgan- isms]. RF patent № 86184.
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Review
For citations:
Nikiforov A.K., Komissarov A.V., Ul'yanov A.Yu., Eremin S.A., Volokh O.A., Belyakova N.I., Aleshina Yu.A., Vasin Yu.G. Examination of Processes of Cultivation of V. cholerae strains - Producers of Protective Antigens of Cholera Bivalent Chemical Vaccine in Tablets - in the Engineered Bioreactor. Problems of Particularly Dangerous Infections. 2012;(2(112)):85-88. (In Russ.) https://doi.org/10.21055/0370-1069-2012-2(112)-85-88
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