Preview

Problems of Particularly Dangerous Infections

Advanced search

Variability of the aspA Genes in Yersinia pestis Strains of the Main and Non-Main Subspecies

https://doi.org/10.21055/0370-1069-2009-1(99)-52-54

Abstract

Demonstrated was variability of the aspA gene nucleotide sequence in Yersinia pestis strains of the main and non-main subspecies isolated in the Russian Federation and neighboring countries. Strains of altaica and hissarica subspecies, just as Yersinia pseudotuberculosis, possess valine in position 363 of the AspA protein. Strains of caucasica and ulegeica subspecies carry serine in this position, while strains of the main subspecies carry leucine. The aspA gene variability is thought to be applicable for genotyping of plague agent strains.

About the Authors

G. A. Eroshenko
Russian Anti-Plague Research Institute “Microbe", Saratov
Russian Federation

410005, Saratov, Universitetskaya St., 46



G. N. Odinokov
Russian Anti-Plague Research Institute “Microbe", Saratov
Russian Federation
410005, Saratov, Universitetskaya St., 46


Ya. M. Krasnov
Russian Anti-Plague Research Institute “Microbe", Saratov
Russian Federation
410005, Saratov, Universitetskaya St., 46


N. P. Gooseva
Russian Anti-Plague Research Institute “Microbe", Saratov
Russian Federation
410005, Saratov, Universitetskaya St., 46


V. V. Kutyrev
Russian Anti-Plague Research Institute “Microbe", Saratov
Russian Federation
410005, Saratov, Universitetskaya St., 46


References

1. Ерошенко Г.А., Видяева Н.А., Одиноков Г.Н. и др.. Структурно-функциональный анализ гена araC у штаммов различного происхождения. Мол. генетика, микробиол. и вирусол. 2009; (2):(в печати).

2. Куклева Л.М., Ерошенко Г.А., Куклев В.Е. и др. Исследование вариабельности нуклеотидной последовательности генов rha локуса у штаммов Yersinia pestis основного и неосновных подвидов. Мол. генетика, микробиол. и вирусол. 2008; 2:23-7.

3. Bearden S.W., Sexton C., Pare J. et al. Attenuated enzootic (pestiodes) isolates of Yersinia pestis express active aspartase. Microbiology. 2009; 155:198-209.

4. Brubaker R.R. Intermediary metabolism Na+, the low calcium response and acute disease. In: Perry R.D., editor. The genus Yersinia: from genomics to function. New York: Springer; 2007. P. 116-29

5. Sanger F., Nicklen L., Coulson A. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 1977; 74:5463-7.

6. Viola R.E., Yerman L., Fowler J.M. et al. A missense mutation causes aspartase deficiency in Yersinia pestis. Microbiology. 2008; 154:1271-80.


Review

For citations:


Eroshenko G.A., Odinokov G.N., Krasnov Ya.M., Gooseva N.P., Kutyrev V.V. Variability of the aspA Genes in Yersinia pestis Strains of the Main and Non-Main Subspecies. Problems of Particularly Dangerous Infections. 2009;(1(99)):52-54. (In Russ.) https://doi.org/10.21055/0370-1069-2009-1(99)-52-54

Views: 544


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0370-1069 (Print)
ISSN 2658-719X (Online)