Structural and Functional Analysis of nap Operon Genes in Yersinia pestis Strains of Different Subspecies
https://doi.org/10.21055/0370-1069-2008-4(98)-40-42
Abstract
Carried out was structural and functional analysis of nap genes coding for a significant diagnostic feature - nitrate reduction in main and non-main subspecies of Yersinia pestis. The presence of a single nucleotide substitution (A for T in position 631) in gene napA was determined to be the reason for the lack of nitrate reduction in part of the main subspecies strains. Other mutation - single nucleotide substitution G for A in position 1021 of napA is not the reason for absence of this diagnostic feature in non-main subspecies and biovar microtus as this substitution is present in denitrifying and nondenitrifying strains.
About the Authors
G. N. Odinokov
Russian Anti-Plague Institute “Microbe", Saratov
Russian Federation
Russian Federation
G. A. Eroshenko
Russian Anti-Plague Institute “Microbe", Saratov
Russian Federation
Russian Federation
N. A. Vidyaeva
Russian Anti-Plague Institute “Microbe", Saratov
Russian Federation
Russian Federation
Ja. M. Krasnov
Russian Anti-Plague Institute “Microbe", Saratov
Russian Federation
Russian Federation
N. P. Gouseva
Russian Anti-Plague Institute “Microbe", Saratov
Russian Federation
Russian Federation
V. V. Kutyrev
Russian Anti-Plague Institute “Microbe", Saratov
Russian Federation
Russian Federation
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Review
For citations:
Odinokov G.N., Eroshenko G.A., Vidyaeva N.A., Krasnov J.M., Gouseva N.P., Kutyrev V.V. Structural and Functional Analysis of nap Operon Genes in Yersinia pestis Strains of Different Subspecies. Problems of Particularly Dangerous Infections. 2008;(4(98)):40-42. (In Russ.) https://doi.org/10.21055/0370-1069-2008-4(98)-40-42
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