Phenotypic Peculiarities of Pathogenic Burkholderia Mutants Resistant to Fluoroquinolones and Cephalosporins
https://doi.org/10.21055/0370-1069-2008-2(96)-32-35
Abstract
Examined were phenotypic peculiarities of mutants of Burkholderia phylogenetically-related pathogenic species (B. pseudomallei, B. mallei, B. cepacia) resistant to fluoroquinolones and cephalosporins. It was shown that strains with PfxR (OfxR), CfzR markers acquire high multi-drug resistance to antibiotics of different classes. Strain resistance changes under blocking influence of verapamil - inhibitor of calcium membrane channels. Mutant strains differ in production of extracellular enzymes (proteases, lecithinase, lipase) and virulence.
About the Authors
E. V. Kalinkina
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
N. P. Ageeva
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
O. A. Merinova
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
D. A. Loboiko
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
D. V. Viktorov
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
L. K. Merinova
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
References
1. Пушкарева В.И., Величко В.В., Каминская А.А. Burkholderia cepaica в разных экологических условиях: численность и изменчивость бактериальной популяции. Журн. микробиол., эпидемиол. и иммунобиол. 2005; 3: 39-44.
2. Шагинян И.А., Чернуха М.Ю. Бактерии комплекса Burkholderia cepaica: особенности диагностики, организации генома и метаболизма. Мол. генет., микробиол., вирусол. 2003; 2: 7-11.
3. Coenye Т., Vandamme P. Environ. Microbiol. 2003; 5:719-29.
4. Difco manual. Dehydrated culture media and reagents ror microbiology. Detroit Michigan; 1985. 1155 p.
5. Gibson R.L., Burns J.L., Ramsey B.W. Am. J. Respir. Crit. Care Med. 2003; 168:918-51.
6. Moore R.A., DeShaserD., Reckseidler S. Antimicrob. Agents Chemother. 1999; 43:465-70.
7. Moore R.A., Woods D.E. In: International Congress on Melioidosis Proceeding. Bangkok; 1998. р. 157.
8. Yabuuchi E., Kosako Y., Oyaizu H., et al. Microbiol. Immunol. 1992; 36:1251-75.
Review
For citations:
Kalinkina E.V., Ageeva N.P., Merinova O.A., Loboiko D.A., Viktorov D.V., Merinova L.K. Phenotypic Peculiarities of Pathogenic Burkholderia Mutants Resistant to Fluoroquinolones and Cephalosporins. Problems of Particularly Dangerous Infections. 2008;(2(96)):32-35. (In Russ.) https://doi.org/10.21055/0370-1069-2008-2(96)-32-35
Views:
536
Email this article 