Phenotypic Peculiarities of Pathogenic Burkholderia Mutants Resistant to Fluoroquinolones and Cephalosporins
https://doi.org/10.21055/0370-1069-2008-2(96)-32-35
Abstract
Examined were phenotypic peculiarities of mutants of Burkholderia phylogenetically-related pathogenic species (B. pseudomallei, B. mallei, B. cepacia) resistant to fluoroquinolones and cephalosporins. It was shown that strains with PfxR (OfxR), CfzR markers acquire high multi-drug resistance to antibiotics of different classes. Strain resistance changes under blocking influence of verapamil - inhibitor of calcium membrane channels. Mutant strains differ in production of extracellular enzymes (proteases, lecithinase, lipase) and virulence.
About the Authors
E. V. Kalinkina
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
N. P. Ageeva
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
O. A. Merinova
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
D. A. Loboiko
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
D. V. Viktorov
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
L. K. Merinova
Volgograd Anti-Plague Research Institute
Russian Federation
Russian Federation
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Review
For citations:
Kalinkina E.V., Ageeva N.P., Merinova O.A., Loboiko D.A., Viktorov D.V., Merinova L.K. Phenotypic Peculiarities of Pathogenic Burkholderia Mutants Resistant to Fluoroquinolones and Cephalosporins. Problems of Particularly Dangerous Infections. 2008;(2(96)):32-35. (In Russ.) https://doi.org/10.21055/0370-1069-2008-2(96)-32-35
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