Molecular Epidemiology of Pathogenic Hantaviruses in the Far East of Russia, 2015-2018
https://doi.org/10.21055/0370-1069-2019-4-102-108
Abstract
Human pathogenic hantaviruses, belonging to the family Hantaviridae, genus Orthohantavirus, are disseminated worldwide and cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. In the Far East of Russia Hantaan (HTNV), Amur (AMRV) and Seoul (SEOV) viruses are etiologic agent of HFRS, while the human pathogenic potential of other seven hantaviruses, circulating in this region, has not been researched adequately yet. Objective of the study was genetic identification of hantaviruses, associated with HFRS in the Far East of Russia during 2015-2018. Materials and methods. Blood samples of 64 HFRS patients from Jewish Autonomous Region, Khabarovsk and Primorsky Territories were analyzed for hantavirus RNA using reverse transcription polymerase chain reaction. Results and discussion. A total of 19 viral RNA isolates from HFRS patients were genetically typed. Etiologic agents of HFRS were three pathogenic hantaviruses: HTNV (13 isolates), AMRV (3 isolates), SEOV (3 isolates). Three genetic lineages were identified among HTNV, two lineages among AMRV One genetic variant of SEOV virus was identified among HFRS patients, which was more close to the strains from South-Eastern Asia than to those from the neighboring countries.
About the Authors
L. N. Yashina
State Scientific Centre of Virology and Biotechnology “Vector”
Russian Federation
Russian Federation
Lyudmila N. Yashina.
Kol’tsovo, Novosibirsk Region, 630559.
N. A. Smetannikova
State Scientific Centre of Virology and Biotechnology “Vector”
Russian Federation
Russian Federation
Kol’tsovo, Novosibirsk Region, 630559.
G. G. Kompanets
G.P. Somov Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
1, Selskaya St., Vladivostok.
N. I. Zdanovskaya
Khabarovsk Plague Control Station
Russian Federation
Russian Federation
7, Sanytarny Lany, Khabarovsk, 680031.
L. I. Ivanov
Khabarovsk Plague Control Station
Russian Federation
Russian Federation
7, Sanytarny Lany, Khabarovsk, 680031.
References
1. Jonsson C.B., Figueiredo L.T.M., Vapalahti O. A global perspective on hantavirus ecology, epidemiology, and disease. Clin. Microbiol. Rev. 2010; 23(2):412-41. DOI: 10.1128/CMR.00062-09.
2. Tkachenko E.A., Bernshtein A.D., Dzagurova T.K., Bashkirtsev V.N., Sedova N.S., Malkin A.E., Gorbachkova E.A., Balakirev A.E., Drozdov S.G., Sikora I.V., Shchukina I.A., Savel’ev S.I., Bogatova I.S., Trankvilevsky D.V., Chubirko M.I., Torubarova E.S., Nurgaleeva R.G., Minin G.D., Zagidullin I.M., Ivanova A.A., Zhukov V.I., Morozov S.G., Haibulina S.F., Morzunov S.P. [Comparative analysis of epidemic outbreaks of hemorrhagic fever with renal syndrome, caused by Puumula, and Dobrava/Belgrade viruses]. Epidemiologiya i Vaktsinoprofilaktika [Epidemiology and Vaccinal Prevention]. 2005; 4:28-34.
3. Klempa B., Tkachenko E.A., Dzagurova T.K., Yunicheva Y.V., Morozov V.G., Okulova N.M., Slyusarenko G.P, Smirnov A., Kruger D.H. Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerg. Inf Dis. 2008; 14(4):617-25. DOI: 10.3201/eid1404.071310.
4. Slonova R.A., Kushnareva T.V., Kompanets G.G., Maksema I.G., Simonova T.L., Simonov S.B. [Hantavirus infection in the Primorsky Territory - epidemiological situation in the foci, where various serotype circulate]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 2006; S3:74-7.
5. Yashina L.N., Patrushev N.A., Ivanov L.I., Slonova R.A., Mishin V, Kompanez G.G., Zdanovskaya N.I., Kuzina I.I., Safronov P.F., Chizhikov V.E., Schmaljohn С., Netesov S.V. Genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the Far East of Russia. Virus Res. 2000; 70(1-2):31-44. DOI: 10.1016/s0168-1702(00)00203-3.
6. Yashina L., Mishin V, Zdanovskaya N., Schmaljohn C., Ivanov L. A newly discovered variant of a hantavirus in Apodemus peninsulae, Far Eastern Russia. Emerg. Infect. Dis. 2001; 7:912-913.
7. Kariwa H., Yoshimatsu K., Arikawa J. Hantavirus infection in East Asia. Comp. Immunol. Microbiol. Infect. Dis. 2007; 30(5-6): 341-56. DOI: 10.1016/j.cimid.2007.05.011.
8. Zhang Y.Z., Zou Y, Yao L.S., Hu G.W., Du Z.S., Jin L.Z., Liu YY., Wang H.X., Chen X., Chen H.X., Fu Z.F. Isolation and characterization of hantaviruses carried by Apodemus peninsulae in Jilin, China. J. Gen. Virol. 2007; 88(Pt4):1295-331. DOI: 10.1099/vir.0.82534-0.
9. Kariwa H., Yoshikawa K., Tanikawa Y, Seto T., Sanada T., Saasa N., Ivanov L.I., Slonova R., Zakharycheva T.A., Nakamura I., Yoshimatsu K., Arikawa J., Yoshii K., Takashima I. Isolation and characterization of hantaviruses in Far East Russia and etiology of hemorrhagic fever with renal syndrome in the region. Am. J. Trop. Med. Hyg. 2012; 86(3):545-53. DOI: 10.4269/ajtmh.2012.11-029f
10. Maes P., Adkins S., Alkhovsky S.V, Avsic-Zupanc T., Ballinger M.J., Bente D.A., Beer M., Bergeron E., Blair C.D., Briese T., Buchmeier M.J., Burt F.J., Calisher C.H., Charrel R.N., Choi I.R., Clegg J.C.S., Juan Carlos de la Torre, Xavier de Lamballerie, DeRisi J.L., Digiaro M., Drebot M., Ebihara H., Elbeaino T., Ergunay K., Fulhorst C.F., Garrison A.R., Gao G.F., Gonzalez J.-P.J., Groschup M.H., Gunther S., Haenni A.-L., Hall R.A., Hewson R., Hughes H.R., Jain R.K., Jonson M.G., Junglen S., Klempa B., Klingslrom J., Kormelink R., Lambert A.J., S.A. Langevin, Lukashevich I.S., Marklewitz M., Giovanni P. Martelli, Mielke-Ehret N., Mirazimi A., Muhlbach H.-P., Naidu R., Nunes M.R.T., Palacios G., Papa A., Paw^ska J.T., Peters C.J., Plyusnin A.,. Radoshitzky S.R, Resende R.O., Romanowski V, Sall A.A., Salvato M.S., Sasaya T., Schmaljohn C., Shi X., Shirako Y., Simmonds P., Sironi M., Song J.-W., Spengler J.R., Stenglein M.D., Tesh R.B., Turina M., Wei T., Whitfield A.E., Yeh S.-D., Zerbini F.M., Zhang Y-Z., Zhou X., Kuhn J.H. Taxonomy of the order Bunyavirales: Second update 2018. Arch. Virol. 2019; 164(3):927-41. DOI: 10.1007/s00705-018-04127-3.
11. Zou Y, Hu J., Wang Z.X., Wang D.M., Li M.H., Ren G.D., Duan Z.X., Fu Z.F., Plyusnin A., Zhang YZ. Molecular diversity and phylogeny of Hantaan virus in Guizhou, China: evidence for Guizhou as a radiation center of the present Hantaan virus. J. Gen. Virol. 2008; 89(Pt8):1987-97. DOI: 10.1099/vir.0.2008/000497-0.
12. Slonova R.A., Yashina L.N., Kompanets G.G., Mishin VA. Antigen and genetic characteristics of Seoul virus strains - agent of hemorrhagic fever with renal syndrome. Voprosy Virusologii [Problems ofVirology]. 2003; 48(3):10-4.
13. Horling h Chizhikov V, Lundkvist A., Jonsson M., Ivanov A., Dekonenko A., Niklasson B., Dzagurova T Peters C.J., Tkachenko E., Nichol S. Khabarovsk virus: a phylogenetically and serologically distinct hantavirus isolated from Microtus fortis trapped in far-east Russia. J. Gen. Virol. 1996; 77(Pt):687-94. DOI: 10.1099/0022-1317-77-4-687.
14. Yashina L.N., Ivanov L.I., Slonova R.A., Kompanets G.G., Gutorov V.V., Kushnareva T.V., Vysochina N.P., Abramov S.A., Dupal T.A., Pukhovskaya N.M., Zdanovskaya N.I. [Hantaviruses circulating in voles Microtus fortis and Microtus maximowiczii], Tikhookeansky Meditsinskii Zhurnal [Pacific Medical Journal]. 2008; 2:47-9.
15. Zou Y., Wang J.B., Gaowa H.S., Yao L.S., Hu G.W., Li M.H., Chen H.X., Plyusnin A., Shao R., Zhang YZ. Isolation and genetic characterization of hantaviruses carried by Microtus voles in China. J. Med. Virol. 2008; 80(4):680-8. DOI: 10.1002/jmv.21119.
16. Ivanov L.I., Zdanovskaya N.I., Tkachenko E.A., Rezapkin G.V., Ryl’ceva E.V., Gaponova L.K., Vorob’eva R.N., Volkov VI. [Areal and natural reservoirs of the virus of hemorrhagic fever with renal syndrome in the Far East of Russia]. Voprosy Virusologii [Problems ofVirology]. 1989; 34(5):595-8.
17. Kariwa H., Yashimatsu K., Sawabe J., Yokota E., Arikawa J., Takashima I., Fukushima H., Lundkvist A., Shubin F.N., Isachkova L.M., Slonova R.A., Leonova G.N., Hashimoto N. Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia. Virus Res. 1999; 59(2):219-28. DOI: 10.1016/s0168-1702-(98)00141-5.
18. Yashina L.N., Slonova R.A., Oleinik O.V, Kuzina I.I., Kushnareva T.V, Kompanets G.G., Simonov S.B., Simonova T.L., Morzunov S.P., Netesov S.V [New genetic variant of Puumala virus in Primorye and its natural carrier , red-grey vole Clethrionomys rufocanus]. Voprosy Virusologii [Problems of Virology]. 2004;
19. Zhang YZ. Discovery of hantaviruses in bats and insectivores and the evolution of the genus Hantavirus. Virus Res. 2014; 187:15-21.
20. Yashina L.N., Kartashov M.Yu., Wang W., Li K., Zdanovskaya N.I., Ivanov L.I., Zhang YZ. Co-circulation of distinct shrew-borne hantaviruses in the far east of Russia. Virus Res. 2019; 272:197717. DOI: 10.1016/j.virusres.2019.197717.
21. Klempa B., Fichet-Calvet E., Lecompte E., Auste B., Aniskin V, Meisel H., Denys C., Koivogui L., Jan ter Meulen, Kruger D.H. Hantavirus in African wood mouse, Guinea. Emerg. Infect. Dis. 2006; 12:838-40. DOI: 10/3201/eid1205.051487.
Review
For citations:
Yashina L.N., Smetannikova N.A., Kompanets G.G., Zdanovskaya N.I., Ivanov L.I. Molecular Epidemiology of Pathogenic Hantaviruses in the Far East of Russia, 2015-2018. Problems of Particularly Dangerous Infections. 2019;(4):102-108. (In Russ.) https://doi.org/10.21055/0370-1069-2019-4-102-108
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