Epidemiological Situation on Tick-Borne Rickettsioses in the Russian Federation in 2010–2019 and Prognosis for 2020

Objective of the study was to analyze the incidence of Siberian tick-borne typhus (STBT) in the Russian Federation between 2010 and 2019, Astrakhan spotted fever (ASF) and Mediterranean fever (MF) since official registration, and forecast the development of the epidemic process for endemic rickettsioses for 2020. Materials and methods. The analysis of the incidence of STBT, ASF and MF in the Russian Federation over the period of 2010–2019, 2013–2019 and 2014–2019, respectively, in relation to the results of zoological-entomological monitoring. Results and discussion. The average long-term incidence rate of STBT for 2010–2019 in the Russian Federation on the whole was 1.1 ⁰ /₀₀₀₀ (DI₉₅ 1.05÷1.08) without trends towards change. The maximum relative incidence of STBT is typical for the Siberian Federal District (SFD) where the average long-term incidence rate for 2010–2019 amounted to 6.28 per 100 thousand of the population. In the second place is the Far Eastern Federal District (FEFD) – 5.17 ⁰ /₀₀₀₀, in third – the Ural Federal District (UFD) – 0.1 ⁰ /₀₀₀₀. When assessing the 10‑year dynamics of the relative incidence of STBT, we have revealed a significant tendency to increase in the FEFD, a tendency to stabilize in the SFD and a significant downward trend – in the UFD. A reliable increasing trend in STBT incidence was detected in the Altai Republic and in the Khabarovsk Territory. Major decline in STBT incidence was observed in the Trans-Baikal territory, Krasnoyarsk territory, Kurgan Region and the Republic of Khakassia. There is a marked tendency to increase in the incidence of MF in the Republic of Crimea. In the Astrakhan Region and the Republic of Kalmykia, there is an expressed tendency towards the reduction in the ASF morbidity rates.

1. Rudakov N. V., Shpynov S. N., Samoylenko I. E., Obert A. S. [Tick-borne rickettsioses and rickettsiae of the tick spotted fever group in Russia]. Omsk; 2011. P. 231.

2. Zdrodovsky P. F., Golinevich E. M. [The Study of the Rickettsiae and Rickettsioses]. 3rd ed. Moscow: “Meditsina”; 1972. 496 p.

3. Fournier P.E., Zhu Y., Yu X., Raoult D. Proposal to cre- ate subspecies of Rickettsia sibirica and an emended description of Rickettsia sibirica. Ann. NY Acad. Sci. 2006; 1078:597–606. DOI: 10.1196/annals.1374.120.

4. Sentausa E., Karkouri E.K., Robert C., Raoult D., Fournier P.E. Sequence and annotation of Rickettsia sibirica sibirica genome. J. Bacteriol. 2012; 194(9):2377. DOI: 10.1128/JB.00150-12.

5. Zhu Y., Fournier P.E., Eremeeva M., Raoult D. Proposal to create subspecies of Rickettsia conorii based on multi-locus se- quence typing and an emended description of Rickettsia conorii. BMC Microbiology. 2005; 5:11. DOI: 10.1186/1471-2180-5-11.

6. Tarasevich I. V. [Astrakhan Spotted Fever]. Moscow: “Meditsina”; 2002. 171 p..

7. Berdlinskaya N. R., Galimzyanov Kh. M., Mirekina E. V. [Clinical and epidemiological aspects of Astrakhan rickettsia fever depending on the severity of the disease]. [Pest Management]. 2019; (1):22–7. DOI: 10.25732/PM.2019.109.1.004.

8. Pen’kovskaya N.A. [Epidemiological features of Marseilles fever in Crimea at the current stage]. Krymsky Terapevtichesky Zhurnal [Crimean Therapeutic Journal]. 2014; 1:140–6..

9. Gorovenko M.V., Karimov I.Z. [Relevant vector-borne natural-focal infections of Crimea]. Infektsiya i Immunitet [Russian Journal of Infection and Immunity]. 2016; 6(1):25–32. DOI: 10.15789/2220-7619-2016-1-25-32.

10. Gafarova M.T., Verbenets E.A., Achkasova, T.A., Shmoylov D.K., Midikari A.S. [Epidemiology and clinical features of Marseilles fever in Crimea]. Infektsyonnye Bolezni: Novosti, Mnenya, Obuchenie [Infectious Diseases: News, Opinions, Training]. 2017; (2):61–6. DOI: 10.24411/2305-3496-2017-00035

11. Jia N., Jiang J. F., Huo Q.B., Jiang B.G., Cao W.C. Rickettsia sibirica subspecies sibirica BJ-90 as a cause of human disease. N. Engl. J. Med. 2013; 369(12):1176–8. DOI: 10.1056/ NEJMc1303625.

12. Liu W., Li H., Lu Q.B., Cui N., Yang Z.D., Hu J.G., Fan Y.D., Guo C.T., Li X.K., Wang Y.W., Liu K., Zhang X.A., Yuan L., Zhao P.Y., Qin S.L., Cao W.C. Candidatus Rickettsia tarasevichiae infection in Eastern Central China: a case series. Ann. Intern. Med. 2016; 164(10):641–8. DOI: 10.7326/M15-2572.

13. Igolkina Y., Krasnova E., Rar V., Savelieva M., Epikhina T., Tikunov A., Khokhlova N., Provorova V., Tikunova N. Detection of causative agents of tick-borne rickettsioses in Western Siberia, Russia: identification of Rickettsia raoultii and Rickettsia sibirica DNA in clinical samples. Clin. Microbiol. Infect. 2018; 24(2):199. e9-199.e12. DOI: 10.1016/j.cmi.2017.06.003.

14. Rudakov N., Samoylenko I., Shtrek S., Igolkina Y., Rar V., Zhirakovskaya E., Tkachev S., Kostrykina T., Blokhina I., Lentz P., Tikunova N. A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and «Candidatus Rickettsia tara- sevichiae» infection in Russia. Ticks Tick Borne Dis. 10(6):101278. DOI: 10.1016/j.ttbdis.2019.101278.

15. Lang T.A. [How to describe statistics in medicine. Annotated guide for authors, editors, and reviewers]. Moscow: Practical medi- cine; 2011. 480 p.

16. Rudakov N.V., Shpynov S.N., Trankvilevsky D.V., Packina N.D., Savelyev D.A., Samoilenko I.E., Reshetnikova T.A., Kumpan L.V., Pen`evskaya N.A. [Features of the epidemic situation on Siberian tick-borne typhus and other tick-borne rickettsioses in the Russian Federation, prognosis for 2019]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2019; (1):14–22. DOI: 10.21055/0370-1069-2019-1-89-97.

17. Korenberg E.I. [Ways to improve epidemiological surveil- lance of natural focal infections]. Epidemiologia i Vaktsynoprofilaktika [Epidemiology and Vaccinal Prevention]. 2016; 15(6):18–29. DOI: 10.31631/2073-3046-2016-15-6-18-29.

18. Trankvilevsky D.V. [About infection of small mammals with pathogens of zoonoses in the Russian Federation]. Zdorovie Naseleniya i Sreda Obitaniya [Public Health and Life Environment]. 2016; 10:53–6.

19. Trankvilevsky D.V., Tsarenko V.A., Zhukov V.I. [Current state of epizootiological monitoring of natural foci of infections in the Russian Federation]. Meditsynskaya Parazitologia i Parazitarnye Bolezni [Medical Parasitology and Parasitic Diseases]. 2016; 2:19–24.