The Role of Disinsection and Deratization in the Framework of Non-Specific Prophylaxis of Diseases among the Population in Natural Plague Foci in the Territory of the CIS Countries

Natural foci of plague – a particularly dangerous transmissible zoonotic disease – are widely spread across the world, including in the territory of Russia and a number of neighboring countries in Central Asia. Between 2000 and 2019, 28339 cases of plague were registered in 21 states around the world; lethality rates reached 8 %. Active plague manifestations are associated with the increase in the abundance of carriers and vectors of the disease, which increases the risk of human infection. Prophylactic measures against plague are aimed at prevention and eradication of epidemic foci; they incorporate a whole complex (system) of activities. Disinsection and deratization remain the most radical of them. Control of the numbers of carriers and vectors of plague involves decrement up to the levels at which epizooties will not develop, they are suppressed and liquidated. Currently in the Russian Federation and CIS countries, the focus is on the field and community disinsection when planning and performing exterminatory interventions. The decrease in the numbers of fleas – carriers and vectors of plague microbe – results in disruption of epizootic process and, consequently, in provision of epidemiological welfare as regards this dangerous disease. Insecticide treatments in natural biotopes are carried out using powder-like or aerosolized products, the class of pyrethroids, organophosphorous compounds and phenylpyrazoles by means of advanced equipment: knapsack dusters, power operated air blowers, and foggers. Within the boundaries of residential areas wet disinsection is performed with the help of spraying devices. Field deratization is allowed upon epidemiological grounds only, in localized territories of epizooties, within the boundaries of the settlements of plague infected carriers. Zinc phosphide- or anticoagulant-based bait products are used as rodenticides. Therewith, the eradication of valuable animal species, rare species of small mammals and endemic species is prohibited. Community deratization is always accompanied by the community disinsection. When planning and carrying out insecticide and rodenticide treatments the priority is given to the safety of handling the chemical preparations, to the exclusion of the negative effect on target animal species.

1. Onishchenko G.G., Kutyrev V.V., editors. [Natural Plague Foci in the Territory of Caucasus, Caspian Sea Region, Central Asia and Siberia]. Moscow: “Meditsina”; 2004, 192 p.

2. Bramanti B., Stenseth N.C., Walle L., Lei X. Plague: A disease which changed the path of human civilization. Yersinia pestis: Retrospective and Perspective. Dordrecht: Springer; 2016. Р. 1–26.

3. Popova A.Yu., Kutyrev V.V., editors. [Ensuring Epidemiological Well-Being in Natural Plague Foci in the Territory of the CIS Countries and Mongolia under Modern Conditions]. Izhevsk: “Print” LLC; 2018. 336 p. DOI: 10.23648/PRNT.2445.

4. Josko D. Yersinia pestis: still a plague in the 21st century. Clin. Lab. Sci. 2004; 17(1):25–9.

5. Gage K.L., Kosoy M.Y. Natural History of Plague Perspectives from More than a Century of Research. Annual Review of Entomology. 2005; 50:505–28.

6. Lloyd-Smith J.O., George D., Pepin K.M., Pitzer V.E., Pulliam J.R., Dobson A.P., Hudson P.J., Grenfell B.T. Epidemic dynamics at the human-animal interface. Science. 2009; 326(5958):1362–7.

7. Riehm J.M., Vergnaud G., Kiefer D., Damdindorj T., Dashdavaa O., Khurelsukh T., Zöller L., Wölfel R., Le Flèche P., Scholz H.C. Yersinia pestis Lineages in Mongolia. PLoS One. 2012; 7(2):e30624. DOI: 10.1371/journal.pone.0030624.

8. Bertherat E. Plague around the world, 2010–2015. Weekly epidemiological record. 2016; 91(8):89–104.

9. Barnes A.M. Survellance and control of bubonic plague in the United States. Proc. Symp. Zool. Soc. London. 1982; 50:237–68.

10. Wang Zuwang, Zhang Zhibin. Theory and Practice of Rodent Pest Management. Science Press Beijing; 1996. 378 p.

11. Sapozhnikov V.I., Serzhan O.S., Bezverkhny A.V., Kovaleva G.G., Kopbaev E.Sh. [Plague in the Balkhash-Alakol Depression]. Almaty: “Rakhat” JSC; 2001. 140 p.

12. Kutyrev V.V., Popova A.Yu., editors. [Cadastre of Epidemic and Epizootic Manifestations of Plague in the Territory of the Russian Federation and Former Soviet Union (1876–2016)]. Saratov: “Amirit” LLC; 2016. 248 p.

13. Verzhutsky D.B. [Activation of natural plague foci in Central Asia: groundless fears or a real threat]. Priroda Vnutrenney Azii [Nature of Inner Asia]. 2018; 1(6):7–17. DOI: 10.18101/2542-0623-2018-1-7-18.

14. Popov N.V., Karnaukhov I.G., Pakskina N.D., Eroshenko G.A., Kuznetsov A.A., Matrosov A.N., Porshakov A.M., Kouklev E.V., Ivanova A.V., Korzun V.M., Kosilko S.A., Zenkevich E.S., Popov V.P., Lopatin A.A., Ayazbaev T.Z., Balakhonov S.V., Kutyrev V.V. [Analysis of the Current Epidemiological Situation in Natural Plague Foci around the World. Enhancement of the Effectiveness of Epidemiological Surveillance in Natural Plague Foci of the Russian Federation and Forecast of their Epizootic Activity for 2019]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2019; (1):81–8. DOI: 10.21055/0370-1069-2019-1-81-88.

15. Balakhonov S.V., Verzhutsky D.B., editors. [Tuva Natural Plague Focus]. Irkutsk: Publishing House of Irkutsk State University; 2019. 286 p.

16. Ibragimov E.Sh., Usenbaev N.T. [Dynamics of epizootic activity of mezzo-foci of the Sarydzhas Autonomous plague focus]. Vestnik Kyrgyzskoy Gosudrastvennoy Meditsinskoy Akademii im. Akhunbayeva [Bulletin of the Kyrgyz State Medical Academy Named after Akhunbayev]. Bishkek; 2014. P. 37–40.

17. Abdikarimov S.T., Ibragimov E.S., Egembergenov C.E. Current Epizootic Condition of Natural Plague Foci in Kyrgyz Republic and Measures Aimed at Provision of Epidemiological Welfare as regards Plague. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2018; (2):45–8. DOI: 10.21055/0370-1069-2018-2-45-48.

18. Balakhonov S.V., Korzun V.M., Kosilko S.A., Mikhailov E.P., Shchuchinov L.V., Mishchenko A.I., Zarubin I V., Rozhdestvensky E.N., Denisov A.V. [Topical issues of ensuring epidemiological well-being of the population as regards plague in the Altai Republic]. Epidemiologiya i Vaktsinoprofilaktika [Epidemiology and Vaccinal Prevention]. 2016; 4(89):42–8. DOI: 10.31631/2037-3046-2016-15-4-42-48.

19. Popova A.Yu., Balakhonov S.V., Shchuchinov L.V., Matrosov A.N., Mikhailov E.P., Mishchenko A.I., Denisov A.V., Shefer V.V., Shestakov V.A., Rozhdestvensky E.N., Chipanin E.V., Korzun V.M., Kosilko S.A., Innokent’eva T.I., Yarygina M.B., Sbitneva S.V., Tagyzova S.L., Arkhipov G.S., Shcherbakova S.A., Toporkov V.P., Kouklev E.V., Razdorsky A.S., Kuznetsov A.A., Sludsky A.A., Popov N.V., Ermakov N.M., Kutyrev V.V. [Organization of anti-epidemic and preventive measures as regards plague in the territory of the Kosh-Agach District of the Altai Republic and assessment of their activity]. Infektsionnye Bolezni [Infectious Diseases]. 2018; 16(4):5–15. DOI: 10.20953/1729-9225-2018-4-5-15.

20. Popova A.Yu., Kutyrev V.V., Balakhonov S.V., Ezhlova E.B., Demina Yu.V., Pakskina N.D., Shchuchinov L.V., Popov N.V., Kosilko S.A., Dubrovina V.I., Korzun V.M., Mikhailov E.P., Mishchenko A.I., Denisov A.V., Rozhdestvensky E.N., Bugorkova S.A., Eroshenko G.A., Krasnov Y.M., Toporkov V.P., Sludsky A.A., Razdorsky A.S., Matrosov A.N., Porshakov A.M., Lopatin A.A., Shcherbakova S.A. Coordination of Measures of Plague Control Institutions, Aimed at Rehabilitation and Sanitation of Gorno-Altai High-Mountain Natural Plague Focus in 2016 Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections].2016; (4):5–10. DOI: 10.21055/0370-1069-2016-4-5-10

21. Altybaev K.I., Kulnazarov B.K. [Current status of red marmot populations (Marmota caudata) in the Alai natural plague focus]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2004; 1(9):54–8.

22. Balakhonov S.V., Korzun V.M., editors. [Gorno-Altai Natural Plague Focus: Retrospective Analysis, Epizootiological Monitoring, Current Status]. Novosibirsk: “Nauka-Tsentr”; 2014. 272 p.

23. Ad”yaasuren Z., Tserennorov D., Myagmar Zh., Ganhuyag C., Otgonbayar D., Bayar Ts., Verzhutsky D.B., Ganbold D., Balakhonov S.V. [The current situation in the natural plague foci of Mongolia]. Dal’nevostochny Zhurnal Infektsionnoj Patologii [Far Eastern Journal of Infectious Pathology]. 2014; 25:22–5.

24. Matrosov A.N., Kuznetsov A.A., Knyazeva T.V. [Ecological aspects of rodent population control in natural plague foci in the territory of the Russian Federation]. Еkologiya [Ecology]. 2011; 4:266–71.

25. Ibragimov E.S. Non-Specific Prophylaxis in the Tien Shan High-Mountain Natural Plague Focus: Past and Present. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 2015; (4):18–21. DOI: 10.21055/0370-1069-2015-4-18-21.

26. Ibragimov E.Sh., Bakhvalov V.F., Vorotnikov I.A., Shvartz A.I. [Deep disinsection of groundhog burrows and DDT migration to environmental objects]. In: [Natural Health and Prevention of Zoonoses]. Saratov; 1987. P. 91–3.

27. Nikitin A.Ya., Kardash A.I. [Possibility of using certain pyrethroids for the prevention of plague in natural foci of Siberia of gopher type]. Meditsinskaya Parazitologiya i Parazitarnye Bolezni [Medical Parasitology and Parasitic Diseases]. 2009; 4:42–4.

28. Burdelov L.A., Zhumadilova Z. B., Meka-Mechenko V.G., Sazhnev Yu.S., Akimbaev B.A., Sailaubekuly R., Abdukarimov N., Belyaev A.I., Nauruzbaev E.O., Sapozhnikov V.I., Ageev V.S., Pakuleva E.V. [Results of three-year field tests of aerosolization of great gerbil burrows (Rhombomys opimus) in ultra-small volumes]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2014; 1(29):14–21.

29. Nikitin A.Ya., Vershinin E.A., Nechaeva L.K. [Statistical techniques for short-term forecasting of flea population fluctuations in natural plague centers]. Karantinnyye i Zoonoznyye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2001; 3:192–5.

30. Burdelov L.A., Dernovaya V.F. [The state of anti-plague activities in the Republic of Kazakhstan at the present stage and prospects for its improvement]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2003; 1(7):3–16.

31. Dubyansky V.M. [Concept of using GIS technologies and remote sensing in plague surveillance]. Vrach i Informatsionnye Tekhnologii [Physician and IT]. 2012; 3:42–6.

32. Dubyansky V.M., Kulichenko A.N., Semenko O.V., Maletskaya O.V., Mezentsev V.M. [Improving epidemiological surveillance of infectious diseases using geo-information systems]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 2014; 1:85–91.

33. Kuznetsov A.A., Matrosov A.N., Porshakov A.M., Sludsky A.A., Kovalevskaya A.A., Toporkov V.P. [Principles of cartographic differentiation and epidemiological zoning of natural plague foci for assessing and minimizing public health risks]. Analiz Riska Zdoprov’yu [Health Risk Analysis]. 2018; 4:96–104. DOI: 10.21668/health.risk/2018.4.11.

34. Verzhutsky D.B., Nikitin A.Ya., Kovaleva N.I., Galatsevich N.F., Chumakova N.A., Tkachenko S.V., Chumakov A.V. [The main results of disinsection in the valley of the Sagly river (Tuva natural plague focus)]. Dal’nevostochny Zhurnal Infektsionnoj Patologii [Far Eastern Journal of Infectious Pathology]. 2014; 25:18–22.

35. Grazhdanov A.K., Matrosov A.N. [History and current state of field prophylaxis of plague in the West of Kazakhstan]. Pest-Management [Pest Management]. 2015; 2:5–10.

36. Protopopyan M.G. [The problem of sanitation of natural plague foci]. In: [Prophylaxis of Natural Focal Infections]. Stavropol; 1983. P. 415–7.

37. Rudenchik Yu.V., Soldatkin I.S. [History of the fight against the natural focality of plague. Domestic experience]. In: [Entertaining Essays on the Activities and Figures of the Anti-Plague System of Russia and the Soviet Union]. Moscow: “Informatika”; 1995. P. 60–86.

38. Dyatlov A.I. [Prospects for fighting the plague in its natural foci]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 2001; 6:64–6.

39. Shevchenko V.L., Dubyansky M.A. [Concerning the cases of poisoning of birds with grain baits with zinc phosphide]. Еkologiya [Ecology]. 1988; 1:85–7.

40. Shilova S.A. [Population Ecology as the Basis for Controlling the Numbers of Small Mammals]. Moscow: “Nauka”; 1993. 201 p.

41. Protopopyan M.G. [Field pest control in natural plague foci of the USSR]. In: [Epidemiology, Epizootiology and Prevention of Particularly Dangerous Infections]. Saratov; 1986. P. 55–68.

42. Survillo A.V., Korneev G.A., Volkov V.M., Nuzhny A.I., Kochkareva A.V., Zubov V.V. [Testing of new insecticidal preparations in the Central Asian natural plague center]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 1993; (3(73)):65–71.

43. Burdelov L.A., Meka-Mechenko V.G., Burdelov D.L. [Some common problems of rodent control and ways to solve them at the present stage]. Sibir-Vostok [Siberia-East]. 2001; 3(39):9–14.

44. Parfenov A.V. [Problems of using anticoagulants during deratization for the purpose of plague prevention]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2014; 2(30):65–70.

45. Meka-Mechenko V.G. [The current situation on the prevention of plague in the Republic of Kazakhstan]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2019; 1(38):23–9.

46. Korzun V.M., Balakhonov S.V., Kosilko S.A., Mikhailov E.P., Mishchenko A.I., Denisov A.V., Rozhdestvensky E.N., Chipanin E.V., Bazarova G.Kh., Yarygina M.B., Abibulaev D.E., Shefer V.V. [Features of the epizootic and epidemic activity of the Gorno-Altai natural focus of plague in 2012–2016]. Epidemiologiya i Vaktsinoprofilaktika [Epidemiology and Vaccinal Prevention]. 2017; 1 (92):36–8. DOI: 10.31631/2073-3046-2017-1-92-36-38.

47. Balakhonov S.V., Schuchinov L.V., Mishchenko A.I., Matrosov A.N., Denisov A.V., Rozhdestvensky E.N., Korzun V.M., Kosilko S.A., Tagyzova S.L., Toporkov V.P., Popov N.V., Scherbakova S.A., Kutyrev V.V. [Organization of preventive, antiepidemic measures in order to reduce the risk of complications of the epidemiological situation on plague in the territory of the Altai Republic]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 2018; 6:85–94. DOI: 10.36233/0372-9311-2018-6-85-94.

48. Aikimbaev A.M., Sagiev Z.A. [The epidemic potential of natural plague foci in Kazakhstan]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2004; 2(10):34–7.

49. Eszhanov A.B., Meka-Mechenko V.G., Sayakova Z.Z., Sadovskaya V.P., Meka-Mechenko T.V., Asylbek A.M. [About the epizootic activity of the Central Asian desert plague focus in the Republic of Kazakhstan in 2017–2018]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2019; 1(38):57–63.

50. Belonog A.A., Zholshorinov A.Zh. [About the state of incidence of particularly dangerous infections among the population and the measures taken to stabilize it in the Republic of Kazakhstan]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2004; 2(10):13–5.

51. Kuznetsov A.N., Syzdykov M.S., Erubaev T.K. [Assessment of the comprehensive plague surveillance system in Kazakhstan]. Karantinnye i Zoonoznye Infektsii v Kazakhstane [Quarantine and Zoonotic Infections in Kazakhstan]. Almaty. 2019; 2(39):3–10.

52. Survillo A.V., Korneev G.A. [Problems of nonspecific prevention in natural foci of plague at the present stage]. Dezinfektsionnoe Delo [Disinfection Affairs]. 1993; 2–3:29–32.

53. Burdelov L.A., Shurubura P.V., Pak I.G. [Deratization and pest control in the system of preventive anti-plague measures at the present stage]. Problemy Osobo Opasnykh Infektsii [Problems of Particularly Dangerous Infections]. 1994; (6(76)):59–67.

54. Karyakin I.V. [The catastrophic consequences of deratisation using bromadiolone in Mongolia in 2001-2003 for Russian bird populations]. Pest-Management [Pest Management]. 2010; 1(73):20–6.

55. Bibikov D.I., Berendyaev S.A., Peysakhis L.A., Schwartz E.A. [Natural Foci of the Marmot Plague in the USSR]. Moscow: “Meditsina”; 1973. 192 p.