Development of Biotechnology for Anthrax Bacteriophages Reproduction, and Comparative Analysis of Their Properties Stability and Diagnostic Value
https://doi.org/10.21055/0370-1069-2014-2-104-107
Abstract
Carried out has been complex comparative analysis of the production and diagnostic properties of such anthrax bacteriophages as Gamma A-26, Fah-RRIVV&M (Russian Research Institute of Veterinary Virology and Microbiology), R/D-Ph-6, BA-9, K RRIEV (Russian Research Institute of Experimental Veterinary), Saratov, and 186. It is revealed that all of the bacteriophages have the properties necessary for using them for preparation manufacturing purposes: they readily proliferate in liquid cultures of avirulent Bacillus anthracis strain - STI, and retain sufficient specific activity if stored at the optimum temperatures or, when exposed to short-term temperature excursions, within a period of two years. Most clearly expressed are the differences in diagnostic properties of the bacteriophages - specific activity and specificity. Put forward are the groups of bacteriophages that are the most relevant for identification or phage-typing of B. anthracis strains.
About the Authors
T. M. Golovinskaya
Stavropol Research Anti-Plague Institute
Russian Federation
Russian Federation
O. I. Tsygankova
Stavropol Research Anti-Plague Institute
Russian Federation
Russian Federation
A. N. Kulichenko
Stavropol Research Anti-Plague Institute
Russian Federation
Russian Federation
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Review
For citations:
Golovinskaya T.M., Tsygankova O.I., Kulichenko A.N. Development of Biotechnology for Anthrax Bacteriophages Reproduction, and Comparative Analysis of Their Properties Stability and Diagnostic Value. Problems of Particularly Dangerous Infections. 2014;(2):104-107. (In Russ.) https://doi.org/10.21055/0370-1069-2014-2-104-107
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