Infection of an Individual with Plague in the Gorno-Altaisk High-Mountain Natural Focus in 2014. Communication 1. Epidemiological and Epizootiological Peculiarities of Plague Manifestations in the Gorno-Altaisk High-Mountain (Sailyugemsky) Natural Plague Focus

For the first time ever since the discovery of the Gorno-Altaisk high-mountain natural focus in 1961, registered has been a case of human plague infection. It occurred in the consequence of the grey marmot cutting that was caught in the territory of one of the persistent epizootic regions of the natural plague focus. The outbreak was localized and eliminated following complex anti-epidemic measures, including medical treatment of the patient; identification, isolation and management of the contact persons, both to the patient and marmot; withdrawal and disposal of marmots’ carcasses, obtained during unauthorized commercial hunting; specific and non-specific prophylaxis of the disease. Also for the first time ever received have been the evidences of concurrent circulation of the strains, subspecies Y. pestis ssp pestis and Y. pestis ssp. altaica in the regions of cohabitation of Pallas’ pika (Ochotona pallasi), Siberian souslik (Citellus undulatus), and grey marmot. Specified is the necessity to reconsider the tactics of epizootiological plague monitoring in enzootic territories where circulation of various Y. pestis subspecies is registered.

Горно-Алтайский высокогорный природный очаг чумы, эпидемический очаг, специфическая и неспецифическая профилактика, основной подвид Yersinia pestis ssp pestis, серый сурок, охотопромысел, Gorno-Altaisk high-mountain natural focus of plague, epidemic focus, specific and non-specific prophylaxis, main subspecies Yersinia pestis ssp pestis, grey marmot, hunting

1. Adýaasuren E., Tserennorov D, Myagmar Zh., Ganhuyag Ts., Otgonbayar D., Bayar Ts., Verzhutsky D.B., Ganbold D., Balakhonov S.V. [Current epidemiological situation in the plague foci of Mongolia]. Dal’nevost. Zh. Infek. Patol. 2014; 25:22–5.

2. Balakhonov S.V., Verzhutsky D.B., Innokent’eva T.I. [Epidemiological assessment of the current state of the natural plague foci in Siberia]. Epidemiol. Vaktsinoprof. 2010; 2:34–7.

3. Balakhonov S.V., Verzhutsky D.B., Korzun V.M., Vershinin E.A., Nemchenko L.S., Chipanin E.V., Shestopalov M.Yu., Innokent’eva T.I., Popkov A.F., Mikhailov E.P., Oorzhak L.M., Vakhrusheva Z.P., Agapov V.A. [Current state of the natural plague foci in Siberia]. Zh. Infek. Patol. 2009; 16(3):16–20.

4. Balakhonov S.V., Afanas’ev M.V., Shestopalov M.Yu., Ostyak A.S., Vityazeva S.A., Korzun V.M., Verzhutsky D.B., Mikhailov E.P., Mishchenko A.I., Denisov A.V., Ivzhenko N.I., Rozhdestvensky E.N., Viskov E.N., Fomina L.A. [The first case of Yersinia pestis subsp. pestis isolation in the territory of Altai mountain natural plague focus. Communication 1. Microbiological characteristics, molecular-genetic and mass-spectrometric identification of the isolate]. Probl. Osobo Opasn. Infek. 2013; 1:60–4.

5. Golubinsky E.P., Zhovty I.F., Lemesheva L.B. [Regarding the Plague in Siberia]. Irkutsk; 1987. 243 p.

6. Eshelkin I.I., Mikhailov E.P. [On the matters of host-specificity of Gorno-Altaisk natural plague focus]. Zh. Infek. Patol. 2009; 16(3):11–2.

7. Kir’yanov G.I. [Dissemination and distribution of rodents and lagomorphs in biotopes of the high-mountain part of the Gorny Altai and adjacent Mongolian regions]. Izvestiya Vost.-Sibir. Otdeleniya Geogr. Obshchestva SSSR. 1971; 68:118–23.

8. Korzun V.M., Chipanin E.V., Innokent’eva T.I., Mikhailov E.P., Denisov A.V. [Dynamics of epizootic activity and abundance of Mongolian pika in the Altai mountain natural plague focus]. Probl. Osobo Opasn. Infek. 2010; 4:13–8.

9. Kutyrev V.V., Popov N.V., Eroshenko G.A., Karavaeva T.B. [Development of the process of natural plague foci typization based on the ecological-genetic analysis of Yersinia pestis]. Zh. Mikrobiol. Epidemiol. Immunobiol. 2013; 5:107–11.

10. Kutyrev V.V., Popova A.Yu., Ezhlova E.B., Demina Yu.V., Pakskina N.D., Sharova I.N., . Mishchenko A.I, Rozhdestvensky E.N., Bazarova G.Kh., Mikhailov E.P., Eroshenko G.A., Krasnov Ya.M., Kukleva L.M., Cherkasov A.V., Oglodin E.G., Kuklev V.E., Odinokov G.N., Shcherbakova S.A., Balakhonov S.V., Afanas’ev M.V., Vityazeva S.A., Shestopalov M.Yu., Klimov V.T. [Infection of an individual with plague in the Gorno-Altaisk highmountain natural focus in 2014. Communication 2. Peculiarities of Laboratory Diagnostics and Molecular-Genetic Characterization of the Isolated Strains]. Probl. Osobo Opasn. Infek. 2014; 4:43–51.

11. Nikitin A.Ya., Maramovich A.S., Kossilko S.A., Innokentieva T.I., Bazanova L.P., Balakhonov S.V., Voronova G.A., Okunev L.P. [Epizootiologic characterization of plague natural foci in Mongolia in connection with designation of protection measures from import and dissemination of the infection into the Russian territory]. Probl. Osobo Opasn. Infek. 2007; 2:28–33.

12. Onishchenko G.G., Kutyrev V.V., editors. [Natural Plague Foci in the Territory of the Caucasus, Caspian-Sea Region, Central Asia and Siberia]. M.: Meditsina; 2004. 192 p.

13. Pavlinov I.Ya., Kruskop S.V., Varshavsky A.A., Borisenko A.V. [Terrestrial Animals of Russia. Reference-Guide]. Moscow, 2002. 488 p.

14. Popkov A.F., Verzhootsky D.B., Korzoon V.M., Innokentieva T.I., Chipanin E.V., Vershinin E.A., Nemchenko L.S., Nikitin A.Ya., Okunev L.P., Bazanova L.P., Tokmakova E.G., Voronova G.A., Logacheov V.I., Mikhailov E.P., Feodorov S.V., Agapov V.A. [Summing-up the results of the populational and ecological investigations into plague natural focality in Siberia carried out in 2001–2005]. Probl. Osobo Opasn. Infek. 2007; 2:33–6.