Sensitizing Properties of Antigen Preparations Obtained from Brucella in S- and L-Forms
https://doi.org/10.21055/0370-1069-2014-4-68-70
Abstract
It is known that S-form Brucella causes allergic transformation in a macroorganism, which is manifested as delayed-type hypersensitivity reaction. This capacity in atypical variants (L-forms) is under-investigated. It is demonstrated that corpuscular antigen in B. abortus 19BA vaccine and thermoextract prepared from B. abortus I-206 in S-form when threefold administered cause marked sensibilization; while corpuscular antigen and thermoextract produced from Brucella in L-form, and thermoextract from Brucella in S-form in case of one time administration do not have such an effect on leucocytes of white mice.
About the Authors
L. M. Mikhailov
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
L. E. Tokareva
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
N. L. Barannikova
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
S. V. Balakhonov
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
References
1. Ashmarin I.P., Vorobiev A.A. [Statistical Methods in Microbiological Investigations]. L.: Medgis; 1962. 180 p.
2. Bronnikov V.S. [Sensibilizing activity of anti-Brucella chemical vaccines]. In: [Actual problems of animal brucellosis and tuberculosis]. Omsk; 2000. P. 164–7.
3. Vershilova P.A. [Brucellosis]. М.: Medicine; 1972. 439 p.
4. Mikhailov L.M., Kalinovsky A.I., Balakhonov S.V. Shestopalov M.Yu., Andreevskaya N.M., Mikhailova V.A., Borisov V.A., Khodus F.I., Gordienko L.N., Oshchepkov V.G. [Persistence of Brucella L-forms in a person with the chronic brucellosis]. Zh. Mikrobiol., Epidemiol. Immunobiol. 2009; 5:114–5.
5. Taran I.F., Tsybin B.P., Krylova A.A., Abolina T.A. [Studying of a role of Brucella L-forms, its revertants and stock cultures]. Zh. Mikrobiol. Epidemiol. Immunobiol. 1981; 6:39–43.
6. Trilenko P.A. [Brucellosis in agricultural animals]. L.: Kolos; 1976. 279 p.
Review
For citations:
Mikhailov L.M., Tokareva L.E., Barannikova N.L., Balakhonov S.V. Sensitizing Properties of Antigen Preparations Obtained from Brucella in S- and L-Forms. Problems of Particularly Dangerous Infections. 2014;(4):68-70. (In Russ.) https://doi.org/10.21055/0370-1069-2014-4-68-70
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