Experimental Technology for O-Antigens Production of Non-Toxigenic Strains of Vibrio cholerae
https://doi.org/10.21055/0370-1069-2013-1-85-87
Abstract
Determined are the key bio-kinetic indexes of submerged cultivation of
Vibrio cholerae non-toxigenic strains, producers of O-antigens. Evaluated is the technology of O-antigen concentration using tangential ultrafiltration technique. The results suggest the principal possibility of using these strains for biologically safe production of chemical cholera vaccines.
Vibrio cholerae non-toxigenic strains, producers of O-antigens. Evaluated is the technology of O-antigen concentration using tangential ultrafiltration technique. The results suggest the principal possibility of using these strains for biologically safe production of chemical cholera vaccines.
About the Authors
S. A. Eremin
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. V. Komissarov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
O. A. Volokh
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
I. A. Shepelev
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
O. V. Gromova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. K. Nikiforov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
Yu. A. Aleshina
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
N. G. Avdeeva
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
N. I. Belyakova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
References
1. Adamov A.K., Naumshina M.S. [Cholera Vibrios] Saratov; 1984. 328 p.
2. Biryukov V.V. [Basic Principles of Industrial Biotechnology]. M.; 2004. 296 p.
3. Gromova O.V., Dzhaparidze M.N., Dyatlov I.A., Eliseev Yu.Yu., Kireev M.N., Naumov A.V. [Oral chemical vaccine against cholera]. Patent RF 2159128.
4. Komissarov A.V., Eremin S.A., Aleshina Yu.A., Vasin Yu.G., Klokova O.D., Belyakova N.I. [Experimental evaluation of application of “cross-flow” ultrafiltration method for O antigen concentrating in cholera chemical bivalent vaccine production]. Probl. Osobo Opasn. Infek. 2006; (108):83–5.
5. Kutyrev V.V., Devdariani Z.L., Sayapina L.V. [Present status of the researches in the sphere of vaccine prophylaxis of particularly dangerous bacterial infections]. Probl. Osobo Opasn. Infek. 2006; (92):18–24.
6. Strelnikova-Aab E.N., Livanova L.F., Goryaev A.A., Cheldyshova N.B., Smirnova N.I. [Vibrio cholerae O1 avirulent strains-producers of protective O1 antigen: obtaining and peculiarities]. Probl. Osobo Opasn. Infek. 2010; (106):39–42.
7. Shchukovskaya T.N., Sayapina L.V., Kutyrev V.V. [Vaccine prophylaxis of cholera: present status]. Epidemiol. Vaktcinoprof. 2009; 2(45):62–7.
8. Cholera, 2000. Weekly Epidemiological Record (WER). 2001; 76(31):233–40.
9. Cholera vaccines: WHO position paper. Weekly Epidemiological Record (WER). 2010; 85(13):117–28.
Review
For citations:
Eremin S.A., Komissarov A.V., Volokh O.A., Shepelev I.A., Gromova O.V., Nikiforov A.K., Aleshina Yu.A., Avdeeva N.G., Belyakova N.I. Experimental Technology for O-Antigens Production of Non-Toxigenic Strains of Vibrio cholerae. Problems of Particularly Dangerous Infections. 2013;(1):85-87. (In Russ.) https://doi.org/10.21055/0370-1069-2013-1-85-87
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