Sorption Properties of Polymeric Enterosorbent and Its Specific Modified Analogue in Simulated Cholera Toxin Solutions in vitro
https://doi.org/10.21055/0370-1069-2014-4-71-74
Abstract
Carried out was comparative study of the sorption properties in polymeric enterosorbent - chitosan, and its specific modified analogue obtained through absorption of anti-toxin immunoglobulins onto the soluble chitosan template. It is determined that soluble chitosan and its specific counterpart express high sorption activity in relation to cholera toxin, thus making lower its initial concentrations. Equilibrium adsorption capacity of the chitosan and its modified variant increase with the raise of initial cholera toxin concentration in the solution. Cholera toxin extraction rate was identified under static conditions. Adsorbate substance recovery rate was registered in the progression. In the course of experiments proved was modified sorbent specific sorption efficiency, occasioned by the presence of the active component in the analogue composition - namely, anti-toxic anticholeraic immunoglobulins. The data obtained are of the importance for further development of specific anticholeraic enterosorbent.
About the Authors
M. V. Ovchinnikova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
M. N. Kireev
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. K. Nikiforov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
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Review
For citations:
Ovchinnikova M.V., Kireev M.N., Nikiforov A.K. Sorption Properties of Polymeric Enterosorbent and Its Specific Modified Analogue in Simulated Cholera Toxin Solutions in vitro. Problems of Particularly Dangerous Infections. 2014;(4):71-74. (In Russ.) https://doi.org/10.21055/0370-1069-2014-4-71-74
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