Toxicity of Various Forms of Yersinia pestis Lipopolysaccharides to D-Galactosamine Sensitized White Mice
https://doi.org/10.21055/0370-1069-2014-4-75-77
Abstract
equals 520÷610 mcg/mouse. Sensitivity of the animals to the stated above LPS forms’ effect when affected by D-GalN is by two orders greater, and as for LPS of the virulent strain is by three orders. Concurrently, differences in toxicity properties in the original (LPS37) and conformationally altered (LPS37-MT) LPS-forms in both of the tested Y. pestis strains drop out of the equation completely.
About the Authors
G. V. Demidova
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
V. P. Zyuzina
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
E. P. Sokolova
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
N. I. Pasyukova
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
I. A. Bespalova
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
T. N. Borodina
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
V. I. Tynyanova
Rostov-on-Don Research Anti-Plague Institute
Russian Federation
Russian Federation
References
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Review
For citations:
Demidova G.V., Zyuzina V.P., Sokolova E.P., Pasyukova N.I., Bespalova I.A., Borodina T.N., Tynyanova V.I. Toxicity of Various Forms of Yersinia pestis Lipopolysaccharides to D-Galactosamine Sensitized White Mice. Problems of Particularly Dangerous Infections. 2014;(4):75-77. (In Russ.) https://doi.org/10.21055/0370-1069-2014-4-75-77
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