Development of a Working Collection of Bacteriophages for the Production of Medical Products for in vitro Diagnostics of Plague and Cholera
K. S. Gumayunova,
M. V. Ovchinnikova,
N. S. Chervyakova,
O. S. Zinina,
E. A. Glazkova,
A. K. Nikiforov https://doi.org/10.21055/0370-1069-2025-4-163-166
Abstract
The Russian Anti-Plague Institute “Microbe” of the Rospotrebnadzor has a working collection of bacterial viruses with varying lytic activity against microorganisms of pathogenicity groups I–III. Many of them are the matrix of medical products for in vitro diagnostics.
The aim of the work was to bring the working collection of bacteriophages in line with the rules for the creation and use of collections of pathogenic microorganisms and viruses set out in Decree of the Government of the Russian Federation No. 1668 dated September 30, 2021 and in accordance with the requirements of Federal Law No. 492-FZ dated December 30, 2020.
Materials and methods. The study involved the usage of a working collection of bacteriophages specific for PBAs of pathogenicity groups I–III. Collection strains of bacteriophages were lyophilized using protective media with a developed formulation.
Results and discussion. Identification and certification of bacteriophages has been carried out. The procedure of author’s deposition of bacteriophages from the working collection into the State Collection of Pathogenic Bacteria of the Institute “Microbe” has been carried out. The working collection of bacteriophages specific for microorganisms of pathogenicity groups I–III has been brought into compliance with the applicable statutory requirements.
About the Authors
K. S. Gumayunova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
Kristina S. Gumayunova,
46, Universitetskaya St., Saratov, 410005
M. V. Ovchinnikova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
46, Universitetskaya St., Saratov, 410005
N. S. Chervyakova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
46, Universitetskaya St., Saratov, 410005
O. S. Zinina
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
46, Universitetskaya St., Saratov, 410005
E. A. Glazkova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
46, Universitetskaya St., Saratov, 410005
A. K. Nikiforov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
46, Universitetskaya St., Saratov, 410005
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Review
For citations:
Gumayunova K.S., Ovchinnikova M.V., Chervyakova N.S., Zinina O.S., Glazkova E.A., Nikiforov A.K. Development of a Working Collection of Bacteriophages for the Production of Medical Products for in vitro Diagnostics of Plague and Cholera. Problems of Particularly Dangerous Infections. 2025;(4):163-166. (In Russ.) https://doi.org/10.21055/0370-1069-2025-4-163-166
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