Diagnostics of Severe Fever with Thrombocytopenia Syndrome – Disease, Caused by Novel Phlebovirus
https://doi.org/10.21055/0370-1069-2016-3-21-26
Abstract
In 2009, a novel virus, named severe fever with thrombocytopenia syndrome (SFTS) virus, was isolated from a patient in China. The illness caused by this novel virus is characterized by a sudden onset of fever and respiratory or gastrointestinal disorders, followed by progressive thrombocytopenia and leucocytopenia, the case-fatality rate amounting to 6–30 %. Genomic sequencing of the isolated agent indicated that the SFTS virus constituted a new (third) group of Phlebovirus genus, Bunyaviridae family. Presently, different means for specific diagnostics of SFTS (real-time reverse transcription polymerase chain reaction, indirect fluorescent antibodies method, enzyme-linked immune-sorbent assay) are developed. Constructing of diagnostic kits, basic characteristics of methods for determination of causative agent of infection or specific antibodies against it are considered in this review.
Keywords
severe fever with thrombocytopenia syndrome,
severe fever with thrombocytopenia syndrome virus, phlebovirus, genomic RNA, primer, reverse transcription-polymerase chain reaction, fluorescent antibodies method,
enzyme linked immunosorbent assay,
neutralization testing,
sensitivity,
specificity
About the Authors
T. E. Sizikova
The 48th Central Research Institute of the Ministry of Defense of the Russian Federation
Russian Federation
Russian Federation
V. N. Lebedev
The 48th Central Research Institute of the Ministry of Defense of the Russian Federation
Russian Federation
Russian Federation
N. V. Boyarskaya
The 48th Central Research Institute of the Ministry of Defense of the Russian Federation
Russian Federation
Russian Federation
S. V. Borisevich
The 48th Central Research Institute of the Ministry of Defense of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Sizikova T.E., Lebedev V.N., Boyarskaya N.V., Borisevich S.V. Diagnostics of Severe Fever with Thrombocytopenia Syndrome – Disease, Caused by Novel Phlebovirus. Problems of Particularly Dangerous Infections. 2016;(3):21-26. (In Russ.) https://doi.org/10.21055/0370-1069-2016-3-21-26
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