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Проблемы особо опасных инфекций

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СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ПАТОГЕНЕЗА ЧУМЫ

https://doi.org/10.21055/0370-1069-2017-3-33-40

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Аннотация

В обзоре проведен краткий анализ опубликованных за последние десять лет результатов исследований, посвященных изучению молекулярных механизмов действия известных на сегодняшний день факторов вирулентности возбудителя чумы Yersinia pestis. Проанализированы разные компоненты Y. pestis, синтезирующиеся бактериями на четырех этапах инфекционного процесса при бубонной форме чумы: в коже, лимфоузлах, паренхиматозных органах и крови. Описаны факторы и механизмы, которые лежат в основе защиты микробов от бактерицидного действия гуморальных и клеточных факторов врожденного иммунитета хозяина, которые по-разному воздействуют на организм животных, стимулируя проили противовоспалительную реакцию хозяина на инфекцию, и способствуют смене жизненного цикла бактерий внутри хозяина, обеспечивая переход от внутриклеточного размножения в фагоцитах на первых этапах инфекции к внеклеточному размножению в лимфоузле, селезенке, печени и крови на последующих. В обзоре рассматриваются только те факторы Y. pestis, взаимодействие которых с молекулами и клетками хозяина на разных этапах инфекционного процесса экспериментально доказано.

Об авторе

О. Н. Подладчикова
ФКУЗ «Ростовский-на-Дону научно-исследовательский противочумный институт»
Россия
344002, Ростов-на-Дону, ул. М.Горького, 117/40


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Для цитирования:


Подладчикова О.Н. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ПАТОГЕНЕЗА ЧУМЫ. Проблемы особо опасных инфекций. 2017;(3):33-40. https://doi.org/10.21055/0370-1069-2017-3-33-40

For citation:


Podladchikova O.N. MODERN VIEWS ON MOLECULAR MECHANISMS OF PLAGUE PATHOGENESIS. Problems of Particularly Dangerous Infections. 2017;(3):33-40. (In Russ.) https://doi.org/10.21055/0370-1069-2017-3-33-40

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