Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens
https://doi.org/10.21055/0370-1069-2010-1(103)-56-59
Abstract
Evaluated was the ability of plague microbe antigens F1 and V to activate specifically in the in vitro system subpopulations of T-lymphocytes of BALB/c mice immunized against plague. The level of CD69 expression at the lymphocytes surface was proposed to be evaluated as the marker of lymphocytes activation. Expression of CD69 early marker of activation in subpopulations of T-helpers and cytotoxic lymphocytes, reciprocated by the in vitro stimulation with Y. pestis F1, correlated with the intensity of the anti-plague postvaccinal immunity induced by immunization with F1 or F1and V antigens mixtures.
About the Authors
V. V. Firstova
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
I. V. Bakhteeva
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
G. M. Titareva
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
E. V. Zyrina
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
S. A. Ivanov
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
N. V. Kisseleva
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
P. Kh. Kopylov
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
A. P. Anisimov
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
I. A. Dyatlov
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
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Review
For citations:
Firstova V.V., Bakhteeva I.V., Titareva G.M., Zyrina E.V., Ivanov S.A., Kisseleva N.V., Kopylov P.Kh., Anisimov A.P., Dyatlov I.A. Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens. Problems of Particularly Dangerous Infections. 2010;(1(103)):56-59. (In Russ.) https://doi.org/10.21055/0370-1069-2010-1(103)-56-59
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