Historical and Modern Views on the Problem of Specific Plague Prophylaxis
https://doi.org/10.21055/0370-1069-2013-3-63-69
Abstract
Objective of this review is to analyze diachronically paradigm shift as regards problems of specific plague prophylaxis and appreciate contribution of the present-day scientific discoveries in the sphere of plague agent investigations and peculiarities of its interaction with host organism to the solution of topical issues of vaccine development that will be safe and tangibly effective against this particularly dangerous disease. Outlined is the historical background of the conceptual evolution concerning specific plague prophylaxis and events that are landmarked with eminent scientific discoveries by A.Yersin, French researcher and microbiologist. Given are the data on the current state of plague immune-prophylaxis both in Russia and around the world. Through the prism of the latest researches that assume application of advanced technological resource of medical sciences (molecular biology, biotechnology, bioinformatics, molecular immunology) put forward is the prospective of search and construction of safe and effective anti-plague next generation vaccines.
About the Authors
S. A. Bugorkova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
Z. L. Devdariani
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
T. N. Shchukovskaya
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
V. V. Kutyrev
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
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Review
For citations:
Bugorkova S.A., Devdariani Z.L., Shchukovskaya T.N., Kutyrev V.V. Historical and Modern Views on the Problem of Specific Plague Prophylaxis. Problems of Particularly Dangerous Infections. 2013;(3):63-69. (In Russ.) https://doi.org/10.21055/0370-1069-2013-3-63-69
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